US4093710A — Rapid dissolving effervescent granules

Claim 1

Independent Claim 233 words

A method of preparing stable, free flowing, rapid dissolving, palatable effervescent granules having essentially the following composition per unit dose: ______________________________________ Active ingredient suitable for administration orally in an Therapeutically effective effervescent drink amount Alkali metal carbonate or bicarbonate 0.200 Gm. - 2.000 Gm. Organic Acid, Anhydrous granule 0.200 Gm. - 2.000 Gm. Sweetener 0.005 Gm. - 0.100 Gm. Surfactant 0.002 Gm. - 0.070 Gm. Flavor q.s. ______________________________________ which comprises: (a) grinding the active ingredients, alkali metal carbonate, and sweetener to a mesh size of less than 80; (b) mixing the active ingredient, alkali metal carbonate, and sweetener in a mixer to form a uniform mixture and granulating the mixture with a 1 percent to 25 percent by weight solution of the surfactant in water to form fine granules having a mesh size between #10 and #80; (c) drying the granules at a temperature between 65° F. and 200° F. to a moisture level of less than 0.5 percent; (d) sizing the granulation by grinding and screening to obtain particles having a particle size of less than 20 mesh; (e) sizing the organic acid to obtain particles having a particle size of less than 20 mesh; (f) milling the flavors to a particle size of less than 80 mesh; and (g) blending the granulation of Step (d) with the acid and flavors of Steps (e) and (f) to obtain a uniform granule mixture.

Claim 2

Independent Claim 233 words

A method of preparing stable, free flowing, rapid dissolving, palatable effervescent granules having essentially the following composition per unit dose: ______________________________________ Active ingredient suitable for administration orally in an Therapeutically effective effervescent drink amount Alkali metal carbonate or bicarbonate 0.200 Gm. - 2.000 Gm. Organic Acid, Anhydrous granule 0.200 Gm. - 2.000 Gm. Sweetener 0.005 Gm. - 0.100 Gm. Surfactant 0.002 Gm. - 0.070 Gm. Flavor q.s. ______________________________________ which comprises: (a) grinding the active ingredients, alkali metal carbonate, and sweetener to a mesh size of less than 80; (b) mixing the active ingredient, alkali metal carbonate, and sweetener in a mixer to form a uniform mixture and granulating the mixture with a 1 percent to 25 percent by weight solution of the surfactant in water to form fine granules having a mesh size between #10 and #80; (c) drying the granules at a temperature between 65° F. and 200° F. to a moisture level of less than 0.5 percent; (d) sizing the granulation by grinding and screening to obtain particles having a particle size of less than 20 mesh; (e) sizing the organic acid to obtain particles having a particle size of less than 20 mesh; (f) milling the flavors to a particle size of less than 80 mesh; and (g) blending the granulation of Step (d) with the acid and flavors of Steps (e) and (f) to obtain a uniform granule mixture.

Claim 3

Dependent Claim 23 words

The method according to claim 1 in which the alkali metal carbonate is a sodium or potassium carbonate or bicarbonate or mixtures thereof.

Claim 4

Dependent Claim 41 words

The method according to claim 1 in which the particles of Step (d) have the following particle size distribution: ______________________________________ PERCENT RANGE MESH RANGE ______________________________________ 0 Larger than 20 50-95 20-80 5-40 100-200 Less than 10 percent Smaller than 200. ______________________________________

Claim 5

Dependent Claim 40 words

The method according to claim 1 in which the particles of Step (e) have the following particle size distribution: ______________________________________ PERCENT RANGE MESH RANGE ______________________________________ 0 Larger than 20 50-95 20-80 5-40 100-200 Less than 20 Smaller than 200. ______________________________________

