Delivery system for active ingredients and preparation thereof

Claim 2

a process of preparing a particulate delivery system comprising: (i) forming an aqueous suspension of an insolubilized active ingredient and a monovalent cation salt of an algin or carageenen, wherein the insolubilized active ingredient is selected from the group consisting of drugs, favors, coloring agents, sweetening agents, perfumes, bulking agents and mixtures thereof; (ii) combining the aqueous suspension of the insolubilized active ingredient with a precipitate initiating material to form a polymeric matrix entrapping said active with the matrix interstices; (iii) rcovering the resultant product and drying to yield the delivery system.

Claim 3

The process of claim 1 wherein the precipitate initiating material contains a multivalent cation.

Claim 4

The process of claim 1 wherein the precipitate initiating material comprises an acid.

Claim 5

The process of claim 2 wherein the precipitate initiating material is selected from the group consisting of aluminum, calcium, copper, magnesium, zinc, manganese, iron and mixtures thereof.

Claim 6

The process of claim 4 wherein the precipitate initiating material is in solution prior to addition to the suspension of (i).

Claim 7

The process of claim 3 wherein the precipitate initiating material is selected from the group consisting of hydrochloric acid, nitric acid and sulfuric acid.

Claim 8

The process of claim 1 wherein the flavoring agent is selected from the group consisting of spearmint oil, cinnamon oil, oil of wintergreen (methy salicylate), peppermint oil, citrus oil, fruit essences, cinnamyl acetate, cinnamaldehyde, citral diethylacetal, dihyrocarvyl acetate, eugenyl formate, p-methyl-amisol and mixtures thereof.

Claim 9

The process of claim 1 wherein the drug is selected from the group consisting of mineral supplements, analgesics, antipyretics, antiarrhythmics, ion exchange resins, appetite supressants, vitamins, antiinflammatory substances, coronary dilators, cerebral dilators, peripheral vasodilators, anti-infectives, psychotropics, antimanics, stimulants, antihistamines, laxatives, decongestants, gastro-intestinal sedatives, antidiarrheal preparations, anti-anginal drugs, vasodilators, anti-hypertensive drugs, vasoconstrictors and migrane treatments, antibiotics, tranquilizers, antipsychotics, antitumor drugs, anticoagulants and antithrombotic drugs, hypnotics, sedatives, anti-emetics, anti-nauseants, anticonvulsants, neuromuscular drugs, hyper- and hypoglycaemic agents, thyroid and antithyroid preparations, diuretics, antispasmodics, uterine relaxants, mineral and nutritional additives, antiobesity drugs, anabolic drugs, erythropoietic drugs, antiasthmatics, expectorants, cough suppressants, mucolytics, anti-uricemic drugs and mixtures thereof.

Claim 10

The process of claim 4 wherein the sweetening agents are selected from the group consisting of natural sweeteners and artificial sweeteners.

Claim 11

The process of claim 1 wherein the ratio of active ingredient to precipitate is about 5:1 to about 1:2.

Claim 12

The process of claim 10 wherein the ratio of active ingredient to precipitate is about 2:1 to about 1:1.

Claim 13

The process of claim 1 wherein the temperature of the aqueous suspension is such that the active ingredient neither crystallizes nor evaporates appreciably.

Claim 14

The process of claim 1 wherein the precipitated product is freeze dried and then thawed to form the delivery system.

Claim 15

The process of claim 1 wherein the precipitated product is freeze dried followed by air drying to form the delivery system.

Claim 16

A delivery system comprising: (a) an insolubolized active ingredient; and (b) a cross-linked multivalent cation alginate or multivalent cation carageenenate matrix; said delivery system prepared by the process of: (i) forming an aqueous suspension of the insolubolized active ingredient and a monovalent cation salt of an algin or carageenen; (ii) combining the aqueous suspension of the insolubolized active ingredient with a precipitate initiating material; and (iii) recovering a precipitated product and drying to form the delivery system.

Claim 17

A delivery system comprising: (a) an insolubolized active ingredient; and (b) a cross-linked multivalent cation alginate or multivalent cation carageenenate matrix; said delivery system prepared by the process of: (i) forming an aqueous suspension of the insolubolized active ingredient and a monovalent cation salt of an algin or carageenen; (ii) combining the aqueous suspension of the insolubolized active ingredient with a precipitate initiating material; and (iii) recovering a precipitated product and drying to form the delivery system.

Claim 18

The delivery system of claim 15 wherein the insolubolized active ingredient is selected from the group consisting of flavor agents, drugs, a coloring agent, perfumes, sweetening agents, bulking agents and mixtures thereof.

Claim 19

The delivery system of claim 15 wherein the precipitate initiating material is a multivalent cation or an acid.

Claim 20

The delivery system of claim 15 wherein the multivalent cation is selected from the group consisting of the salts of aluminum, calcium, copper, magnesium, zinc, iron, manganese, and mixtures thereof.

Claim 21

The delivery system of claim 17 wherein the multivalent cation salt is in aqueous solution.

Claim 22

A delivery system comprising: (a) an insolubolized active ingredient selected from the group consisting of flavoring agents, drugs, coloring agents, sweetening agents, perfumes, bulking agents and mixtures thereof; and (b) a cross-linked multivalent cation alginate or multivalent cation carageenenate matrix entrapping said insolubolized active ingredient.

Claim 23

A delivery system comprising: (a) an insolubolized active ingredient selected from the group consisting of flavoring agents, drugs, coloring agents, sweetening agents, perfumes, bulking agents and mixtures thereof; and (b) a cross-linked multivalent cation alginate or multivalent cation carageenenate matrix entrapping said insolubolized active ingredient.

Claim 24

The delivery system of claim 20 wherein the multivalent cation alginate or carageenenate is selected from the group consisting of the salts of aluminum, iron, calcium, copper, magnesium, zinc, manganese and mixtures thereof.

Claim 25

The delivery system of claim 20 wherein the particle size of the active ingredient is about 1 to about 10 microns.

Claim 26

The delivery system of claim 20 wherein the ratio of active ingredient to matrix material is about 5:1 to about 1:2.

Claim 27

A chewing gum composition containing the delivery system of claim 20.

Claim 28

A pharmaceutical preparation containing the delivery system of claim 20.

Claim 29

A denture adhesive containing the delivery system of claim 20.