US4287190A
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US
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Complexes of bivalent copper
Assignee: Alcusal Inc Pty Ltd
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Filing: 1979-11-29
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Granted: 1981-09-01
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Expires: 1999-11-29
Abstract
Abstract Compositions containing neural copper complexes, particularly copper-salicylate complexes having the formula Cu[C 6 H 4 (X)COO] 2 . Y in which Y represents dimethylsulfoxide, dimethylformamide or an alkanol and in which X is preferably --OH, together with a pharmaceutically acceptable, non-aqueous carrier have been found to have therapeutic activity in the treatment of inflammatory diseases. The compositions have been found particularly suitable for the treatment of arthritis.
Inventors
- 👤 Barry Boettcher
- 👤 William R. Walker
- 👤 Michael W. Whitehouse
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 06:44
CPC Classifications
C; C07; C07F; C07F1/00; C07F1/005; C07C; C07C323/00; C07C323/50; C07C323/62; C07C391/00; C07C391/02
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
57 words
A topical anti-inflammatory therapeutic composition comprising an anti-inflammatory effective amount of a neutral copper complex of the formula Cu[C 6 H 4 (X)COO] 2 Y wherein Y represents dimethylsulfoxide, dimethylformamide or an alkanol, and wherein X can be located in any position and is OH, SH, SeH, NH 2 or ##STR6## and a pharmaceutically acceptable non-aqueous carrier.
Claim 2
Dependent Claim
57 words
A topical anti-inflammatory therapeutic composition comprising an anti-inflammatory effective amount of a neutral copper complex of the formula Cu[C 6 H 4 (X)COO] 2 Y wherein Y represents dimethylsulfoxide, dimethylformamide or an alkanol, and wherein X can be located in any position and is OH, SH, SeH, NH 2 or ##STR6## and a pharmaceutically acceptable non-aqueous carrier.
Claim 3
Dependent Claim
46 words
A composition according to claim 1, where said pharmaceutically acceptable non-aqueous carrier comprises an emollient and a molar excess with respect to said neutral copper complex of at least one compound selected from the group consisting of salicylic acid, C 6 H 4 (X)COOH and Y.
Claim 4
Dependent Claim
11 words
A composition according to claim 2, wherein the emollient is glycerol.
Claim 5
Dependent Claim
13 words
A composition according to claim 2 wherein the composition also contains a buffer.
Claim 6
Dependent Claim
12 words
A composition according to claim 4 wherein the buffer is sodium acetate.
Claim 7
Dependent Claim
17 words
A composition according to claim 2 wherein Y is a C 1 to C 6 aliphatic alkanol.
Claim 8
Dependent Claim
13 words
A composition according to claim 2 wherein the complex has the formula ##STR7##
Claim 9
Dependent Claim
10 words
A composition according to claim 7 wherein X is OH.
Claim 10
Dependent Claim
10 words
A composition according to claim 7 having the formula ##STR8##
Claim 11
Dependent Claim
37 words
A non-aqueous neutral copper complex of the formula Cu[C 6 H 4 (X)COO] 2 Y wherein Y represents dimethylsulfoxide, and wherein X can be located in any position and is OH, SH, SeH, NH 2 or ##STR9##
Claim 12
Dependent Claim
37 words
A non-aqueous neutral copper complex of the formula Cu[C 6 H 4 (X)COO] 2 Y wherein Y represents dimethylsulfoxide, and wherein X can be located in any position and is OH, SH, SeH, NH 2 or ##STR9##
Claim 13
Dependent Claim
9 words
The complex of claim 10, having the formula ##STR10##
Claim 14
Dependent Claim
9 words
The complex of claim 11 wherein X is OH.
Claim 15
Dependent Claim
9 words
The complex of claim 12 of the formula ##STR11##
Claim 16
Dependent Claim
32 words
A method of preparing the complex according to claim 10, comprising reacting copper (II) hydroxide with a substituted benzoic acid in the presence of dimethyl sulfoxide, or an alkanol under anhydrous conditions.
Claim 17
Dependent Claim
14 words
A method according to claim 14 wherein the substituted benzoic acid is salicylic acid.
Claim 18
Dependent Claim
18 words
A method according to claim 14 wherein the alkanol is a C 1 to C 6 aliphatic alkanol.
Claim 19
Dependent Claim
15 words
A composition according to claim 1 containing 0.1 to 15% w/v of said copper complex.
Claim 20
Dependent Claim
23 words
A method of treating inflammatory diseases comprising topically administering to a patient an anti-inflammatory effective amount of a composition according to claim 1.
Claim 21
Dependent Claim
10 words
The copper complex of claim 13 where Y is dimethylsulfoxide.
References Cited (Backward Citations)
US4020180A
Cited
US3884949A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-08-31 | 1985-03-02 | 1985-09-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-08-31 | 1989-03-02 | 1989-09-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-08-31 | 1993-03-02 | 1993-09-01 | $7700.00 | Window Closed / Lapsed |