US4486709A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Depth and refocusing pulses for use with inhomogeneous radiofrequency coils in nuclear magnetic resonance spectroscopy
Assignee: Varian Inc
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Filing: 1982-11-22
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Granted: 1984-12-04
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Expires: 2002-11-22
Abstract
Abstract In a pulsed nuclear magnetic resonance method of analysis, in which a single radiofrequency pulse is applied using an irradiation coil which provides an inhomogeneous radiofrequency field across the sample volume, the inhomogeneity of this field ensures that some sample regions experience a radiofrequency pulse which is closer to a π/2 pulse angle than for other regions, resulting in a larger signal intensity from the former regions as compared to the latter. If a second pulse is applied after the first, prior to acquisition of the signal, and if the phase of this pulse is alternated through the four phases: 0°, 90°, 180° and 270°, during a series of transients, then, provided the receiver phase is changed by 180° when the second pulse phase is changed by 90°, the signal intensity will accumulate from regions where the second pulse angle is π radians and there will be discrimination against regions where the second pulse angle differs markedly from π radians. This discrimination towards certain sample regions can be improved by adding further pulses after the second pulse provided the phase of each additional pulse is alternated through all four 90° phase shifts, during a series of transients, independently of the phase alternation of the other pulses, and provided that for each individual 90° phase shift, the receiver phase is changed by 180°. In its simplest form, such a series of pulses may be represented by θ;(2θ[±x,±y]) n indicating n phase alternated pulses additional to the first excitation pulse, where these additional pulses are twice as long as the first pulse.
Inventors
- 👤 Max R. Bendall
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 10:17
CPC Classifications
G; G01; G01R; G01R33/00; G01R33/20; G01R33/44; G01R33/446; G01R33/28; G01R33/32; G01R33/34; G01R33/341; G01R33/46; G01R33/465
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
143 words
A method of analysing a sample by pulsed nuclear magnetic resonance using a radiofrequency irradiation and detection coil which provides an inhomogeneous radiofrequency field, comprising reducing nuclear magnetic resonance signals from regions where a single radiofrequency pulse angle differs from π/2 radians by applying a second pulse after a first pulse prior to signal detection by a receiver, wherein the second pulse has a pulse angle twice as large as the pulse angle of the first pulse and the phase of the second pulse is alternated through all four 90° phase shifts during subsequent transients such that an equal number of transients are acquired for each of the four phase shifts, and wherein the receiver phase is inverted when the phase of the second pulse is shifted +90° or -90° relative to the phase of the second pulse used for the first transient.
Claim 2
Independent Claim
143 words
A method of analysing a sample by pulsed nuclear magnetic resonance using a radiofrequency irradiation and detection coil which provides an inhomogeneous radiofrequency field, comprising reducing nuclear magnetic resonance signals from regions where a single radiofrequency pulse angle differs from π/2 radians by applying a second pulse after a first pulse prior to signal detection by a receiver, wherein the second pulse has a pulse angle twice as large as the pulse angle of the first pulse and the phase of the second pulse is alternated through all four 90° phase shifts during subsequent transients such that an equal number of transients are acquired for each of the four phase shifts, and wherein the receiver phase is inverted when the phase of the second pulse is shifted +90° or -90° relative to the phase of the second pulse used for the first transient.
Claim 3
Dependent Claim
158 words
A method as claimed in claim 1 wherein nuclear magnetic resonance signals from regions where a single pulse angle differs from π/2 radians is reduced by the addition of one or more further pulses subsequent to the first and second pulses such that a further signal reduction is obtained for each further pulse, the pulse angles of the further pulses being twice as large as the first pulse angle and the phases of all pulses except the first being alternated through all four 90° phase shifts during a series of transients such that an equal number of transients are acquired for each of the four 90° phase shifts of each pulse during which all other pulse phases are held constant, and wherein the receiver phase is inverted whenever the total number of pulses, whose phases have been shifted by +90° or -90° relative to the phases of the pulses prior to the first transient, is an odd number.
Claim 4
Dependent Claim
203 words
A method as claimed in claim 1 wherein nuclear magnetic resonance signals from regions of the sample where a single pulse angle differs from π/2 radians is further reduced by the application of an additional pulse prior to the first and second pulses, the pulse angle of the additional pulse being twice as large as the first pulse and the phase of the first pulse being alternated between 0° and 180° in addition to the phase alternation of the second pulse such that an equal number of transients are acquired for each of the 0° and 180° pulse phases of the first pulse during which all other pulse phases are held constant and such that an equal number of transients are acquired for each of the four 90° phase shifts of the second pulse during which all other pulse phases are held constant, and wherein the receiver phase is inverted whenever the phase of the first pulse is shifted by 180° or whenever the phase of the second pulse is shifted by +90° or -90° relative to the phases of the pulses prior to the first transient but not inverted whenever both first and second pulse phases have been shifted in this way.
