Abstract The invention involves the use of absorbable or absorbable/nonabsorbable components to fabricate textile vascular grafts of all sizes and specifically for repair of the peripheral vascular system and for coronary bypass use. The bioabsorbable component of the graft fosters increased tissue ingrowth into the graft as compared to conventional 100% nonabsorbable grafts. Increased tissue ingrowth leads to greater patency through formation of a vascularized neointima and less tendency to be aneurysmal through formation of a suitable adventitia. The absorbable component can be a variety of materials, including PGA, MAXON™, etc., whereas the nonabsorbable component (to be used as the backbone) can be new materials, e.g. NOVAFIL®, or more conventional polymers, including polyester, polyamide or polypropylene.
A knitted vascular graft having a plurality of at least three different fibers, the first and second fibers manufactured from two different absorbable polymers, one of said polymers comprising up to about fifty percent by weight of trimethylene carbonate linkages, and the third fiber manufactured from a nonabsorbable polymer.
Claim 2
Dependent Claim
49 words
A knitted vascular graft having a plurality of at least three different fibers, the first and second fibers manufactured from two different absorbable polymers, one of said polymers comprising up to about fifty percent by weight of trimethylene carbonate linkages, and the third fiber manufactured from a nonabsorbable polymer.
Claim 3
Dependent Claim
67 words
A vascular graft having at least three different components, said first, second and third components manufactured respectively from three different fibers, the first and second fibers manufactured from two different absorbable polymers, one of said polymers comprising up to about fifty percent by weight of trimethylene carbonate linkages, and the third fiber manufactured from a nonabsorbable polymer, said components knitted or woven together in a concentric relationship.
Claim 4
Dependent Claim
67 words
A vascular graft having at least three different components, said first, second and third components manufactured respectively from three different fibers, the first and second fibers manufactured from two different absorbable polymers, one of said polymers comprising up to about fifty percent by weight of trimethylene carbonate linkages, and the third fiber manufactured from a nonabsorbable polymer, said components knitted or woven together in a concentric relationship.