Claim 6

Dependent Claim 272 words

A method according to claim 1 of preparing a free flowing, rapid dissolving, palatable effervescent potassium chloride supplement in granule form having the following composition per unit dose: ______________________________________ Lysine Hydrochloride 0.700 Gm.-3.000 Gm. Potassium chloride, U.S.P. 0.500 Gm.-2.500 Gm. Potassium Bicarbonate, U.S.P. 0.200 Gm.-2.000 Gm. Citric Acid, U.S.P., Anhydrous 0.200 Gm.-2.000 Gm. Sweetener 0.005 Gm.-0.100 Gm. Polyethylene Glycol 0.010 Gm.-0.070 Gm. Flavor q.s. ______________________________________ which comprises: (a) grinding the amino acid hydrochloride, potassium chloride, potassium bicarbonate, and sweetener to a mesh size of less than 80; (b) mixing the amino acid hydrochloride, potassium chloride, potassium bicarbonate, and sweetener in a mixer to form a uniform mixture and granulating the mixture with a 1 percent to 25 percent by weight solution of the polyethylene glycol in water to form fine granules having a mesh size between 10 and 80; (c) drying the granules at a temperature between 65° F. and 200° F. to a moisture level of less than 0.5 percent; (d) sizing the granulation by grinding and screening to obtain particles having the following particle size distribution: ______________________________________ PERCENT RANGE MESH RANGE ______________________________________ 0 Larger than 20 50-95 20-80 5-40 100-200 Less than 10 percent Smaller than 200 ______________________________________ (e) sizing the citric acid to obtain particles having the following particle size distribution: ______________________________________ PERCENT RANGE MESH RANGE ______________________________________ 0 Larger than 20 50-95 20-80 5-40 100-200 Less than 20 Smaller than 200 ______________________________________ (f) milling the flavor to a particle size of less than 80 mesh; and (g) blending the granulation of Step d) with the acid and flavor of Steps e) and f) to obtain a uniform granule mixture.

Claim 7

Dependent Claim 12 words

The method according to claim 5 in which the sweetener is saccharin.

Claim 8

Dependent Claim 15 words

The method according to claim 5 in which the polyethylene glycol is polyethylene glycol 1540.

Claim 9

Dependent Claim 89 words

A stable free flowing, rapid dissolving, palatable effervescent composition having essentially the following components and quantities per unit dose: ______________________________________ Active ingredient suitable for administration orally in an Therapeutically effervescent drink effective amount ______________________________________ Alkali metal carbonate 0.200 Gm.-2.000 Gm. Organic Acid, Anhydrous granule 0.200 Gm.-2.000 Gm. Sweetener 0.005 Gm.-0.100 Gm. Surfactant 0.002 Gm.-0.070 Gm. Flavor q.s. ______________________________________ in the form of granules having a particle size of less than 20 mesh which dissolve in water in approximately one minute prepared in accordance with the process of claim 1.

Claim 10

Dependent Claim 18 words

The composition of claim 8 in which the alkali metal carbonate is sodium or potassium carbonate or bicarbonate.

Claim 11

Dependent Claim 74 words

The composition of claim 9 having the following components and quantities per unit dose: ______________________________________ Lysine Hydrochloride 0.700 Gm.-3.000 Gm. Potassium chloride, U.S.P. 0.500 Gm.-2.500 Gm. Potassium Bicarbonate, U.S.P. 0.200 Gm.-2.000 Gm. Citric Acid, U.S.P., Anhydrous 0.200 Gm.-2.000 Gm. Sweetener 0.005 Gm.-0.100 Gm. Polyethylene Glycol 0.010 Gm.-0.070 Gm. Flavor q.s. ______________________________________ in the form of granules having a particle size of less than 20 mesh which dissolve in drinking water in approximately 1 minute.

Claim 12

Dependent Claim 14 words

The composition of claim 10 in which the polyethylene glycol is polyethylene glycol 1540.

Claim 13

Dependent Claim 11 words

The composition of claim 10 in which the sweetener is saccharin.

Claim 14

Dependent Claim 38 words

The composition of claim 10 in which the granules have essentially the following particle size distribution: ______________________________________ PERCENT RANGE MESH RANGE ______________________________________ 0 Larger than 20 50-95 20-80 5-40 100-200 Less than 10 percent Smaller than 200. ______________________________________

Claim 15

Dependent Claim 51 words

The composition of claim 10 in which the composition has essentially the following quantities of components per unit dose: ______________________________________ L-lysine hydrochloride 913 mg. Potassium chloride 1125 mg. Potassium Bicarbonate 500 mg. Saccharin 35 mg. Polyethylene glycol-1540 31 mg. Black Cherry Flavor (Firmenich 57.423/AP/05.51) 10 mg. Citric Acid 550 mg. ______________________________________

Claim 16

Dependent Claim 21 words

The composition of claim 8 in which the surfactant is polyethylene glycol having a molecular weight of from 400 to 9000.

Claim 17

Dependent Claim 19 words

The composition of claim 10 in which the polyethylene glycol has a molecular weight of from 1000 to 6000.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1981-06-05	1981-12-05	1982-06-06	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1985-06-05	1985-12-05	1986-06-06	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1989-06-05	1989-12-05	1990-06-06	$7700.00	Window Closed / Lapsed

Rapid dissolving effervescent granules

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