Claim 5
Dependent Claim
209 words
A method as claimed in claim 1 wherein nuclear magnetic resonance signals from regions of the sample where a single pulse angle differs from π/2 radians is further reduced by the application of an additional pulse prior to the first and second pulses and by the application of one or more further pulses subsequent to the first and second pulses such that a signal reduction is obtained for each additional and further pulse provided the pulse angles of the additional and further pulses are twice as large as the pulse angle of the first pulse and the phase of the first pulse is alternated between 0° and 180° and the phases of the second and further pulses are alternated through all four 90° phase shifts such that an equal number of transients are acquired for all phase combinations of the first, second and further pulses, and wherein the receiver phase is inverted for all phase combinations for which an odd number is obtained for the sum of the number of the second and further pulses having phases +90° or -90° relative to the phases for the first transient plus the number one if the first pulse has a phase of 180° relative to its phase for the first transient.
Claim 6
Dependent Claim
176 words
A method as claimed in claim 1 wherein nuclear magnetic resonance signals from regions of the sample where a single pulse angle differs from π/2 radians is further reduced by the application of an additional pulse prior to the first and second pulses, the pulse angle of the additional pulse being twice as large as the first pulse and the phase of the additional pulse being alternated between 0° and 180° in addition to the phase alternation of the second pulse such that an equal number of transients are acquired for each of the 0° and 180° pulse phases of the additional pulse during which all other pulse phases are held constant and such that an equal number of transients are acquired for each of the four 90° phase shifts of the second pulse during which all other pulse phases are held constant, and wherein the receiver phase is inverted when the phase of the second pulse is shifted by +90° or -90° relative to the phase of the second pulse used for the first transient.
Claim 7
Dependent Claim
188 words
A method as claimed in claim 1 wherein nuclear magnetic resonance signals from regions of the sample where a single pulse angle differs from π/2 radians is further reduced by the application of an additional pulse prior to the first and second pulses and by the application of one or more further pulses subsequent to the first and second pulses such that a signal reduction is obtained for each additional and further pulse provided the pulse angles of the additional and further pulses are twice as large as the pulse angle of the first pulse and the phase of the additional pulse is alternated between 0° and 180° and the phases of the second and further pulses are alternated through all four 90° phase shifts such that an equal number of transients are acquired for all phase combinations of the additional, second and further pulses, and wherein the receiver phase is inverted for all phase combinations for which an odd number is obtained for the sum of the number of the second and further pulses having phases +90° or -90° relative to the phases for the first transient.
Claim 8
Independent Claim
19 words
A method as claimed in any one of claims 1 to 6 wherein the relative pulse angles are varied.
Claim 9
Independent Claim
28 words
A method as claimed in any one of claims 1 to 6 wherein a quadrature phase compensation scheme is employed in addition to the existing phase alternation schemes.
Claim 10
Independent Claim
53 words
A method as claimed in any one of claims 1 to 6 wherein in substitution for any pulse-phase combination which is accompanied by inversion of receiver phase, a pulse-phase combination having all pulse-phases inverted relative to the original pulse-phase combination is used, and wherein the same receiver phase is used for all transients.
Claim 11
Dependent Claim
82 words
A method as claimed in claim 1 or 2 wherein delay periods of any magnitude may be used between the pulses wherein the total delay period between the first pulse and the beginning of acquisition is divisible into a number of delay periods which equals the number of pulses after the first pulse such that each pulse after the first pulse is at the centre of one of these delay periods, and wherein some of these delay periods may have zero time.
Claim 12
Independent Claim
102 words
A method as claimed in any one of claims 3 to 6 wherein delay periods of any magnitude may be used between the pulses, wherein the total delay period between the second pulse and the beginning of acquisition is divisible into a number of delay periods which equals the number of pulses after the first pulse such that each pulse after the first pulse is at the centre of one of these delay periods, wherein some of these delay periods may have zero time and wherein a delay period of any magnitude may be used between the additional and the first pulse.
Claim 13
Independent Claim
48 words
A method as claimed in any one of claims 1 to 6 when applied to any spin-echo application provided that one or more of the pulses which are alternated through all four 90° phase shifts are placed at the centre or centres of the spin-echo period or periods.
Claim 14
Independent Claim
35 words
A method as claimed in any one of claims 3 to 6 when applied to inversion-recovery T 1 measurements provided that the incremented relaxation delay period is placed between the additional and the first pulse.
Claim 15
Independent Claim
92 words
A method as claimed in any one of claims 1 to 6 wherein in substitution for any pulse-phase combination which is accompanied by inversion of receiver phase, a pulse-phase combination having all pulse-phases inverted relative to the original pulse-phase combination is used, wherein the same receiver phase is used for all transients, and when this method is applied to any spin-echo application provided that one or more of the pulses which are alternated through all four 90° phase shifts are placed at the centre or centres of the spin-echo period or periods.
Claim 16
Independent Claim
79 words
A method as claimed in any one of claims 3 to 6 wherein in substitution for any pulse-phase combination which is accompanied by inversion of receiver phase, a pulse-phase combination having all pulse-phases inverted relative to the original pulse-phase combination is used, wherein the same receiver phase is used for all transients, and when this method is applied to inversion-recovery T 1 measurements provided that the incremented relaxation delay period is placed between the additional and the first pulse.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-12-04 | 1988-06-04 | 1988-12-04 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-12-04 | 1992-06-04 | 1992-12-04 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-12-04 | 1996-06-04 | 1996-12-04 | $7700.00 | Window Closed / Lapsed |