Medicament adsorbates with surfactant and their preparation

Claim 2

A medicament adsorbate which comprises: a complex magnesium aluminum silicate having sorbed therein a solution of medicament drug and a surfactant.

Claim 3

The medicament absorbate of claim 1 wherein the medicament drug is present in an amount of about 1 to about 35% by weight and the complex magnesium aluminum silicate is present in an amount of about 65% to about 99% by weight, all percents herein are by weight percent of the medicament absorbate.

Claim 4

The medicament absorbate of claim 1 wherein the surfactant is present in an amount of about 0.05% to about 4% by weight of the medicament absorbate.

Claim 5

the medicament absorbate of claim 1 further comprising a solvent content up to about 20% by weight of the medicament absorbate.

Claim 6

The medicament absorbate of claim 1 further comprising a solvent content from about 2% to about 15% by weight of the medicament absorbate.

Claim 7

The medicament absorbate of claim 1 wherein the surfactant is selected from the group consisting of sodium lauryl sulfate, Pluronics and mixtures thereof.

Claim 8

The medicament absorbate of claim 1 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 55 to 70 3.2 to 35 Magnesium oxide 2.9 to 25 0.17 to 12.5 Aluminum oxide 2.0 to 17 1 Ferric oxide 0.4 to 1.8 Calcium oxide 1.1 to 2.4 Sodium oxide 1.0 to 3.8 Potassium oxide 0.2 to 1.9 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 9

The medicament adsorbate of claim 1 wherein the complex magnesium aluminum silicate has the following typical chemical analysis: ______________________________________ Ratio to Percent by Weight Aluminum Oxide ______________________________________ Silicon dioxide 56 to 59 14.0 to 35 Magnesium oxide 21 to 24 5.2 to 12.0 Aluminum oxide 2.0 to 4.0 1 Ferric oxide 0.4 to 0.6 Calcium oxide 1.1 to 1.5 Sodium oxide 2.5 to 3.5 Potassium oxide 0.5 to 1.0 Ignition Loss 5.5 to 12.6 ______________________________________

Claim 10

A process for preparing a medicament adsorbate which comprises: admixing a complex magnesium aluminum silicate with a medicament drug, a surfactant and a sufficient amount of solvent to dissolve the medicament drug and surfactant to form a mass containing said medicament drug and surfactant in an adsorbed condition, and recovering the medicament adsorabte.

Claim 11

A process for preparing a medicament adsorbate which comprises: admixing a complex magnesium aluminum silicate with a medicament drug, a surfactant and a sufficient amount of solvent to dissolve the medicament drug and surfactant to form a mass containing said medicament drug and surfactant in an adsorbed condition, and recovering the medicament adsorabte.

Claim 12

The process of claim 9 wherein the solvent is present in amounts from about 10% to about 60% by weight of the medicament adsorbate.

Claim 13

The process of claim 9 wherein the medicament drug is present in an amount of about 1% to about 35% by weight and the complex magnesium aluminum silicate is present in an amount of about 65% to about 99% by weight, all percents herein are by weight percent of the medicament adsorbate.

Claim 14

The process of claim 9 wherein the surfactant is present in an amount of about 0.05% to about 4% by weight of the medicament adsorbate.

Claim 15

The process of claim 9 further comprising drying the mass to a final solvent content up to about 20% by weight of the medicament adsorbate.

Claim 16

The process of claim 9 wherein the solvent is present in an amount from about 1 to about 20 times by weight of the complex magnesium aluminum silicate.

Claim 17

A medicated composition which comprises a pharmaceutically acceptable carrier and from about 1% to about 60% by weight of the final composition of a medicament adsorbate containing a complex magnesium aluminum silicate having sorbed therein a medicament drug and a surfactant.

Claim 18

A medicated composition which comprises a pharmaceutically acceptable carrier and from about 1% to about 60% by weight of the final composition of a medicament adsorbate containing a complex magnesium aluminum silicate having sorbed therein a medicament drug and a surfactant.

Claim 19

The medicated composition of claim 15 wherein the pharmaceutically acceptable carrier is selected from a group consisting of a lozenge, a tablet, suspension, toffee, nougat, chewy candy and chewing gum.

Claim 20

A medicated confectionery product comprising: a bulking agent of up to about 99%; a therapeutically effective amount of a medicament adsorbate comprising; a complex magnesium aluminum silicate having sorbed therein a medicament drug and a surfactant, said medicament adsorbate being admixed in the confectionery product. all percents herein are by weight of the medicated confectionery product.

Claim 21

A medicated confectionery product comprising: a bulking agent of up to about 99%; a therapeutically effective amount of a medicament adsorbate comprising; a complex magnesium aluminum silicate having sorbed therein a medicament drug and a surfactant, said medicament adsorbate being admixed in the confectionery product. all percents herein are by weight of the medicated confectionery product.

Claim 22

A medicated chewing gum product containing a therapeutically effective amount of medicament drug which comprises: a chewing gum composition in an amount up to about 99% comprising; a gum base, and a sweetener; a therapeutically effective amount of a medicament adsorbate comprising a complex magnesium aluminum silicate having sorbed thereon a dispersion of a medicament drug and a surfactant, said medicament adsorbate being admixed in the chewing gum composition, all percents herein are by weight of the medicated chewing gum product.

Claim 23

A medicated chewing gum product containing a therapeutically effective amount of medicament drug which comprises: a chewing gum composition in an amount up to about 99% comprising; a gum base, and a sweetener; a therapeutically effective amount of a medicament adsorbate comprising a complex magnesium aluminum silicate having sorbed thereon a dispersion of a medicament drug and a surfactant, said medicament adsorbate being admixed in the chewing gum composition, all percents herein are by weight of the medicated chewing gum product.