Patent US4668232A successfully refreshed from Google Patents.
US4668232A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Transdermal drug patches
Assignee: Schwarz GmbH
•
Filing: 1985-12-18
•
Granted: 1987-05-26
•
Expires: 2005-12-18
Abstract
Abstract The invention relates to transdermal drug patches for the controlled release of drugs to the human skin, comprising (a) an impermeable backing or covering layer, (b) a reservoir layer adjacent to, and in close contact with said backing or covering layer, said reservoir layer comprising a polymer matrix composed of a rubber and an adhesive resin material wherein said therapeutically active agent or agents are wholly or partially soluble and which is permeable to said agent or agents, (c) an adhesive layer adjacent to, and in close contact with, said reservoir layer and permeable to said therapeutically active agent or agents, and (d) a protective layer covering and adhearing to said adhesive layer and removeable therefrom for the use of said transdermal drug patch, the improvement wherein said drug or drugs in the rubber and adhesive resin material of the reservoir layer are present together with a polymer capable of swelling in water and insoluble in the rubber and adhesive resin material of the reservoir layer, the quantity of said polymer being between 3 and 30% by weight of the rubber and adhesive resin mixture. By the incorporation of this particular water-swellable polymer material in the rubber/adhesive resin mixture together with the drug which polymer material is insoluble in the matrix, in a particular proportion calculated to the weight of the rubber and adhesive resin material in particular the drug release from the patch to the skin is increased to twice or even more is achieved.
Inventors
- 👤 G/u/ nter Cordes
- 👤 Michael Wolff
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 20:06
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/70; A61K9/7023; A61K9/703; A61K9/7038; A61K9/7046; A61K9/7053; A61K9/7076; A61K9/7084; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/58; A61L15/585; A61L15/60
Claims Analysis
Total Claims: 36
Claim 1
Independent Claim
186 words
In a transdermal drug patch for the controlled release of a drug to the human skin comprising: (a) an impermeable backing or covering layer, (b) a reservoir layer adjacent to, and in close contact with, said backing or covering layer, said reservoir layer comprising a polymer matrix composed of a rubber and an adhesive resin material in which a therapeutically active drug agent is present in wholly or partially soluble form and said material being permeable to said agent or agents, (c) an adhesive layer adjacent to, and in close contact with, said reservoir layer and permeable to said therapeutically active agent, and (d) a protective layer covering and adhearing to said adhesive layer and removable therefrom for the use of said transdermal drug patch, the improvement wherein said drug agent in the rubber and adhesive resin material of the reservoir layer is present together with a polymer capable of swelling in water and insoluble in the rubber and adhesive resin material of the reservoir layer, the quantity of said polymer being between 3 and 30 percent by weight of the rubber and adhesive resin mixture.
Claim 2
Dependent Claim
186 words
In a transdermal drug patch for the controlled release of a drug to the human skin comprising: (a) an impermeable backing or covering layer, (b) a reservoir layer adjacent to, and in close contact with, said backing or covering layer, said reservoir layer comprising a polymer matrix composed of a rubber and an adhesive resin material in which a therapeutically active drug agent is present in wholly or partially soluble form and said material being permeable to said agent or agents, (c) an adhesive layer adjacent to, and in close contact with, said reservoir layer and permeable to said therapeutically active agent, and (d) a protective layer covering and adhearing to said adhesive layer and removable therefrom for the use of said transdermal drug patch, the improvement wherein said drug agent in the rubber and adhesive resin material of the reservoir layer is present together with a polymer capable of swelling in water and insoluble in the rubber and adhesive resin material of the reservoir layer, the quantity of said polymer being between 3 and 30 percent by weight of the rubber and adhesive resin mixture.
Claim 3
Dependent Claim
32 words
Transdermal drug patch according to claim 1 wherein the drug is a compound selected from the group consisting of the beta blockers, the steroid hormones, the calcium antagonists and the cardiac-acting drugs.
Claim 4
Dependent Claim
36 words
Transdermal drug patch according to claim 1 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a polysaccharide or a mixture of polysaccharides.
