Patent EP0179160A1 successfully refreshed from Google Patents.
US4092476A
Expired / Lapsed
US
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Phthalidyl esters of 7-[(α amino, 2 substituted acetamido)-3-(heterocyclic-thio methyl)]cephalosporins
Assignee: Beecham Group PLC
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Filing: 1976-12-29
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Granted: 1978-05-30
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Expires: 1996-12-29
Abstract
Abstract Phthalidyl and substituted phthalidyl esters of certain cephalosporins are absorbed by the oral route into the serum, where they are hydrolyzed to the parent antibacterially active cephalosporin.
Inventors
- 👤 Peter Hubert Bentley
- 👤 John Peter Clayton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 10:02
CPC Classifications
C; C07; C07D; C07D501/00; C07D501/14; C07D501/16; C07D501/20; C07D501/24; C07D501/36; C07D501/26
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
57 words
A cephalosporin ester of the formula ##STR9## or a pharmaceutically acceptable acid addition salt thereof, wherein R is phenyl, 4-hydroxyphenyl, 3-chloro-4-hydrophenyl, 2- or 3-thienyl or dihydrophenyl; X is a heterocyclic thio group selected from the group consisting of ##STR10## (2-methyl-1,3,4-thiadiazol-5-yl) thio, (1-methyl-(1H)-1,2,3,4-tetrazol-5-yl) thio and (1H-1,3,4-triazol-5yl) thio; and R 1 and R 2 are both hydrogen or methoxy.
Claim 2
Dependent Claim
57 words
A cephalosporin ester of the formula ##STR9## or a pharmaceutically acceptable acid addition salt thereof, wherein R is phenyl, 4-hydroxyphenyl, 3-chloro-4-hydrophenyl, 2- or 3-thienyl or dihydrophenyl; X is a heterocyclic thio group selected from the group consisting of ##STR10## (2-methyl-1,3,4-thiadiazol-5-yl) thio, (1-methyl-(1H)-1,2,3,4-tetrazol-5-yl) thio and (1H-1,3,4-triazol-5yl) thio; and R 1 and R 2 are both hydrogen or methoxy.
Claim 3
Dependent Claim
16 words
A compound according to claim 1 wheren X is (2-methyl-1,3,4-thiadiazol-5-yl) thio, (1-methyl-(1H)-1,2,3,4-tetrazol-5-yl) thio or (1H-1,3,4-triazol-5-yl) thio.
Claim 4
Dependent Claim
9 words
The compound according to claim 1 which is phthalidyl-7-[D-α-aminophenylacetamido)-3-(2'-methyl-1',3',4'-thiadiazol-5'-yl)-thiomethyl]-ceph-3-em-carboxylate.
Claim 5
Dependent Claim
9 words
The compound according to claim 1 which is 5',6'-dimethoxyphthalidyl-7-[D-α-aminophenylacetamide-3-(2'-methyl-1',3',4'-thiadiazol-5-yl)-thiomethyl]-ceph-3-em-4-carboxylate.
Claim 6
Dependent Claim
9 words
The compound according to claim 1 which is phthalidyl-7-[D-α-aminophenylacetamido-3-(1'-methyl'1'-H-tetrazol-5-yl)-thiomethyl]-ceph-3-em-4-carboxylate.
Claim 7
Dependent Claim
39 words
A cephalosporin ester according to claim 1 in the form of an acid addition salt selected from the group consisting of the sulphate, nitrate, phosphate, borate, hydrochloride, hydrobromide, hydroiodide, acetate, oxalate, tartrate, maleate, citrate, succinate, benzoate, ascorbate and methanesulphonate.
References Cited (Backward Citations)
US3951954A
Cited
US3963704A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-05-29 | 1981-11-28 | 1982-05-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-05-29 | 1985-11-28 | 1986-05-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-05-29 | 1989-11-28 | 1990-05-30 | $7700.00 | Window Closed / Lapsed |