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US4698593A
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Apparatus and method for T1 NMR imaging using spin echo NMR responses elicited by initial excitation pulses of differing nutation values
Assignee: University of California Berkeley
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Filing: 1985-09-30
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Granted: 1987-10-06
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Expires: 2005-09-30
Abstract
Abstract NMR response data usable to form a T1 NMR image is obtained by using constant repetition rate data acquisition cycles but wherein different initial nuclei nutation angles are employed to elicit NMR spin echo signal responses. Because of the different initial nutation angles employed to elicit the NMR responses, those responses will differ in accordance with an exponential function of the T1 spin-lattice relaxation time constant of the region under test. Once such T1-dependent data is captured, the T1 time constant may be calculated or otherwise derived (e.g. by an empirical best fit to an exponential curve of known time constant) to produce a T1 value for each incremental volume element (voxel) of the volume under test (e.g. a planar volume). In this manner a visual image of the T1 NMR parameter is created when the complete array of derived T1 values is converted to gray-scale (or color) values and displayed as corresponding picture elements (pixels) in a raster-scanned CRT display or the like. Such an approach may provide a significant speed improvement in the overall data acquisition time required to derive a T1 NMR image. Such speed improvements may be especially useful where large numbers of multiple slices through the object under test are being examined.
Inventors
- 👤 Lawrence E. Crooks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:53
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/48; G01R33/50
Claims Analysis
Total Claims: 33
Claim 1
Independent Claim
174 words
An imaging NMR scanner capable of deriving T1 NMR images of selected internal regions of an object under test using r.f. NMR spin echo signals elicited therefrom, said scanner comprising: means for transmitting, during successive measurement cycles, an initial predetermined φ angle nutation pulse of NMR r.f. energy into said object followed by at least one 180° angle nutation pulse of NMR r.f. energy similarly directed for producing at least one spin echo NMR r.f. response signal from said object; means operatively associated with said means for transmitting for controlling said initial predetermined φ angle nutation pulse to have a first value φ 1 during at least one measurement cycle and a different second value φ 2 during at least one further measurement cycle; and means for detecting and analyzing the spin echo NMR r.f. response signals elicited from said object during said measurement cycles and for determining T1 NMR values for use in forming a T1 NMR image of selected internal regions of said object using said spin echo NMR r.f. response signals.
Claim 2
Dependent Claim
174 words
An imaging NMR scanner capable of deriving T1 NMR images of selected internal regions of an object under test using r.f. NMR spin echo signals elicited therefrom, said scanner comprising: means for transmitting, during successive measurement cycles, an initial predetermined φ angle nutation pulse of NMR r.f. energy into said object followed by at least one 180° angle nutation pulse of NMR r.f. energy similarly directed for producing at least one spin echo NMR r.f. response signal from said object; means operatively associated with said means for transmitting for controlling said initial predetermined φ angle nutation pulse to have a first value φ 1 during at least one measurement cycle and a different second value φ 2 during at least one further measurement cycle; and means for detecting and analyzing the spin echo NMR r.f. response signals elicited from said object during said measurement cycles and for determining T1 NMR values for use in forming a T1 NMR image of selected internal regions of said object using said spin echo NMR r.f. response signals.
Claim 3
Dependent Claim
33 words
An imaging NMR scanner as in claim 1 wherein said means for controlling causes said first value φ 1 to be approximately 90° and said second value φ 2 to be approximately 45°.
Claim 4
Dependent Claim
29 words
An imaging NMR scanner as in claim 2 wherein said means for transmitting includes means causing said successive measurement cycles to be repeated at a substantially constant repetition rate.
Claim 5
Dependent Claim
26 words
An imaging NMR scanner as in claim 3 wherein said means controlling the repetition rate of the measurement cycles controls same to be approximately 2 Hertz.
Claim 6
Dependent Claim
229 words
An imaging NMR scanner capable of providing T1 images of selected internal regions of an object under test while using substantially constant repetition intervals between measurement cycles wherein spin echo NMR r.f. signals are elicited, said scanner comprising: r.f. transmitting means for transmitting timed pulse sequences of r.f. signals including, during each of repeated substantially constant measurement cycle times, (a) an initial φ NMR nutation r.f. pulse producing a predetermined flip angle φ and (b) at least one 180° NMR nutation pulse τ seconds thereafter to elicit at least one NMR spin echo signal SE at 2τ seconds after said φ pulse; said r.f. transmitting means including means for causing said initial φ NMR nutation pulse to have a first value φ 1 , during at least a first measurement cycle and a different second value φ 2 during at least a second measurement cycle thereby giving rise to at least corresponding NMR spin echo r.f. signals SE 1 and SE 2 in respective ones of said measurement cycles, said spin echo signals SE 1 and SE 2 being different but related by at least the T1 NMR value of the region under test so as to collectively represent said T1 NMR value; and r.f. receiving and signal processing means for receiving said r.f. spin echo signals SE 1 and SE 2 for deriving said T1 NMR value therefrom.