Claim 5
Dependent Claim
36 words
Transdermal drug patch according to claim 2 wherein the polymer capable of swelling in water and insolule in the material of the reservoir layer and/or the adhesive layer is a polysaccharide or a mixture of polysaccharides.
Claim 6
Dependent Claim
43 words
Transdermal drug patch according to claim 2 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a membrane selected from the group consisting of a galactomannane, microcrystalline cellulose and tragacanth.
Claim 7
Dependent Claim
43 words
Transdermal drug patch according to claim 3 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a membrane selected from the group consisting of a galactomannane, microcrystalline cellulose and tragacanth.
Claim 8
Dependent Claim
43 words
Transdermal drug patch according to claim 4 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a membrane selected from the group consisting of a galactomannane, microcrystalline cellulose and tragacanth.
Claim 9
Dependent Claim
33 words
Transdermal drug patch for estradiol according to claim 1 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 10
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 2 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 11
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 3 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 12
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 4 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 13
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 5 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 14
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 6 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 15
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 7 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 16
Dependent Claim
29 words
Transdermal drug patch for bupranolol according to claim 1 wherein the polymer capable of swelling in water and insoluble in the material of the adhesive film is microcrystalline cellulose.
Claim 17
Dependent Claim
29 words
Transdermal drug patch for bupranolol according to claim 2 wherein the polymer capable of swelling in water and insoluble in the material of the adhesive film is microcrystalline cellulose.
Claim 18
Dependent Claim
29 words
Transdermal drug patch for bupranolol according to claim 3 wherein the polymer capable of swelling in water and insoluble in the material of the adhesive film is microcrystalline cellulose.
Claim 19
Dependent Claim
29 words
Transdermal drug patch for bupranolol according to claim 4 wherein the polymer capable of swelling in water and insoluble in the material of the adhesive film is microcrystalline cellulose.
Claim 20
Dependent Claim
29 words
Transdermal drug patch for bupranolol according to claim 5 wherein the polymer capable of swelling in water and insoluble in the material of the adhesive film is microcrystalline cellulose.
Claim 21
Dependent Claim
29 words
Transdermal drug patch for bupranolol according to claim 6 wherein the polymer capable of swelling in water and insoluble in the material of the adhesive film is microcrystalline cellulose.
Claim 22
Dependent Claim
33 words
Transdermal drug patch for estadiol according to claim 7 wherein the polymer capable of swelling in water and insoluble in the material of the reservoir layer and/or the adhesive layer is a galactomannane.
Claim 23
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 1 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 24
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 2 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 25
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 3 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 26
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 4 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 27
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 5 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 28
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 6 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 29
Dependent Claim
33 words
Transdermal drug patch for nitroglycerin in accordance with claim 7 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film and/or adhesive film is microcrystalline cellulose.
Claim 30
Dependent Claim
30 words
Transdermal drug patch for propranolol according to claim 1 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microcrystalline cellulose.
Claim 31
Dependent Claim
30 words
Transdermal drug patch for propanolol according to claim 7 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microcrystalline cellulose.
Claim 32
Dependent Claim
30 words
Transdermal drug patch for propanolol according to claim 3 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microcrystalline cellulose.
Claim 33
Dependent Claim
30 words
Transdermal drug patch for propanolol according to claim 4 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microcrystalline cellulose.
Claim 34
Dependent Claim
30 words
Transdermal drug patch for propanolol according to claim 5 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microcrystalline cellulose.
Claim 35
Dependent Claim
30 words
Transdermal drug patch for propanolol according to claim 6 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microcrystalline cellulose.
Claim 36
Dependent Claim
30 words
Transdermal drug patch for propranolol according to claim 7 wherein the polymer capable of swelling in water and insoluble in the material of the matrix film/adhesive film is microsrystalline cellulose.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-05-25 | 1990-11-24 | 1991-05-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-05-25 | 1994-11-24 | 1995-05-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-05-25 | 1998-11-24 | 1999-05-26 | $7700.00 | Window Closed / Lapsed |