US4710191A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Therapeutic device for the administration of medicaments
Assignee: Mylan Technologies Inc
•
Filing: 1985-12-16
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Granted: 1987-12-01
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Expires: 2005-12-16
Abstract
Abstract A therapeutic device in the nature of a transdermal administration system is disclosed for administration of a medicament to the skin or mucosa of a host. The device is provided with a reservoir for containment of the medicament which is isolated by means of a peelable heat sealed area with respect to an adhesive layer provided for adhering the device to the host. In this manner, contamination and deterioration of the adhesive layer, contamination of the active agent, and trapping of the active agent in the adhesive layer are all avoided.
Inventors
- 👤 Alfred Kwiatek
- 👤 Jack W. Schwartz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7084
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
171 words
A device for the administration of an active agent to the skin or mucosa of a host comprising a reservoir containing said active agent, said reservoir including an inner surface and an outer surface, a release layer formed on said inner surface of said reservoir, and active agent impermeable backing layer formed on said outer surface of said reservoir, said backing layer overlying said release layer and sealed thereto about a circumferential sealed area so as to enclose said reservoir, said backing layer and said release layer extending peripherally beyond said sealed area about the entire periphery thereof so as to create an extended peripheral area, adhesive means disposed between said backing layer and said release layer in said extended peripheral area and thereby separated from said reservoir by said sealed area, said adhesive means addapted to adhere said device to the skin or mucosa of said host upon removal of said release layer, whereby said active agent is released from said reservoir to provide a dose of said active agent.
Claim 2
Independent Claim
171 words
A device for the administration of an active agent to the skin or mucosa of a host comprising a reservoir containing said active agent, said reservoir including an inner surface and an outer surface, a release layer formed on said inner surface of said reservoir, and active agent impermeable backing layer formed on said outer surface of said reservoir, said backing layer overlying said release layer and sealed thereto about a circumferential sealed area so as to enclose said reservoir, said backing layer and said release layer extending peripherally beyond said sealed area about the entire periphery thereof so as to create an extended peripheral area, adhesive means disposed between said backing layer and said release layer in said extended peripheral area and thereby separated from said reservoir by said sealed area, said adhesive means addapted to adhere said device to the skin or mucosa of said host upon removal of said release layer, whereby said active agent is released from said reservoir to provide a dose of said active agent.
Claim 3
Dependent Claim
24 words
The device of claim 1 wherein said backing layer includes a heat sealable layer in contact with said release layer within said sealed area.
Claim 4
Dependent Claim
38 words
The device of claim 1 wherein said backing layer comprises a coextruded layer of a primary backing layer impermeable to said active agent and a heat sealable layer in contact with said release layer within said sealed area.
Claim 5
Dependent Claim
55 words
The device of claim 1 including a release coating provided on the inner surface of said release layer facing said reservoir and extending at least within said sealed area, whereby said release layer may be removed from said device for adhering said device to the skin or mucosa of said host by said adhesive means.
Claim 6
Dependent Claim
27 words
The device of claim 4 wherein said release coating further extends within said extended peripheral area to facilitate removal of said release layer from said adhesive means.
Claim 7
Dependent Claim
43 words
The device of claim 1 wherein said backing layer includes a primary backing layer impermeable to said active agent and extending at least to said sealed area and a secondary outer backing layer overlying said primary backing layer and said extended peripheral area.
Claim 8
Dependent Claim
39 words
The device of claim 6 wherein said secondary outer backing layer includes an inner surface and an outer surface, and said adhesive means comprising an adhesive layer extending over the entire inner surface of said secondary outer backing layer.
Claim 9
Dependent Claim
18 words
The device of claim 7 wherein said adhesive layer comprises an adhesive substantially impermeable to said active agent.
Claim 10
Dependent Claim
22 words
The device of claim 1 wherein said adhesive means comprises an adhesive layer comprising an adhesive substantially impermeable to said active agent.
Claim 11
Dependent Claim
45 words
The device of claim 1 further including an active agent permeable membrane disposed between said inner surface of said reservoir and said release layer, and extending at least to said sealed area so as to be sealed between said backing layer and said release layer.
Claim 12
Dependent Claim
35 words
The device of claim 1 or 10 including an annular gap in said extended peripheral area between said sealed area and said adhesive means so as to further separate said adhesive means from said reservoir.
Claim 13
Dependent Claim
17 words
The device of claim 1 wherein said reservoir contains a sponge for retaining said active agent therein.
Claim 14
Dependent Claim
27 words
The device of claim 1 wherein said sealed area comprises a peelable heat seal, whereby the removal of said release layer from said device can be facilitated.
Claim 15
Dependent Claim
28 words
The device of claim 1 wherein said release layer extends outwardly beyond said backing layer so as to act as a tab for removal of said release layer.
Claim 16
Dependent Claim
41 words
The device of claim 1 wherein said backing layer comprises a material selected from the group consisting of cellophane, cellulose acetate, ethyl cellulose, plasticized vinyl acetate-vinyl chloride copolymers, ethylene-vinyl acetate copolymer, polyethylene terephthalate, nylon, polyethylene, polypropylene, polyvinylidene chloride and aluminum foil.
Claim 17
Dependent Claim
13 words
The device of claim 3 wherein said coextruded layer comprises a metalized film.
References Cited (Backward Citations)
US2235436A
Cited
US2561071A
Cited
US3797494A
Cited
US3814095A
Cited
US3972995A
Cited
US4052505A
Cited
US4117841A
Cited
US4176664A
Cited
EP0008545A2
Cited
US4268497A
Cited
US4402696A
Cited
US4297995A
Cited
US4341208A
Cited
US4379454A
Cited
US4460372A
Cited
US4486193A
Cited
US4460368A
Cited
US4460370A
Cited
US4468194A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-30 | 1991-06-01 | 1991-12-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-30 | 1995-06-01 | 1995-12-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-30 | 1999-06-01 | 1999-12-01 | $7700.00 | Window Closed / Lapsed |