Claim 7
Dependent Claim
229 words
An imaging NMR scanner capable of providing T1 images of selected internal regions of an object under test while using substantially constant repetition intervals between measurement cycles wherein spin echo NMR r.f. signals are elicited, said scanner comprising: r.f. transmitting means for transmitting timed pulse sequences of r.f. signals including, during each of repeated substantially constant measurement cycle times, (a) an initial φ NMR nutation r.f. pulse producing a predetermined flip angle φ and (b) at least one 180° NMR nutation pulse τ seconds thereafter to elicit at least one NMR spin echo signal SE at 2τ seconds after said φ pulse; said r.f. transmitting means including means for causing said initial φ NMR nutation pulse to have a first value φ 1 , during at least a first measurement cycle and a different second value φ 2 during at least a second measurement cycle thereby giving rise to at least corresponding NMR spin echo r.f. signals SE 1 and SE 2 in respective ones of said measurement cycles, said spin echo signals SE 1 and SE 2 being different but related by at least the T1 NMR value of the region under test so as to collectively represent said T1 NMR value; and r.f. receiving and signal processing means for receiving said r.f. spin echo signals SE 1 and SE 2 for deriving said T1 NMR value therefrom.
Claim 8
Dependent Claim
38 words
An imaging NMR scanner as in claim 5 wherein said r.f. transmitting means includes means for causing said first value φ 1 to be approximately 90° and for causing said second value φ 2 to be approximately 45°.
Claim 9
Dependent Claim
30 words
An imaging NMR scanner as in claim 6 wherein said r.f. transmitting means includes means for causing said measurement cycles to be repeated at time intervals of approximately 0.5 seconds.
Claim 10
Dependent Claim
170 words
An imaging NMR scanner for deriving at least one spin echo NMR r.f. signal from selected internal regions of an object under test in response to applied pulses of transmitted r.f. signals during each of successive measurement cycles, wherein components of said spin echo NMR r.f. signals have respective intensities exponentially dependent upon the T1 and T2 NMR parameters of the region under test and are also dependent upon the initial nutation or flip angle φ corresponding to the initial transmitted r.f. signal pulse used in each measurement cycle to elicit a spin echo response, said scanner comprising: NMR excitation means for selectively controlling said initial flip angle φ to have different values for at least some of said measurement cycles whereby data representative of at least the T1 NMR value of the region under test is provided, and NMR detection and analysis means for detecting said spin echo NMR r.f. signals during measurement cycles using different initial flip angles φ and for determining at least said T1 value therefrom.
Claim 11
Dependent Claim
170 words
An imaging NMR scanner for deriving at least one spin echo NMR r.f. signal from selected internal regions of an object under test in response to applied pulses of transmitted r.f. signals during each of successive measurement cycles, wherein components of said spin echo NMR r.f. signals have respective intensities exponentially dependent upon the T1 and T2 NMR parameters of the region under test and are also dependent upon the initial nutation or flip angle φ corresponding to the initial transmitted r.f. signal pulse used in each measurement cycle to elicit a spin echo response, said scanner comprising: NMR excitation means for selectively controlling said initial flip angle φ to have different values for at least some of said measurement cycles whereby data representative of at least the T1 NMR value of the region under test is provided, and NMR detection and analysis means for detecting said spin echo NMR r.f. signals during measurement cycles using different initial flip angles φ and for determining at least said T1 value therefrom.
Claim 12
Dependent Claim
108 words
In an imaging NMR scanner of the type which includes means which repetitively tests selected internal regions of an object by transmitting an initial NMR r.f. nutation pulse followed by at least one 180° NMR r.f. nutation pulse so as to elicit at least one NMR spin echo signal from a selected region during each of successive NMR measurement cycles, the improvement comprising: control means for causing said initial NMR r.f. nutation pulse to produce a first nutation angle φ 1 during at least one first NMR measurement cycle and to produce a different second nutation angle φ 2 during at least one other second NMR measurement cycle.
Claim 13
Dependent Claim
108 words
In an imaging NMR scanner of the type which includes means which repetitively tests selected internal regions of an object by transmitting an initial NMR r.f. nutation pulse followed by at least one 180° NMR r.f. nutation pulse so as to elicit at least one NMR spin echo signal from a selected region during each of successive NMR measurement cycles, the improvement comprising: control means for causing said initial NMR r.f. nutation pulse to produce a first nutation angle φ 1 during at least one first NMR measurement cycle and to produce a different second nutation angle φ 2 during at least one other second NMR measurement cycle.
