US4379038A
Expired / Lapsed
US
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Process for preparing a physiologically active substance controlled release composite composition
Assignee: Japan Atomic Energy Agency
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Filing: 1980-09-19
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Granted: 1983-04-05
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Expires: 2000-09-19
Abstract
Abstract A physiologically active substance controlled release composite composition is prepared by a process which comprises the steps of: adding a physiologically active substance to a physiologically active substance-containing adsorbent previously prepared by adsorbing the same or a different physiologically active substance onto an inorganic adsorbent, and dispersing and mixing; dispersing the resulting mixture in a polymerizable vinyl monomer containing 0 to 50% of synthetic high molecular weight subtance which is polymerizable at a temperature of below -20° C.; and, after holding the desired shape, irradiating the resulting dispersion with an ionizing radiation at a temperature of -20° to -100° C. to polymerize.
Inventors
- 👤 Isao Kaetsu
- 👤 Masaru Yoshida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/14; A61K9/141; A61K9/143; A61K9/20; A61K9/2004; A61K9/2022; A61K9/2027; C; C08; C08F; C08F2/00; C08F2/44; C08F2/46
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
114 words
A process for preparing a physiologically active substance controlled release composite composition which comprises the steps of: using a physiologically active substance-containing adsorbent prepared by adsorbing a first physiologically active substance onto an inorganic adsorbent; dispersing and mixing a second physiologically active substance, which is different from said first physiologically active substance, onto said physiologically active substance containing adsorbent; dispersing the resulting mixture in a polymerizable vinyl monomer containing 0-50% of a synthetic high molecular weight substance which is polymerizable at a temperature of below -20° C.; and after holding the desired shape, irradiating the resulting dispersion with an ionizing radiation at a temperature within the range of -20° to -100° C. to polymerize.
Claim 2
Dependent Claim
114 words
A process for preparing a physiologically active substance controlled release composite composition which comprises the steps of: using a physiologically active substance-containing adsorbent prepared by adsorbing a first physiologically active substance onto an inorganic adsorbent; dispersing and mixing a second physiologically active substance, which is different from said first physiologically active substance, onto said physiologically active substance containing adsorbent; dispersing the resulting mixture in a polymerizable vinyl monomer containing 0-50% of a synthetic high molecular weight substance which is polymerizable at a temperature of below -20° C.; and after holding the desired shape, irradiating the resulting dispersion with an ionizing radiation at a temperature within the range of -20° to -100° C. to polymerize.
Claim 3
Dependent Claim
36 words
The process as set forth in claim 7 wherein said physiologically active substance-containing adsorbent is a mixture of two or more different kinds of inorganic adsorbent each of which has adsorbed a different physiologically active substance.
Claim 4
Dependent Claim
80 words
The process as set forth in claim 1 or 2 wherein 0.1 to 50 parts, by weight, of said physiologically active substance are added to said physiologically active substance-containing adsorbent previously prepared by adsorbing 0.1 to 50 parts, by weight, of the same or different physiologically active substance onto 0.1 to 10 parts, by weight, of inorganic adsorbent, and dispersed and mixed, and the resulting mixture is dispersed in 1.0 to 80 parts, by weight, of said polymerizable vinyl monomer.
Claim 5
Dependent Claim
122 words
A process for preparing a physiologically active substance controlled release composite composition which comprises the steps of: dispersing and mixing a polymerizable vinyl monomer containing 0 to 50% of a synthetic high molecular weight substance and a physiologically active substance; irradiating the resulting mixture with an ionizing radiation to polymerize said polymerizable vinyl monomer; grinding the resulting polymer to 10 to 2000 μm in size; adding the same or a different physiologically active substance and a polymerizable vinyl monomer containing 0 to 50% of a synthetic high molecular weight substance to the resulting ground product, and dispersing and mixing; and after holding the desired shape, irradiating the mixture with an ionizing radiation at a temperature of -20° to -100° C. to polymerize.
Claim 6
Dependent Claim
122 words
A process for preparing a physiologically active substance controlled release composite composition which comprises the steps of: dispersing and mixing a polymerizable vinyl monomer containing 0 to 50% of a synthetic high molecular weight substance and a physiologically active substance; irradiating the resulting mixture with an ionizing radiation to polymerize said polymerizable vinyl monomer; grinding the resulting polymer to 10 to 2000 μm in size; adding the same or a different physiologically active substance and a polymerizable vinyl monomer containing 0 to 50% of a synthetic high molecular weight substance to the resulting ground product, and dispersing and mixing; and after holding the desired shape, irradiating the mixture with an ionizing radiation at a temperature of -20° to -100° C. to polymerize.
Claim 7
Dependent Claim
32 words
The process as set forth in claim 4 wherein said ground product is a mixture of two or more kinds of ground product each of which contains a different physiologically active substance.
Claim 8
Dependent Claim
101 words
The process as set forth in claim 4 or 5 wherein 0.1 to 10 parts, by weight, of said polymerizable vinyl monomer and 0.1 to 50 parts, by weight, of said physiologically active substance are dispersed and mixed, and are irradiated with an ionizing radiation to polymerize said polymerizable monomer, the resulting polymer is ground to 10 to 2000 μm in size, and 0.1 to 50 parts, by weight, of the same or different physiologically active substance and 5 to 30 parts, by weight, of said polymerizable vinyl monomer are added to 10 parts, by weight, of the resulting ground product.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-04-04 | 1986-10-04 | 1987-04-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-04-04 | 1990-10-04 | 1991-04-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-04-04 | 1994-10-04 | 1995-04-05 | $7700.00 | Window Closed / Lapsed |