Oral sustained-action capsule formulations - of drug and excipient which swells in contact with digestive juices

Abstract

Abstract Oral compsns. with sustained activity comprising the active drug and an excipient which swells in contact with digestive juices, this being =45% w/w of the compsn., contained in hard gelatin capsules. The compsns. may contain drugs such as aspirin, nitrofurantoin and naftidrofuryl. Swelling agents include guar gum, tragacanth and hydroxypropylmethylcellulose. A preferred agent with aspirin is 40-45% w/w of hydroxy-propylmethylcellulose; for naftidrofuryl 20-25% w/w of swelling agent. Conventional additives such as lubricants and fillers may be used, e.g. magnesium stearate, lactose kaolin, colloidal silica.

Inventors

• 👤 Jean-Claude Lechevin
• 👤 Jean-Noel Treilles
• 👤 Francoise Merle
• 👤 Maryse Belleville

Bibliographic Details