Claim 14
Dependent Claim
28 words
An improved imaging NMR scanner as in claim 9 further comprising means for causing both of said first and second NMR measurement cycles to have approximately equal durations.
Claim 15
Dependent Claim
28 words
An improved imaging NMR scanner as in claim 9 wherein said control means causes φ 1 to be approximately 90° and causes φ 2 to be approximately 45°.
Claim 16
Dependent Claim
163 words
An imaging NMR method capable of deriving T1 NMR images of selected internal regions of an object under test using r.f. NMR spin echo signals elicited therefrom, said method comprising the steps of: tranmitting, during successive measurement cycles, an initial predetermined φ angle nutation pulse of NMR r.f. energy into said object followed by at least one 180° angle nutation pulse of NMR r.f. energy similarly directed for producing at least one spin echo NMR r.f. response signals from said object; controlling said initial predetermined φ angle nutation pulse to have a first value φ 1 during at least one measurement cycle and a different second value φ 2 during at least one further measurement cycle; and detecting and analyzing the spin echo NMR r.f. response signals elicited from said object during said measurement cycles and determining T1 NMR values for use in forming a T1 NMR image of selected internal regions of said object using said spin echo NMR r.f. response signals.
Claim 17
Dependent Claim
163 words
An imaging NMR method capable of deriving T1 NMR images of selected internal regions of an object under test using r.f. NMR spin echo signals elicited therefrom, said method comprising the steps of: tranmitting, during successive measurement cycles, an initial predetermined φ angle nutation pulse of NMR r.f. energy into said object followed by at least one 180° angle nutation pulse of NMR r.f. energy similarly directed for producing at least one spin echo NMR r.f. response signals from said object; controlling said initial predetermined φ angle nutation pulse to have a first value φ 1 during at least one measurement cycle and a different second value φ 2 during at least one further measurement cycle; and detecting and analyzing the spin echo NMR r.f. response signals elicited from said object during said measurement cycles and determining T1 NMR values for use in forming a T1 NMR image of selected internal regions of said object using said spin echo NMR r.f. response signals.
Claim 18
Dependent Claim
186 words
An imaging NMR method capable of deriving T1 NMR images of selected internal regions of an object under test using r.f. NMR spin echo signals elicited therefrom, said method comprising the steps of: transmitting, during successive measurement cycles, an initial predetermined φ angle nutation pulse of NMR r.f. energy into said object followed by at least one 180° angle nutation pulse of NMR r.f. energy similarly directed for producing at least one spin echo NMR r.f. response signal from said object; controlling said initial predetermined φ angle nutation pulse to have a first value φ 1 during at least one measurement cycle and a different second value φ 2 during at least one further measurement cycle; and detecting and analyzing the spin echo NMR r.f. response signals elicited from said object during said measurement cycles and determining T1 NMR values for use in forming a T1 NMR image of selected internal regions of said object using said spin echo NMR r.f. response signals; said controlling step causing said first value φ 1 to be approximately 90° and said second value φ 2 to be approximately 45°.
Claim 19
Dependent Claim
186 words
An imaging NMR method capable of deriving T1 NMR images of selected internal regions of an object under test using r.f. NMR spin echo signals elicited therefrom, said method comprising the steps of: transmitting, during successive measurement cycles, an initial predetermined φ angle nutation pulse of NMR r.f. energy into said object followed by at least one 180° angle nutation pulse of NMR r.f. energy similarly directed for producing at least one spin echo NMR r.f. response signal from said object; controlling said initial predetermined φ angle nutation pulse to have a first value φ 1 during at least one measurement cycle and a different second value φ 2 during at least one further measurement cycle; and detecting and analyzing the spin echo NMR r.f. response signals elicited from said object during said measurement cycles and determining T1 NMR values for use in forming a T1 NMR image of selected internal regions of said object using said spin echo NMR r.f. response signals; said controlling step causing said first value φ 1 to be approximately 90° and said second value φ 2 to be approximately 45°.
Claim 20
Dependent Claim
22 words
A method as in claim 13 wherein said transmitting step includes repeating said successive measurement cycles at a substantially constant repetition rate.
Claim 21
Dependent Claim
23 words
A method as in claim 14 wherein said controlling step causes the repetition rate of the measurement cycles to be approximately 2 Hertz.
