Patent US4659716A successfully refreshed from Google Patents.
US4659716A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Antihistaminic 8-(halo)-substituted 6,11-dihydro-11-(4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridines
Assignee: Merck Sharp & Dohme LLC
•
Filing: 1986-03-12
•
Granted: 1987-04-21
•
Expires: 2006-03-12
Abstract
Abstract Disclosed are 7- and/or 8-(halo or trifluoromethyl)-substituted-6,11-dihydro-11-(4-piperidylidene)-5H-ben zo[5,6]cyclohepta[1,2-b]pyridines and the pharmaceutically acceptable salts thereof, which possess antihistaminic properties with substantially no sedative properties. Methods for preparing and using the compounds and salts are described.
Inventors
- 👤 Frank J. Villani
- 👤 Jesse K. Wong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 15:06
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/81; C07D221/00; C07D221/02; C07D221/04; C07D221/06; C07D221/16
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
18 words
A compound of the formula ##STR17## or a pharmaceutically acceptable salt thereof, wherein X represents Cl or F.
Claim 2
Dependent Claim
18 words
A compound of the formula ##STR17## or a pharmaceutically acceptable salt thereof, wherein X represents Cl or F.
Claim 3
Dependent Claim
14 words
A compound defined in claim 1 in the form of the acetic acid salt.
Claim 4
Dependent Claim
13 words
A compound having the structural formula ##STR18## or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
13 words
A compound having the structural formula ##STR18## or a pharmaceutically acceptable salt thereof.
Claim 6
Dependent Claim
13 words
A compound having the structural formula ##STR19## or a pharmaceutically acceptable salt thereof.
Claim 7
Dependent Claim
13 words
A compound having the structural formula ##STR19## or a pharmaceutically acceptable salt thereof.
Claim 8
Dependent Claim
25 words
An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of a compound as defined in claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 9
Dependent Claim
24 words
An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of the compound defined in claim 2 in combination with a pharmaceutically acceptable carrier.
Claim 10
Dependent Claim
24 words
An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of the compound defined in claim 3 in combination with a pharamaceutically acceptable carrier.
Claim 11
Dependent Claim
24 words
An antihistaminic pharmaceutical composition which comprises an antihistaminic effective amount of the compound defined in claim 4 in combination with a pharmaceutically acceptable carrier.
Claim 12
Dependent Claim
11 words
A composition as defined in claim 7 in unit dosage form.
Claim 13
Dependent Claim
11 words
A composition as defined in claim 8 in unit dosage form.
Claim 14
Dependent Claim
24 words
A transdermally acceptable pharmaceutical composition comprising an anti-allergic effective amount of a compound as defined in claim 1 and a pharamaceutically acceptable transdermal carrier.
Claim 15
Dependent Claim
24 words
A transdermally acceptable pharamaceutical composition comprising a anti-allergic effective amount of a compound as defined in claim 3 and a pharmaceutically acceptable transdermal carrier.
Claim 16
Dependent Claim
24 words
A transdermally acceptable pharmaceutical composition comprising an anti-allergic effective amount of a compound as defined in claim 4 and a pharmaceutically acceptable transdermal carrier.
Claim 17
Dependent Claim
27 words
A method for treating allergic reactions in a mammal which comprises administering to said mammal an anti-allergic effective amount of a compound as defined in claim 1.
Claim 18
Dependent Claim
27 words
A method of treating allergic reactions in a mammal which comprises administering to said mammal an anti-allergic effective amount of a compound as defined in claim 3.
Claim 19
Dependent Claim
27 words
A method for treating allergic reactions in a mammal which comprises administering to said mammal an anti-allergic effective amount of a compound as defined in claim 4.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-04-20 | 1990-10-20 | 1991-04-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-04-20 | 1994-10-20 | 1995-04-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-04-20 | 1998-10-20 | 1999-04-21 | $7700.00 | Window Closed / Lapsed |