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US4562183A
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Perfluoro-1-azabicyclo(5,3,0)decane compounds useful as blood substitutes
Assignee: IS C CHEMICALS Ltd A BRITISH Co
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Filing: 1983-01-24
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Granted: 1985-12-31
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Expires: 2003-01-24
Abstract
Abstract Novel perfluorinated heterocyclic compounds have an azabicyclodecane structure with fused 5- and 7-membered rings incorporating a bridgehead nitrogen atom. They are prepared by cobalt (III) fluoride fluorination of quinolines or alkyl quinolines and are useful, when emulsified in aqueous media, as blood substitutes or organ perfusates, prior to transplant.
Inventors
- 👤 John C. Tatlow
- 👤 Raymond G. Plevey
- 👤 David E. M. Wotton
- 👤 Colin R. Sargent
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 01:16
CPC Classifications
C; C07; C07D; C07D487/00; C07D487/02; C07D487/04; A; A61; A61P; A61P7/00; A61P7/08
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
36 words
A perfluoroazabicyclodecane compound having a bridgehead nitrogen in its structure wherein said compound is selected from the group consisting of perfluoro-1-azabicyclo(5,3,0)decane, which has fused 5- and 7-membered rings, and its perfluoroalkyl homologues of 1-2 carbon atoms.
Claim 2
Dependent Claim
36 words
A perfluoroazabicyclodecane compound having a bridgehead nitrogen in its structure wherein said compound is selected from the group consisting of perfluoro-1-azabicyclo(5,3,0)decane, which has fused 5- and 7-membered rings, and its perfluoroalkyl homologues of 1-2 carbon atoms.
Claim 3
Dependent Claim
25 words
A compound according to claim 1, which has a trifluoromethyl group attached to a carbon atom adjacent to a bridgehead nitrogen atom of its structure.
Claim 4
Dependent Claim
60 words
An oil-in-water emulsion useful as a blood substitute comprising a perfluoroazabicyclodecane compound having a bridgehead nitrogen in its structure when said compound is dispersed in an aqueous phase by a surface active agent wherein said compound is selected from the group consisting of perfluoro-1-azabicyclo(5,3,0)decane, which has fused 5- and 7-membered rings, and its perfluoro alkyl homologues of 1-2 carbon atoms.
Claim 5
Dependent Claim
60 words
An oil-in-water emulsion useful as a blood substitute comprising a perfluoroazabicyclodecane compound having a bridgehead nitrogen in its structure when said compound is dispersed in an aqueous phase by a surface active agent wherein said compound is selected from the group consisting of perfluoro-1-azabicyclo(5,3,0)decane, which has fused 5- and 7-membered rings, and its perfluoro alkyl homologues of 1-2 carbon atoms.
Claim 6
Dependent Claim
16 words
The emulsion according to claim 3, in which the surface active agent is non-ionic in character.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-30 | 1989-07-01 | 1989-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-30 | 1993-07-01 | 1993-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-30 | 1997-07-01 | 1997-12-31 | $7700.00 | Window Closed / Lapsed |