Claim 22
Dependent Claim
214 words
An imaging NMR method capable of providing T1 images of selected internal regions of an object under test while using substantially constant repetition intervals between measurement cycles wherein spin echo NMR r.f. signals are elicited, said method comprising the steps of: transmitting timed pulse sequences of r.f. signals including, during each of repeated substantially constant measurement cycle times, (a) an initial φ NMR nutation r.f. pulse producing a predetermined flip angle φ and (b) at least one 180° NMR nutation pulse τ seconds thereafter to elicit at least one NMR spin echo signal SE at 2τ seconds after said φ pulse; controlling said initial φ NMR nutation pulse to have a first value φ 1 , during at least a first measurement cycle and a different second value φ 2 during at least a second measurement cycle thereby giving rise to at least corresponding NMR spin echo r.f. signals SE 1 and SE 2 in respective ones of said measurement cycles, said spin echo signals SE 1 and SE 2 being different but related by at least the T1 NMR value of the region under test so as to collectively represent said T1 NMR value; and receiving said r.f. spin echo signals SE 1 and SE 2 and deriving said T1 NMR value therefrom.
Claim 23
Dependent Claim
214 words
An imaging NMR method capable of providing T1 images of selected internal regions of an object under test while using substantially constant repetition intervals between measurement cycles wherein spin echo NMR r.f. signals are elicited, said method comprising the steps of: transmitting timed pulse sequences of r.f. signals including, during each of repeated substantially constant measurement cycle times, (a) an initial φ NMR nutation r.f. pulse producing a predetermined flip angle φ and (b) at least one 180° NMR nutation pulse τ seconds thereafter to elicit at least one NMR spin echo signal SE at 2τ seconds after said φ pulse; controlling said initial φ NMR nutation pulse to have a first value φ 1 , during at least a first measurement cycle and a different second value φ 2 during at least a second measurement cycle thereby giving rise to at least corresponding NMR spin echo r.f. signals SE 1 and SE 2 in respective ones of said measurement cycles, said spin echo signals SE 1 and SE 2 being different but related by at least the T1 NMR value of the region under test so as to collectively represent said T1 NMR value; and receiving said r.f. spin echo signals SE 1 and SE 2 and deriving said T1 NMR value therefrom.
Claim 24
Dependent Claim
238 words
An imaging NMR method capable of providing T1 images of selected internal regions of an object under test while using substantially constant repetition intervals between measurement cycles wherein spin echo NMR r.f. signals are elicited, said method comprising the steps of: transmitting timed pulse sequences of r.f. signals including, during each of repeated substantially constant measurement cycle times, (a) an initial φNMR nutation r.f. pulse producing a predetermined flip angle φ and (b) at least one 180° NMR nutation pulse τ seconds thereafter to elicit at least one NMR spin echo signal SE at 2τ seconds after said φ pulse; controlling said initial φ NMR nutation pulse to have a first value φ 1 , during at least a first measurement cycle and a different second value φ 2 during at least a second measurement cycle thereby giving rise to at least corresponding NMR spin echo r.f. signals SE 1 and SE 2 in respective ones of said measurement cycles, said spin echo signals SE 1 and SE 2 being different but related by at least the T1 NMR value of the region under test so as to collectively represent said T1 NMR value; and receiving said r.f. spin echo signals SE 1 and SE 2 and deriving said T1 NMR value therefrom; said controlling step incluing controlling said first value φ 1 to be approximately 90° and controlling said second value φ 2 to be approximately 45°.
Claim 25
Dependent Claim
238 words
An imaging NMR method capable of providing T1 images of selected internal regions of an object under test while using substantially constant repetition intervals between measurement cycles wherein spin echo NMR r.f. signals are elicited, said method comprising the steps of: transmitting timed pulse sequences of r.f. signals including, during each of repeated substantially constant measurement cycle times, (a) an initial φNMR nutation r.f. pulse producing a predetermined flip angle φ and (b) at least one 180° NMR nutation pulse τ seconds thereafter to elicit at least one NMR spin echo signal SE at 2τ seconds after said φ pulse; controlling said initial φ NMR nutation pulse to have a first value φ 1 , during at least a first measurement cycle and a different second value φ 2 during at least a second measurement cycle thereby giving rise to at least corresponding NMR spin echo r.f. signals SE 1 and SE 2 in respective ones of said measurement cycles, said spin echo signals SE 1 and SE 2 being different but related by at least the T1 NMR value of the region under test so as to collectively represent said T1 NMR value; and receiving said r.f. spin echo signals SE 1 and SE 2 and deriving said T1 NMR value therefrom; said controlling step incluing controlling said first value φ 1 to be approximately 90° and controlling said second value φ 2 to be approximately 45°.
