Patent US4627919A successfully refreshed from Google Patents.
US4627919A
Expired / Lapsed
US
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Resolving agent
Assignee: Daicel Corp
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Filing: 1986-01-21
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Granted: 1986-12-09
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Expires: 2006-01-21
Abstract
Abstract A racemic mixture can be optically resolved by liquid chromatography, using a packing of the compound: <IMAGE> (I) wherein at least one group selected from among Y1, Y2 and Y3 represents silica gel and/or a siloxane bond moiety therewith and others represent each a hydrogen atom, an alkyl group having one to 20 carbon atoms, an aryl group having six to 20 carbon atoms, an arylalkyl group having seven to 20 carbon atoms, a halogen atom, a hydroxyl group, an alkoxy group having one to 20 carbon atoms or a combination thereof; X represents a spacer having one to 20 carbon atoms; and R represents a metallic slat of optically active t-leucine or tryptophane.
Inventors
- 👤 Yoichi Yuki
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 19:14
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/30; B01J20/32; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3257; B01J20/3263; B01D; B01D15/00; B01D15/08; B01D15/26; B01D15/38; B01D15/3833; B01J20/281; B01J20/286; B01J20/289; B01J20/29; B01J20/3259; B01J20/3265
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
117 words
A method for the optical resolution of a racemic mixture with a compound having the formula: ##STR14## wherein at least one group selected from among Y 1 , Y 2 and Y 3 represents silica gel and/or a siloxane bond moiety therewith while others represent each a hydrogen atom, an alkyl group having one to 20 carbon atoms, an aryl group having six to 20 carbon atoms, an arylalkyl group having seven to 20 carbon atoms, a halogen atom, a hydroxyl group, an alkoxy group having one to 20 carbon atoms or a combination thereof; X represents a spacer having one to 30 carbon atoms; and R is a metal salt of optically active t-leucine or tryptophane.
Claim 2
Independent Claim
117 words
A method for the optical resolution of a racemic mixture with a compound having the formula: ##STR14## wherein at least one group selected from among Y 1 , Y 2 and Y 3 represents silica gel and/or a siloxane bond moiety therewith while others represent each a hydrogen atom, an alkyl group having one to 20 carbon atoms, an aryl group having six to 20 carbon atoms, an arylalkyl group having seven to 20 carbon atoms, a halogen atom, a hydroxyl group, an alkoxy group having one to 20 carbon atoms or a combination thereof; X represents a spacer having one to 30 carbon atoms; and R is a metal salt of optically active t-leucine or tryptophane.
Claim 3
Dependent Claim
16 words
A method as claimed in claim 1, in which R is a metal salt of tryptophane.
Claim 4
Dependent Claim
16 words
A method as claimed in claim 1, in which R is a metal salt of t-leucine.
Claim 5
Dependent Claim
18 words
A method as claimed in claim 1, in which said resolution is carried out by the liquid chromatography.
Claim 6
Dependent Claim
21 words
A method as claimed in claim 1, in which said metal is selected from copper, nickel, zinc, cadmium, mercury and cobalt.
Claim 7
Dependent Claim
119 words
A separation agent for the optical resolution of a racemic mixture which comprises a compound having the formula: ##STR15## wherein at least one group selected from among Y 1 , Y 2 and Y 3 represents silica gel and/or a siloxane bond moiety therewith while others represent each a hydrogen atom, an alkyl group having one to 20 carbon atoms, an aryl group having six to 20 carbon atoms, an arylalkyl group having seven to 20 carbon atoms, a halogen atom, a hydroxyl group, an alkoxy group having one to 20 carbon atoms or a combination thereof; X represents a spacer having one to 30 carbon atoms; and R is a metal salt of optically active t-leucine or tryptophane.
Claim 8
Dependent Claim
119 words
A separation agent for the optical resolution of a racemic mixture which comprises a compound having the formula: ##STR15## wherein at least one group selected from among Y 1 , Y 2 and Y 3 represents silica gel and/or a siloxane bond moiety therewith while others represent each a hydrogen atom, an alkyl group having one to 20 carbon atoms, an aryl group having six to 20 carbon atoms, an arylalkyl group having seven to 20 carbon atoms, a halogen atom, a hydroxyl group, an alkoxy group having one to 20 carbon atoms or a combination thereof; X represents a spacer having one to 30 carbon atoms; and R is a metal salt of optically active t-leucine or tryptophane.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-12-08 | 1990-06-09 | 1990-12-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-12-08 | 1994-06-09 | 1994-12-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-12-08 | 1998-06-09 | 1998-12-09 | $7700.00 | Window Closed / Lapsed |