US4657928A
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Organic copper complexes as radioprotectants
Assignee: INTERNATIONAL COPPER RESEARCH ASSOCIATION Inc A NY CORP
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Filing: 1984-09-25
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Granted: 1987-04-14
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Expires: 2004-09-25
Abstract
Abstract Methods are described for using organic copper complexes or their solvates, which exhibit superoxide dismutase activity and act as superoxide radical scavengers, as radioprotectants to protect mammalian cells from damage caused by gamma- or x-irradiation. Treatment can result in the protection of normal tissues in cancer patients undergoing radiotherapy and in the protection of individuals who may be at risk with regard to hazardous effects of exposure to occupational or environmental ionizing radiation.
Inventors
- 👤 John R. J. Sorenson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 14:09
CPC Classifications
C; C07; C07F; C07F1/00; C07F1/005
Claims Analysis
Total Claims: 39
Claim 1
Independent Claim
47 words
A method of providing radioprotection, comprising: administering a radioprotective amount of an organic copper complex, or a solvate thereof, having superoxide dismutase activity to a human being or animal within about two weeks of exposing said human being or animal to therapeutic doses of gamma-rays or X-rays.
Claim 2
Independent Claim
47 words
A method of providing radioprotection, comprising: administering a radioprotective amount of an organic copper complex, or a solvate thereof, having superoxide dismutase activity to a human being or animal within about two weeks of exposing said human being or animal to therapeutic doses of gamma-rays or X-rays.
Claim 3
Independent Claim
40 words
A method of providing radioprotection, comprising: periodically administering a radioprotective amount of an organic copper complex, or a solvate thereof, having superoxide dismutase activity to a human being to protect against recurrent occupational or environmental exposure to gamma-rays or X-rays.
Claim 4
Independent Claim
40 words
A method of providing radioprotection, comprising: periodically administering a radioprotective amount of an organic copper complex, or a solvate thereof, having superoxide dismutase activity to a human being to protect against recurrent occupational or environmental exposure to gamma-rays or X-rays.
Claim 5
Dependent Claim
25 words
The method according to claim 1 or 2, wherein the copper complex, or a solvate thereof, is a copper salicylate complex, or a solvate thereof.
Claim 6
Dependent Claim
17 words
The method according to claim 1 or 2, wherein the copper salicylate complex is copper(II)(3,5-diisopropylsalicylate) 2 .
Claim 7
Dependent Claim
17 words
The method according to claim 1 or 2, wherein the copper salicylate complex is copper(II)(salicylate) 2 .
Claim 8
Dependent Claim
17 words
The method according to claim 1 or 2, wherein the copper salicylate complex is copper(II)(3,5-ditertiarybutylsalicylate) 2 .
Claim 9
Dependent Claim
17 words
The method according to claim 1 or 2, wherein the copper complex is a copper acetylsalicylate complex.
Claim 10
Dependent Claim
18 words
The method according to claim 1 or 2, wherein the copper complex is copper(II) 2 (acetylsalicylate) 2 .
Claim 11
Dependent Claim
21 words
The method according to claim 1 or 2, wherein the copper complex solvate is copper(II) 2 (acetylsalicylate) 4 (dimethylsulfoxide) 4 .
Claim 12
Dependent Claim
21 words
The method according to claim 1 or 2, wherein the copper complex solvate is copper(II) 2 (acetylsalicylate) 4 (pyridine) 4 .
Claim 13
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(cystinate).
Claim 14
Dependent Claim
15 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(cystinate H).
Claim 15
Dependent Claim
16 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate) 2 .
Claim 16
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(threoninate).
Claim 17
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(valinate).
Claim 18
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(lysinate).
Claim 19
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(alaninate).
Claim 20
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(serinate).
Claim 21
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(phenylalaninate).
Claim 22
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(histidinate)(glycinate).
Claim 23
Dependent Claim
18 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I) n (cysteinate) n polymeric.
Claim 24
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I)(2-aminoethylthiolate).
Claim 25
Dependent Claim
16 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(cystamine) 2 ++.
Claim 26
Dependent Claim
16 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II)(aminoethylisothiourea) 2 .
Claim 27
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I)(2-guanidinoethylthiolate).
Claim 28
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I).
Claim 29
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(II).
Claim 30
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I)(isothiourea).
Claim 31
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I)(uracilthiolate).
Claim 32
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I)(isothiocarbamate).
Claim 33
Dependent Claim
14 words
The method according to claim 1 or 2, wherein the copper complex is Cu(I)(thioamidoisothiamide).
Claim 34
Dependent Claim
24 words
The method according to claim 1, wherein the copper complex, or solvate thereof, is administered before exposure to large doses of gamma-rays or X-rays.
Claim 35
Dependent Claim
24 words
The method according to claim 1, wherein the copper complex, or solvate thereof, is administered after exposure to large doses of gamma-rays or X-rays.
Claim 36
Dependent Claim
18 words
The method according to claim 1 or 2, wherein the copper complex, or solvate thereof, is administered subcutaneously.
Claim 37
Dependent Claim
18 words
The method according to claim 1 or 2, wherein the copper complex, or solvate thereof, is administered intravenously.
Claim 38
Dependent Claim
18 words
The method according to claim 1 or 2, wherein the copper complex, or solvate thereof, is administered orally.
Claim 39
Dependent Claim
16 words
The method according to claim 2, wherein the copper complex, or solvate thereof, is administered daily.
References Cited (Backward Citations)
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