Claim 26
Dependent Claim
24 words
A method as in claim 17 wherein said transmitting step causes said measurement cycles to be repeated at time intervals of approximately 0.5 seconds.
Claim 27
Dependent Claim
158 words
An imaging NMR method for deriving at least one spin echo NMR r.f. signal from selected internal regions of an object under test in response to applied pulses of transmitted r.f. signals during each of successive measurement cycles, wherein components of said spin echo NMR r.f. signals have respective intensities exponentially dependent upon the T1 and T2 NMR parameters of the region under test and upon the initial nutation or flip angle φ corresponding to the initial transmitted r.f. signal pulse used each measurement cycle to elicit a spin echo response, said method comprising the steps of: selectively controlling said initial flip angle φ to have different values for at least some of said measurement cycles whereby data representative of at least the T1 NMR value of the region under test is provided, and detecting said spin echo NMR r.f. signals during measurement cycles using different initial flip angles φ and determining at least said T1 value therefrom.
Claim 28
Dependent Claim
158 words
An imaging NMR method for deriving at least one spin echo NMR r.f. signal from selected internal regions of an object under test in response to applied pulses of transmitted r.f. signals during each of successive measurement cycles, wherein components of said spin echo NMR r.f. signals have respective intensities exponentially dependent upon the T1 and T2 NMR parameters of the region under test and upon the initial nutation or flip angle φ corresponding to the initial transmitted r.f. signal pulse used each measurement cycle to elicit a spin echo response, said method comprising the steps of: selectively controlling said initial flip angle φ to have different values for at least some of said measurement cycles whereby data representative of at least the T1 NMR value of the region under test is provided, and detecting said spin echo NMR r.f. signals during measurement cycles using different initial flip angles φ and determining at least said T1 value therefrom.
Claim 29
Dependent Claim
102 words
In an imaging NMR method of the type which repetitively tests selected internal regions of an object by transmitting an initial NMR r.f. nutation pulse followed by at least one 180° NMR r.f. nutation pulse so as to elicit at least one NMR spin echo signal from a selected region during each of successive NMR measurement cycles, the improvement comprising: controlling said initial NMR r.f. nutation pulse to produce a first nutation angle φ 1 during at least one first NMR measurement cycle and to produce a different second nutation angle φ 2 during at least one other second NMR measurement cycle.
Claim 30
Dependent Claim
102 words
In an imaging NMR method of the type which repetitively tests selected internal regions of an object by transmitting an initial NMR r.f. nutation pulse followed by at least one 180° NMR r.f. nutation pulse so as to elicit at least one NMR spin echo signal from a selected region during each of successive NMR measurement cycles, the improvement comprising: controlling said initial NMR r.f. nutation pulse to produce a first nutation angle φ 1 during at least one first NMR measurement cycle and to produce a different second nutation angle φ 2 during at least one other second NMR measurement cycle.
Claim 31
Dependent Claim
29 words
An improved imaging NMR method as in claim 20 further comprising the step of controlling both of said first and second NMR measurement cycles to have approximately equal durations.
Claim 32
Dependent Claim
114 words
In an imaging method of the type which repetitively tests selected internal regions of an object by transmitting an initial NMR r.f. nutation pulse followed by at least one 180° NMR r.f. nutation pulse so as toe elicit at least one NMR spin echo signal from a selected region during each of successive NMR measurement cycles, the improvement comprising: controlling said initial NMR r.f. nutation pulse to produce a first nutation angle φ 1 during at least one first NMR measurement cycle and to produce a different second nutation angle φ 2 during at least one other second NMR measurement cycle; said φ 1 being approximately 90° and said φ 2 being approximately 45°.
Claim 33
Dependent Claim
114 words
In an imaging method of the type which repetitively tests selected internal regions of an object by transmitting an initial NMR r.f. nutation pulse followed by at least one 180° NMR r.f. nutation pulse so as toe elicit at least one NMR spin echo signal from a selected region during each of successive NMR measurement cycles, the improvement comprising: controlling said initial NMR r.f. nutation pulse to produce a first nutation angle φ 1 during at least one first NMR measurement cycle and to produce a different second nutation angle φ 2 during at least one other second NMR measurement cycle; said φ 1 being approximately 90° and said φ 2 being approximately 45°.
References Cited (Backward Citations)
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| 3.5 Years (Year 4) | 1990-10-05 | 1991-04-06 | 1991-10-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-10-05 | 1995-04-06 | 1995-10-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-10-05 | 1999-04-06 | 1999-10-06 | $7700.00 | Window Closed / Lapsed |