US4505935A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Protective layer on skin, mucous membrane or other body tissue
Assignee: Individual
•
Filing: 1982-08-20
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Granted: 1985-03-19
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Expires: 2002-08-20
Abstract
Abstract A layer can be formed on skin, mucous membrane or other tissue by first applying an ointment on the skin or mucous membrane, said ointment containing a water-soluble alginate and an aqueous dispersion of hydrophilic lipid crystals. A calcium salt is then applied on the surface of the ointment, which converts the alginate to insoluble calcium salt. Pharmaceutically active components may be included in the ointment.
Inventors
- 👤 Viktor K. Larsson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-01 19:32
CPC Classifications
A; A61; A61Q; A61Q17/00; A61K; A61K8/00; A61K8/18; A61K8/72; A61K8/73; A61K8/733; A61L; A61L26/00; A61L26/0009; A61L26/0023
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
194 words
A method of producing a protective layer on a surface selected from the group consisting of skin and mucous membrane, said method comprising providing an ointment which comprises 70-90 percent by weight of an aqueous phase, 1-7 percent by weight of a water soluble salt of alginic acid having an average molecular weight of from 15,000 to 90,000 and 8-25 percent by weight of hydrophilic lipid crystals dispersed in said aqueous phase, said hydrophilic lipid crystals being selected from the group consisting of an alpha monoglyceride of a saturated fatty acid having 12-18 carbon atoms in the carbon chain, a glycerol monoether of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and an alkali metal salt of a phosphate ester of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, applying said ointment to said surface, and contacting said ointment on said surface with an aqueous solution of a water-soluble calcium salt, said solution containing a concentration of calcium salt sufficient to convert at least said water soluble salt in the upper portion of said ointment on said surface to an insoluble calcium salt of alginic acid.
Claim 2
Independent Claim
194 words
A method of producing a protective layer on a surface selected from the group consisting of skin and mucous membrane, said method comprising providing an ointment which comprises 70-90 percent by weight of an aqueous phase, 1-7 percent by weight of a water soluble salt of alginic acid having an average molecular weight of from 15,000 to 90,000 and 8-25 percent by weight of hydrophilic lipid crystals dispersed in said aqueous phase, said hydrophilic lipid crystals being selected from the group consisting of an alpha monoglyceride of a saturated fatty acid having 12-18 carbon atoms in the carbon chain, a glycerol monoether of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and an alkali metal salt of a phosphate ester of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, applying said ointment to said surface, and contacting said ointment on said surface with an aqueous solution of a water-soluble calcium salt, said solution containing a concentration of calcium salt sufficient to convert at least said water soluble salt in the upper portion of said ointment on said surface to an insoluble calcium salt of alginic acid.
Claim 3
Dependent Claim
40 words
The method of claim 1 wherein said hydrophilic lipid crystals consist of thin leaves having on their surface a substantially monomolecular layer in which polar end groups face outwardly toward the surface of the crystal to provide a hydrophilic characteristic.
Claim 4
Dependent Claim
45 words
The method of claim 1 wherein said ointment comprises 1 part by weight of an aqueous suspension containing 10-40 percent by weight of hydrophilic lipid crystals and 0.5-4 parts by weight of an aqueous solution containing 3-8 percent by weight of said alginic acid salt.
Claim 5
Dependent Claim
12 words
The method of claim 1 wherein said calcium salt comprises calcium acetate.
Claim 6
Dependent Claim
24 words
The method of claim 1 wherein the calcium salt is applied in the form of an aqueous solution comprising 10-30 percent of calcium salt.
Claim 7
Dependent Claim
117 words
An ointment comprising 70-90 percent by weight of an aqueous phase, 8-25 percent by weight of hydrophilic lipid crystals dispersed in said aqueous phase, said lipid crystals being selected from the group consisting of an alpha monoglyceride of a saturated fatty acid having 12-18 carbon atoms in the carbon chain, a glycerol monoether of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and an alkali metal salt of a phosphate ester of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and 1-7 percent by weight of a water-soluble salt of alginic acid dissolved in said aqueous phase, said salt having an average molecular weight of from 15,000 to 90,000.
Claim 8
Dependent Claim
117 words
An ointment comprising 70-90 percent by weight of an aqueous phase, 8-25 percent by weight of hydrophilic lipid crystals dispersed in said aqueous phase, said lipid crystals being selected from the group consisting of an alpha monoglyceride of a saturated fatty acid having 12-18 carbon atoms in the carbon chain, a glycerol monoether of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and an alkali metal salt of a phosphate ester of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and 1-7 percent by weight of a water-soluble salt of alginic acid dissolved in said aqueous phase, said salt having an average molecular weight of from 15,000 to 90,000.
Claim 9
Dependent Claim
231 words
A two component composition for producing a protective layer on a surface selected from the group consisting of skin and mucous membrane, a first component in the form of an ointment comprising 70-90 percent by weight of an aqueous phase, 1-7 percent by weight of a soluble salt of alginic acid having an average molecular weight of 15,000 to 90,000 and 8-25 percent by weight of hydrophilic lipid crystals dispersed in said aqueous phase, said hydrophilic lipid crystals being selected from the group consisting of an alpha monoglyceride of a saturated fatty acid having 12-18 carbon atoms in the carbon chain, a glycerol monoether of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and an alkali metal salt of a phosphate ester of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, said ointment being intended for application on said surface, and a second component comprising an aqueous solution of a water-soluble calcium salt for use in converting said water soluble salt to an insoluble calcium salt of alginic acid, said second component being intended for application on top of said ointment after said ointment has been applied to said surface, the concentration of said water-soluble calcium salt being sufficient to convert at least said soluble alginic acid salt in the upper portion of the ointment on said surface to said insoluble calcium salt.
Claim 10
Dependent Claim
231 words
A two component composition for producing a protective layer on a surface selected from the group consisting of skin and mucous membrane, a first component in the form of an ointment comprising 70-90 percent by weight of an aqueous phase, 1-7 percent by weight of a soluble salt of alginic acid having an average molecular weight of 15,000 to 90,000 and 8-25 percent by weight of hydrophilic lipid crystals dispersed in said aqueous phase, said hydrophilic lipid crystals being selected from the group consisting of an alpha monoglyceride of a saturated fatty acid having 12-18 carbon atoms in the carbon chain, a glycerol monoether of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, and an alkali metal salt of a phosphate ester of a saturated fatty alcohol having 12-18 carbon atoms in the carbon chain, said ointment being intended for application on said surface, and a second component comprising an aqueous solution of a water-soluble calcium salt for use in converting said water soluble salt to an insoluble calcium salt of alginic acid, said second component being intended for application on top of said ointment after said ointment has been applied to said surface, the concentration of said water-soluble calcium salt being sufficient to convert at least said soluble alginic acid salt in the upper portion of the ointment on said surface to said insoluble calcium salt.
References Cited (Backward Citations)
GB191226987A
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GB322607A
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GB342947A
Cited
DE569520C
Cited
DE932817C
Cited
GB1050967A
Cited
FR1367858A
Cited
DK75090A
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-03-18 | 1988-09-17 | 1989-03-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-03-18 | 1992-09-17 | 1993-03-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-03-18 | 1996-09-17 | 1997-03-19 | $7700.00 | Window Closed / Lapsed |