US4717713A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Controlled release liquid pharmaceutical
Assignee: Research Corp
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Filing: 1983-10-31
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Granted: 1988-01-05
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Expires: 2003-10-31
Abstract
Abstract A controlled release pharmaceutical composition including a solution or suspension vehicle and a pharmaceutically active agent. The composition is administered to the body in a normally liquid formulation and thereafter forms a semi-solid gel-like matrix in the environment of the stomach thereby effecting controlled release of the pharmaceutically active agent.
Inventors
- 👤 Joel L. Zatz
- 👤 David W. Woodford
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 06:31
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0053; A61K9/0065; A61K47/00; A61K47/30; A61K47/36; A61K47/38; A61K47/42
Claims Analysis
Total Claims: 27
Claim 1
Independent Claim
81 words
A method for the controlled release administration of a pharmaceutically active agent comprising orally introducing said agent to the body in a normally liquid formulation containing a solution or suspension vehicle selected from the group consisting essentially of xanthan gum, sodium alginate, gelatin, carrageenan, methylcellulose and mixtures thereof in an amount from about 0.3 to about 5.0 percent by weight which forms a semi-solid gel-like matrix in the environment of the stomach thereby controlling the release of said pharmaceutically active agent.
Claim 2
Independent Claim
81 words
A method for the controlled release administration of a pharmaceutically active agent comprising orally introducing said agent to the body in a normally liquid formulation containing a solution or suspension vehicle selected from the group consisting essentially of xanthan gum, sodium alginate, gelatin, carrageenan, methylcellulose and mixtures thereof in an amount from about 0.3 to about 5.0 percent by weight which forms a semi-solid gel-like matrix in the environment of the stomach thereby controlling the release of said pharmaceutically active agent.
Claim 3
Dependent Claim
20 words
The method of claim 1 wherein said vehicle comprises from about 0.3 to about 3 percent xanthan gum by weight.
Claim 4
Dependent Claim
20 words
The method of claim 1 wherein said vehicle comprises from about 0.5 to about 3 percent sodium alginate by weight.
Claim 5
Dependent Claim
23 words
The method of claim 1 wherein said vehicle comprises from about 0.3 to about 1.5 percent by weight of each gelatin and carrageenan.
Claim 6
Dependent Claim
19 words
The method of claim 1 wherein said vehicle comprises from about 1 to about 3 weight percent of methylcellulose.
Claim 7
Dependent Claim
21 words
The method of claim 1 wherein said vehicle comprises about 2 percent methylcellulose and about 5 percent sodium chloride by weight.
Claim 8
Dependent Claim
32 words
The method of claim 1 wherein the formulation further comprises additional excipients selected from locust bean gum, salts, sugars, Na 3 PO 4 , CaCO 3 and Ca 2 HPO 4 .
Claim 9
Dependent Claim
12 words
The method of claim 1 wherein said pharmaceutically active agent comprises theophylline.
Claim 10
Dependent Claim
83 words
In a method for controlled release administration of a pharmaceutically active agent, the improvement comprising orally administering said agent to the body in a normally liquid formulation containing a solution or suspension vehicle selected from the group consisting essentially of xanthan gum, sodium alginate, gelatin, carrageenan, methylcellulose and mixtures thereof in an amount from about 0.3 to about 5.0 percent by weight which forms a semi-solid gel-like matrix in the environment of the stomach thereby controlling the release of said pharmaceutically active agent.
Claim 11
Dependent Claim
83 words
In a method for controlled release administration of a pharmaceutically active agent, the improvement comprising orally administering said agent to the body in a normally liquid formulation containing a solution or suspension vehicle selected from the group consisting essentially of xanthan gum, sodium alginate, gelatin, carrageenan, methylcellulose and mixtures thereof in an amount from about 0.3 to about 5.0 percent by weight which forms a semi-solid gel-like matrix in the environment of the stomach thereby controlling the release of said pharmaceutically active agent.
Claim 12
Dependent Claim
20 words
The method of claim 9 wherein said vehicle comprises from about 0.3 to about 3 percent xanthan gum by weight.
Claim 13
Dependent Claim
20 words
The method of claim 9 wherein said vehicle comprises from about 0.5 to about 3 percent sodium alginate by weight.
Claim 14
Dependent Claim
23 words
The method of claim 9 wherein said vehicle comprises from about 0.3 to about 1.5 percent by weight of each gelatin and carrageenan.
Claim 15
Dependent Claim
19 words
The method of claim 9 wherein said vehicle comprises from about 1 to about 3 weight percent of methylcellulose.
Claim 16
Dependent Claim
21 words
The method of claim 9 wherein said vehicle comprises about 2 percent methylcellulose and about 5 percent sodium chloride by weight.
Claim 17
Dependent Claim
32 words
The method of claim 9 wherein the formulation further comprises additional excipients selected from locust bean gum, salts, sugars, Na 3 PO 4 , CaCO 3 and Ca 2 HPO 4 .
Claim 18
Dependent Claim
12 words
The method of claim 9 wherein said pharmaceutically active agent comprises theophylline.
Claim 19
Dependent Claim
72 words
A controlled release pharmaceutical composition comprising a normally liquid formulation containing a solution or suspension vehicle selected from the group consisting essentially of xanthan gum, sodium alginate, gelatin, carrageenan, methylcellulose and mixtures thereof in an amount from about 0.3 to about 5.0 percent by weight and a pharmaceutically active agent, said vehicle forming a semi-solid gel-like matrix in the environment of the stomach thereby controlling the release of said pharmaceutically active agent.
Claim 20
Dependent Claim
72 words
A controlled release pharmaceutical composition comprising a normally liquid formulation containing a solution or suspension vehicle selected from the group consisting essentially of xanthan gum, sodium alginate, gelatin, carrageenan, methylcellulose and mixtures thereof in an amount from about 0.3 to about 5.0 percent by weight and a pharmaceutically active agent, said vehicle forming a semi-solid gel-like matrix in the environment of the stomach thereby controlling the release of said pharmaceutically active agent.
Claim 21
Dependent Claim
21 words
The composition of claim 17 wherein the said vehicle comprises from about 0.3 to about 3 percent xanthan gum by weight.
Claim 22
Dependent Claim
20 words
The composition of claim 17 wherein said vehicle comprises from about 0.5 to about 3 percent sodium alginate by weight.
Claim 23
Dependent Claim
23 words
The composition of claim 17 wherein said vehicle comprises from about 0.3 to about 1.5 percent by weight of each gelatin and carrageenan.
Claim 24
Dependent Claim
19 words
The composition of claim 17 wherein said vehicle comprises from about 1 to about 3 weight percent of methylcellulose.
Claim 25
Dependent Claim
21 words
The composition of claim 17 wherein said vehicle comprises about 2 percent methylcellulose and about 5 percent sodium chloride by weight.
Claim 26
Dependent Claim
32 words
The composition of claim 17 wherein the formulation further comprises additional excipients selected from locust bean gum, salts, sugars, Na 3 PO 4 , CaCO 3 and Ca 2 HPO 4 .
Claim 27
Dependent Claim
12 words
The composition of claim 17 wherein said pharmaceutically active agent comprises theophylline.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1991-01-04 | 1991-07-06 | 1992-01-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1995-01-04 | 1995-07-06 | 1996-01-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1999-01-04 | 1999-07-06 | 2000-01-05 | $7700.00 | Window Closed / Lapsed |