Patent US4704285A successfully refreshed from Google Patents.
US4704285A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Sustained release compositions comprising hydroxypropyl cellulose ethers
Assignee: Dow Chemical Co
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Filing: 1985-11-18
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Granted: 1987-11-03
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Expires: 2005-11-18
Abstract
Abstract Solid tablets of a therapeutically active composition exhibit sustained release properties when compressed with a fine particle sized hydroxypropyl cellulose ether composition.
Inventors
- 👤 Daniel A. Alderman
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 23:25
CPC Classifications
A; A61; A61K; A61K47/00; A61K9/00; A61K9/20; A61K9/2004; A61K9/2022; A61K9/205; A61K9/2054
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
109 words
A sustained release solid tablet of a therapeutically active composition, the tablet comprising a functionally effective amount of a fine particle sized hydroxypropyl cellulose ether composition in the form of a powder, wherein the cellulose ether composition is (a) water soluble and (b) is sufficiently fine that (i) at least 50 weight percent of the particles of the cellulose ether composition can pass through a 100 mesh screen and (ii) the release of the active composition from the solid tablet is delayed longer upon contacting an aqueous acidic environment at 37° C., compared to a tablet formulated with a chemically identical but coarser particle sized hydroxypropyl cellulose ether composition.
Claim 2
Dependent Claim
109 words
A sustained release solid tablet of a therapeutically active composition, the tablet comprising a functionally effective amount of a fine particle sized hydroxypropyl cellulose ether composition in the form of a powder, wherein the cellulose ether composition is (a) water soluble and (b) is sufficiently fine that (i) at least 50 weight percent of the particles of the cellulose ether composition can pass through a 100 mesh screen and (ii) the release of the active composition from the solid tablet is delayed longer upon contacting an aqueous acidic environment at 37° C., compared to a tablet formulated with a chemically identical but coarser particle sized hydroxypropyl cellulose ether composition.
Claim 3
Dependent Claim
15 words
The tablet of claim 1, further comprising a functionally effective amount of a filler composition.
Claim 4
Dependent Claim
15 words
The tablet of claim 2, further comprising a functionally effective amount of a lubricant composition.
Claim 5
Dependent Claim
12 words
The tablet of claim 1, further comprising a hydroxypropyl methylcellulose ether composition.
Claim 6
Dependent Claim
50 words
The tablet of claim 4, wherein the hydroxypropyl methylcellulose ether composition has a hydroxypropoxyl content of between about 4 and about 12 weight percent, a methoxyl content of between about 19 and about 30 weight percent, and a 2 percent aqueous solution viscosity of between about 400 and 100,000 cps.
Claim 7
Dependent Claim
27 words
The tablet of claim 5, wherein at least 50 weight percent of the particles of the hydroxypropyl cellulose ether composition can pass through a 100 mesh screen.
Claim 8
Dependent Claim
32 words
The tablet of claim 5, wherein the hydroxypropyl cellulose ether composition comprises at least about 30 weight percent of the combined weight of hydroxypropyl cellulose ether composition and hydroxypropyl methylcellulose ether composition.
Claim 9
Dependent Claim
46 words
The tablet of claim 7, wherein at least 50 weight percent of the particles of the hydroxypropyl cellulose ether composition can pass through a 100 mesh screen, and at least 70 weight percent of the hydroxypropyl methylcellulose ether composition can pass through a 100 mesh screen.
Claim 10
Dependent Claim
46 words
The tablet of claim 8, wherein at least 50 weight percent of the particles of the hydroxypropyl cellulose ether composition can pass through a 100 mesh screen, and at least 70 weight percent of the hydroxypropyl methylcellulose ether composition can pass through a 140 mesh screen.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-11-02 | 1991-05-04 | 1991-11-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-11-02 | 1995-05-04 | 1995-11-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-11-02 | 1999-05-04 | 1999-11-03 | $7700.00 | Window Closed / Lapsed |