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US4680390A
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Esters of 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]-3-methyl-ceph-3-em-4-carboxylic acid
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1984-10-04
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Granted: 1987-07-14
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Expires: 2004-10-04
Abstract
Abstract The compounds are of the class of esters of 7-[2-(2-aminothiazol-4-yl-)-2-(syn)methoxyiminoacetamido] cephalosporin derivatives, including lower alkoxymethyl, α-lower alkoxy-α-substituted methyl, lower alkylthiomethyl, acyloxymethyl, ethoxycarbonyloxy-1-methylmethyl and α- acyloxy-α-substituted methyl esters. The compounds are useful against a broad spectrum of bacteria, particularly gram-negative bacteria, and may be administered in the form of injections, capsules, tablets and granules.
Inventors
- 👤 Michihiko Ochiai
- 👤 Akira Morimoto
- 👤 Yoshihiro Matsushita
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 06:37
CPC Classifications
C; C07; C07D; C07D257/00; C07D257/02; C07D257/04; C07D277/00; C07D277/02; C07D277/20; C07D277/587
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
46 words
An ester selected from the group consisting of lower alkoxymethyl, 1-lower alkoxyethyl, lower alkylthiomethyl, pivaloyloxymethyl, acetoxymethyl, 1-acetoxyethyl and 1-ethoxycarbonyloxyethyl esters of a 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivative of the formula: ##STR92## wherein R 3 is hydrogen and R 2 NH is an amino group which may optionally be protected.
Claim 2
Dependent Claim
46 words
An ester selected from the group consisting of lower alkoxymethyl, 1-lower alkoxyethyl, lower alkylthiomethyl, pivaloyloxymethyl, acetoxymethyl, 1-acetoxyethyl and 1-ethoxycarbonyloxyethyl esters of a 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]cephalosporin derivative of the formula: ##STR92## wherein R 3 is hydrogen and R 2 NH is an amino group which may optionally be protected.
Claim 3
Dependent Claim
11 words
A compound as claimed in claim 1, which is pivaloyloxymethyl 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]desacetoxycephalosporanate.
Claim 4
Dependent Claim
11 words
A compound as claimed in claim 1, which is 1-Ethoxycarbonyloxyethyl 7-[2-(2-aminothiazol-4-yl)-2-(syn)-methoxyiminoacetamido]desacetoxycephalosporanate.
References Cited (Backward Citations)
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Cited
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US4092476A
Cited
US4041161A
Cited
US4098888A
Cited
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-13 | 1991-01-12 | 1991-07-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-13 | 1995-01-12 | 1995-07-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-13 | 1999-01-12 | 1999-07-14 | $7700.00 | Window Closed / Lapsed |