Therapeutic effervescent composition

Claim 1

A rapid dissolving therapeutic effervescent composition which comprises: (1) a preblended mixture present in an amount from about 7 to about 57.5% by weight of (A) a granulated therapeutic agent having a particle size of about 100 to about 600 microns, wherein the granulated therapeutic agent comprises a therapeutic agent present in an amount from about 2% to about 27% by weight selected from the group consisting of acetaminophen, aspirin, ibuprofen and mixtures thereof, and a water soluble granulating agent present in an amount from about 0.03 to about 2.5% by weight, being compatible with the therapeutic agent and having a viscosity below 100 cps, 10% by weight, at 25° C. in water, and (B) a component of an effervescent system having a particle size of about 50 to about 600 microns, present in an amount from about 5% to about 30% by weight said component being selected from the group consisting of a carbonate, an acid and mixtures thereof, and (2) an effervescent system present in an amount from about 42.5% to about 90% by weight wherein the effervescent system comprises a carbonate containing material and an acid, all percentages are by weight of the total effervescent composition.

Claim 12

A method for preparing a rapidly dissolving effervescent composition of a therapeutic agent which comprises: (A) forming a granulation by dissolving a granulating agent in a solvent to form a solution containing from about 1 to about 50% by weight granulating agent, and mixing a therapeutic agent with the solution, (B) drying the granulation, (C) sizing the dried granulation by grinding and screening to obtain particles having a size of about 100 to about 600 microns. (D) admixing a component of an effervescent system having a particle size from about 50 to about 600 microns with the sized granulation of step (C) to form a mixture, (E) mixing an effervescent system with the mixture of step (D) to obtain a uniform mixture of granules and recovering the product, wherein said therapeutic agent is selected from the group consisting of acetaminophen, aspirin, ibuoprofen and mixtures thereof, and said granulating agent being compatible with the therapeutic agent, and is water soluble having a viscosity below 100 cps, 10% by weight, at 25° C. in water.

Claim 13

A method for preparing a rapidly dissolving effervescent composition of a therapeutic agent which comprises: (A) forming a granulation by dissolving a granulating agent in a solvent to form a solution containing from about 1 to about 50% by weight granulating agent, and mixing a therapeutic agent with the solution, (B) drying the granulation, (C) sizing the dried granulation by grinding and screening to obtain particles having a size of about 100 to about 600 microns. (D) admixing a component of an effervescent system having a particle size from about 50 to about 600 microns with the sized granulation of step (C) to form a mixture, (E) mixing an effervescent system with the mixture of step (D) to obtain a uniform mixture of granules and recovering the product, wherein said therapeutic agent is selected from the group consisting of acetaminophen, aspirin, ibuoprofen and mixtures thereof, and said granulating agent being compatible with the therapeutic agent, and is water soluble having a viscosity below 100 cps, 10% by weight, at 25° C. in water.