US4678671A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Conjugates of anticoagulant and protein
Assignee: Cordis Europa NV
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Filing: 1986-09-09
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Granted: 1987-07-07
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Expires: 2006-09-09
Abstract
Abstract Conjugates are provided which are covalently bonded conjugates of an anticoagulant and protein that are prepared in the presence of a coupling agent that forms amide linkages between the anticoagulant and the protein. Such amide linking coupling agents exclude highly toxic coupling agents such as CNBr. These conjugates are useful for enhancing the blood compatibility of certain surfaces of a prosthetic device, a surgical apparatus, or an extra-corporeal medical device.
Inventors
- 👤 Jan Feijen
- 👤 Wilhelmus E. Hennink
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:41
CPC Classifications
A; A61; A61L; A61L33/00; A61L33/0005; A61L33/0011; C; C08; C08B; C08B37/00; C08B37/006; C08B37/0063; C08B37/0075; C08B37/0081; C08H; C08H1/00; Y; Y10; Y10T; Y10T428/00; Y10T428/24; Y10T428/24355; Y10T428/29; Y10T428/2913; Y10T428/2933
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
55 words
An article including a surface having an enhanced blood compatibility coating, wherein the coating is effected from a conjugate of anticoagulant and a water soluble protein, said protein being a non-crosslinked protein or a crosslinked protein, said conjugate having been formed by coupling a protein component and an anticoagulant with an amide bond forming agent.
Claim 2
Dependent Claim
55 words
An article including a surface having an enhanced blood compatibility coating, wherein the coating is effected from a conjugate of anticoagulant and a water soluble protein, said protein being a non-crosslinked protein or a crosslinked protein, said conjugate having been formed by coupling a protein component and an anticoagulant with an amide bond forming agent.
Claim 3
Dependent Claim
33 words
The article according to claim 1, wherein the coating is effected from a conjugate of heparinous material and a water soluble human protein, and wherein said amide bond forming agent is 1-ethyl-3-dimethylaminopropyl carbodiimide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-07-06 | 1991-01-05 | 1991-07-07 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-07-06 | 1995-01-05 | 1995-07-07 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-07-06 | 1999-01-05 | 1999-07-07 | $7700.00 | Window Closed / Lapsed |