US4654337A
Expired / Lapsed
US
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Perfluoro-1-azatricyclic amine compounds useful as blood substitutes or in infusion fluids
Assignee: Tanabe Pharma Corp
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Filing: 1985-07-05
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Granted: 1987-03-31
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Expires: 2005-07-05
Abstract
Abstract A novel compound of the formula, ##STR1## wherein k is zero or an integer of 1 to 2, j is an integer of from 1 or 3, l and m are each zero or an integer of from 1 to 3, and n is an integer of from 1 to 4, the rings A, B and C being optionally substituted with at least one trifluoromethyl group or tetrafluoroethyl group is prepared by reacting the perhydro compound corresponding thereto with fluorine. The compound is useful as a material capable of carrying oxygen in an aqueous emulsion for lifesaving a patient suffering from massive hemorrhage and for preserving internal organs in transplantation.
Inventors
- 👤 Kazumasa Yokoyama
- 👤 Chikara Fukaya
- 👤 Yoshio Tsuda
- 👤 Taizo Ono
- 👤 Yoshio Arakawa
- 👤 Yoshihisa Inoue
- 👤 Youichiro Naito
- 👤 Tadakazu Suyama
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:28
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K9/0026; C; C07; C07D; C07D453/00; C07D453/02; C07D471/00; C07D471/02; C07D471/08; C07D487/00; C07D487/02; C07D487/08; C25; C25B; C25B3/00; C25B3/01; C25B3/05; C25B3/09; C25B3/11; C25B3/20; C25B3/27; C25B3/28
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
61 words
A perfluoro-1-azatricyclic amine compound represented by the formula: ##STR115## wherein j, k, l and m ae each an integer of from zero to 3 so as to make one of the rings A and B to be 6 membered and the other 7 or more membered; n is zero, or 1; any one fluorine being optionally replaced by one trifluoromethyl group.
Claim 2
Dependent Claim
61 words
A perfluoro-1-azatricyclic amine compound represented by the formula: ##STR115## wherein j, k, l and m ae each an integer of from zero to 3 so as to make one of the rings A and B to be 6 membered and the other 7 or more membered; n is zero, or 1; any one fluorine being optionally replaced by one trifluoromethyl group.
Claim 3
Dependent Claim
21 words
A perfluoro-1-azatricyclic amine compound according to claim 1, wherein j is 1, k is 0, and l and m is 2.
Claim 4
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 2 which is 1-azatricyclo[7,3,1,0 2 ,6 ]tridecane.
Claim 5
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 2 which is 1-azatricyclo[7,3,1,0 3 ,7 ]tridecane.
Claim 6
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 2, which is 1-azatricyclo[7,3,1,0 4 ,8] tridecane.
Claim 7
Dependent Claim
23 words
A perfluoro-1-azatricyclic amine compound according to claim 1, wherein j is zero, k is 1, and l plus m is 1 or 2.
Claim 8
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 6, which is 1-azatricyclo[6,2,2,0 2 ,6 ]dodecane.
Claim 9
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 6, which is 1-azatricyclo[6,2,2,0 2 ,7 ]dodecane.
Claim 10
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 6, which is 1-azatricyclo[7,2,2,0 2 ,6 ]tridecane.
Claim 11
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 6, which is 1-azatricyclo[7,2,2,0 2 ,7 ]tridecane.
Claim 12
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 6, which is 1-azatricyclo[7,2,2,0 3 ,7 ]tridecane.
Claim 13
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 6, which is 1-azatricyclo[7,2,2,0 3 ,8 ]tridecane.
Claim 14
Dependent Claim
14 words
A perfluoro-1-azatricyclic amine compound according to claim 6, which is 1-azatricyclo[7,2,2,0 4 ,8 ]tridecane.
Claim 15
Dependent Claim
21 words
A perfluoro-1-azatricyclic amine compound according to claim 1, wherein j is 2, k is zero, and l plus m is 1.
Claim 16
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 14, which is 1-azatricyclo[6,4,1,0 2 ,6 ]tridecane.
Claim 17
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 14, which is 1-azatricyclo[6,4,1,0 3 ,7 ]tridecane.
Claim 18
Dependent Claim
22 words
A perfluoro-1-azatricyclic amine compound according to claim 1, wherein j and k are each 1, and l and m are each zero.
Claim 19
Dependent Claim
13 words
A perfluoro-1-azatricyclic amine compound of claim 17, which is 1-azatricyclo6,3,2,0 2 ,7 ]tridecane.
Claim 20
Dependent Claim
29 words
A composition for use as a blood substitute or infusion fluid which composition is an aqueous emulsion of a compound of the formula given and defined in claim 1.
Claim 21
Dependent Claim
25 words
A compostion according to claim 19, which contains from 5 to 50% (W/V) of the compound of the formula given and defined in claim 11.
Claim 22
Dependent Claim
15 words
A composition according to claim 19, which contains, as emulsifier, a nonionic surfactant and/or phospholipid.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-30 | 1990-09-29 | 1991-03-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-30 | 1994-09-29 | 1995-03-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-30 | 1998-09-29 | 1999-03-31 | $7700.00 | Window Closed / Lapsed |