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US4650678A
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Readily dissolvable lyophilized fibrinogen formulation
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1984-08-10
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Granted: 1987-03-17
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Expires: 2004-08-10
Abstract
Abstract A solid fibrinogen formulation is described, which formulation contains, in addition to fibrinogen, a substance containing the urea or guanidine radical, and a process for its preparation. This formulation is used for the preparation of a fibrinogen solution which is suitable as an adhesive for human and animal tissue and as a fibrinogen concentrate for intravenous administration.
Inventors
- 👤 Peter Fuhge
- 👤 Norbert Heimburger
- 👤 Hans-Arnold Stohr
- 👤 Wolfgang Burk
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 23:23
CPC Classifications
A; A61; A61L; A61L24/00; A61L24/04; A61L24/10; A61L24/106; C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/75; A61K; A61K38/00
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
55 words
A lyophilized fibrinogen formulation consisting essentially of fibrinogen and from 0.05 to 5 percent by weight of a substance selected from the group consisting of arginine, creatine, creatinine, glycocyamine, urea and citrulline, said substance enabling the fibrinogen to be readily dissolved in an aqueous solution to a concentration of 2 to 14 percent by weight.
Claim 2
Dependent Claim
55 words
A lyophilized fibrinogen formulation consisting essentially of fibrinogen and from 0.05 to 5 percent by weight of a substance selected from the group consisting of arginine, creatine, creatinine, glycocyamine, urea and citrulline, said substance enabling the fibrinogen to be readily dissolved in an aqueous solution to a concentration of 2 to 14 percent by weight.
Claim 3
Dependent Claim
33 words
A formulation as claimed in claim 1 which further comprises at least 0.1 to 5 percent by weight of either an amino acid having a hydrophobic side chain or a water-soluble fatty acid.
Claim 4
Dependent Claim
12 words
The lyophilized formulation of claim 1 consisting essentially of fibrinogen and arginine.
Claim 5
Dependent Claim
33 words
A formulation as claimed in claim 3 which further comprises at least 0.1 to 5 percent by weight of either an amino acid having a hydrophobic side chain or a water-soluble fatty acid.
Claim 6
Dependent Claim
19 words
A formulation as claimed in one of claims 2, 3 or 4 which further comprises factor XIII and aprotinin.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1990-03-16 | 1990-09-15 | 1991-03-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1994-03-16 | 1994-09-15 | 1995-03-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1998-03-16 | 1998-09-15 | 1999-03-17 | $7700.00 | Window Closed / Lapsed |