US4705782A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Indene and naphthalene derivatives
Assignee: Organon NV
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Filing: 1986-03-26
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Granted: 1987-11-10
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Expires: 2006-03-26
Abstract
Abstract The invention relates to compounds of the general formula I ##STR1## wherein R 1 represents one up to and including four, the same or different substituents selected from alkyl(1-6 C), alkoxy(1-6 C), hydroxy, halogen, NO 2 , CF 3 or the group --NR 5 R 6 , whereby two substituents taken together may also represent a methylene-dioxy group, X represents a member selected from ##STR2## --CH 2 --CH 2 -- and --CH═CH--, n has the value 0, 1 or 2, R 3 represents one of the moieties: ##STR3## and R 2 , R 4 , R 5 and R 6 represent hydrogen or alkyl(1-6 C), and pharmaceutically acceptable salts thereof, suitable in the treatment of heartfailure.
Inventors
- 👤 Robert T. Logan
- 👤 James Redpath
- 👤 Robert G. Roy
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 16:33
CPC Classifications
C; C07; C07C; C07C15/00; C07C15/20; C07C15/24; C07C259/00; C07C259/12; C07C259/18; A; A61; A61P; A61P9/00; A61P9/04; C07C239/00; C07C239/08; C07C281/00; C07C281/16; C07C281/18
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
110 words
Indene and naphthalene derivatives of the formula I ##STR15## wherein R 1 represents one up to and including four, the same or different substituents selected from alkyl (1-6 C), alkoxy (1-6 C), hydroxy, halogen, NO 2 , CF 3 or the group --NR 5 R 6 , whereby two substituents taken together may also represent a methylene dioxy group, X represents the group --CH-- or --CH 2 --CH 2 --, n has the value 0, 1 or 2, R 3 represents one of the moieties: ##STR16## and R 2 , R 4 , R 5 , and R 6 represent hydrogen or alkyl (1-6 C), and pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
110 words
Indene and naphthalene derivatives of the formula I ##STR15## wherein R 1 represents one up to and including four, the same or different substituents selected from alkyl (1-6 C), alkoxy (1-6 C), hydroxy, halogen, NO 2 , CF 3 or the group --NR 5 R 6 , whereby two substituents taken together may also represent a methylene dioxy group, X represents the group --CH-- or --CH 2 --CH 2 --, n has the value 0, 1 or 2, R 3 represents one of the moieties: ##STR16## and R 2 , R 4 , R 5 , and R 6 represent hydrogen or alkyl (1-6 C), and pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
14 words
Compound according to claim 1, in which X represents --CH 2 --CH 2 --.
Claim 4
Dependent Claim
31 words
Compound according to claim 1, in which R 1 represents at least two oxygen bearing substituents selected from alkoxy and hydroxy or in which R 1 represents a methylene dioxy group.
Claim 5
Dependent Claim
17 words
Compound according to claim 3, in which R 1 represents a dimethoxy or a hydroxy-methoxy substitution pattern.
Claim 6
Dependent Claim
25 words
Pharmaceutical preparation having a positive inotropic effect comprising an effective amount of a compound according to claim 1 in admixture with a pharmaceutically acceptable carrier.
Claim 7
Dependent Claim
12 words
The compound according to claim 1: 1,2-dihydro-N-hydroxy-6,7-dimethoxy-naphthalene-3-carboximidamide and pharmaceutically acceptable salts thereof.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-09 | 1991-05-11 | 1991-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-09 | 1995-05-11 | 1995-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-09 | 1999-05-11 | 1999-11-10 | $7700.00 | Window Closed / Lapsed |