US4272547A
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Benzoyl indane carboxamides as antiphlogistics
Assignee: Novartis Corp
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Filing: 1977-08-18
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Granted: 1981-06-09
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Expires: 1997-08-18
Abstract
Abstract Compounds of the general formula I ##STR1## wherein one of the two radicals R 1 and R 2 denotes the acyl radical of a carboxylic acid of aromatic character and the other denotes hydrogen or optionally esterified or etherified hydroxyl, R 3 denotes hydrogen, alkyl or hydroxyalkyl, R 4 denotes optionally esterified or amidized carboxyl, m denotes 1 or 2 and n denotes 0 or 1, in the free form or in the form of their salts are useful as antiphlogistics, mild analgesics, antipyretics and as anti-rheumatic agents.
Inventors
- 👤 Georges Haas
- 👤 Alberto Rossi
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 02:05
CPC Classifications
C; C07; C07C; C07C59/00; C07C59/40; C07C59/42; C07C59/54; A; A61; A61P; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
111 words
A compound of the general formula ##STR7## wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by at least one member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid, or hydroxy etherified by a lower alkanol, R 3 denotes hydrogen, lower alkyl or lower hydroxyalkyl, R 4 denotes amidised carboxyl wherein the amino group is a member selected from di-lower alkylamino-lower alkylamino, hydroxylamino, hydrazino, mono-lower alkylamino, di-lower alkylamino and amino, m denotes 1 or 2 and n denotes 0 or 1, or therapeutically acceptable salts of said amidised carboxyl compounds.
Claim 2
Dependent Claim
111 words
A compound of the general formula ##STR7## wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by at least one member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid, or hydroxy etherified by a lower alkanol, R 3 denotes hydrogen, lower alkyl or lower hydroxyalkyl, R 4 denotes amidised carboxyl wherein the amino group is a member selected from di-lower alkylamino-lower alkylamino, hydroxylamino, hydrazino, mono-lower alkylamino, di-lower alkylamino and amino, m denotes 1 or 2 and n denotes 0 or 1, or therapeutically acceptable salts of said amidised carboxyl compounds.
Claim 3
Dependent Claim
121 words
A compound as claimed in claim 1, of the general formula I, wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid, or hydroxy etherified by a lower alkanol, in each case with up to 7 carbon atoms, R 3 denotes hydrogen, lower alkyl or a α-hydroxy-lower alkyl each with up to 4 carbon atoms, R 4 denotes amidised carboxyl wherein the amino group is a member selected from di-lower alkylamino-lower alkylamino, hydroxylamino, hydrazino, mono-lower alkylamino and di-lower alkylamino, n is 0 or 1 and m denotes 1 or 2.
Claim 4
Dependent Claim
116 words
A compound as claimed in claim 1, of the general formula I, wherein one of the two radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, and the other denotes hydrogen, hydroxy, hydroxy esterified by a lower alkanecarboxylic acid with 2 to 4 carbon atoms, or hydroxy etherified by a lower alkanol with 1 to 4 carbon atoms, R 3 denotes hydrogen or lower alkyl with up to 4 carbon atoms, R 4 denotes amidised carboxyl wherein the amino group is a member selected from hydroxylamino, hydrazino, amino, mono-lower alkylamino and di-lower alkylamino, n is 0 or 1 and m is 1.
Claim 5
Dependent Claim
59 words
A compound as claimed in claim 1, of the general formula I, wherein one of the radicals R 1 and R 2 denotes benzoyl, or benzoyl substituted by a member selected from methyl, methoxy, chlorine and tri-fluoromethyl and the other denotes hydroxy, R 3 denotes hydrogen, R 4 denotes carbamoyl, n is 0 or 1 and m is 1.
Claim 6
Dependent Claim
13 words
A compound as claimed in claim 4 and being the 5-benzoyl-6-hydroxy-indane-1-carboxylic acid amide.
Claim 7
Dependent Claim
28 words
An antiphlogistic, antirheumatic, antipyretic and mildly analgesic pharmaceutical preparation containing a correspondingly effective amount of one of the compounds mentioned in claim 1, together with a pharmaceutical excipient.
References Cited (Backward Citations)
US4007225A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-06-08 | 1984-12-08 | 1985-06-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-06-08 | 1988-12-08 | 1989-06-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-06-08 | 1992-12-08 | 1993-06-09 | $7700.00 | Window Closed / Lapsed |