US4565877A
Expired / Lapsed
US
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Naphthalene derivatives and method for preparation thereof
Assignee: Tanabe Pharma Corp
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Filing: 1983-10-11
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Granted: 1986-01-21
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Expires: 2003-10-11
Abstract
Abstract A naphthalene derivative of the formula: ##STR1## wherein R 1 is hydrogen and R 2 is lower alkyl or phenyl-lower alkyl; or R 1 and R 2 are combined together to form lower alkylene; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration, and a method of preparation thereof are disclosed. Said naphthalene derivative is useful as a chiral reagent for determining the optical purity of an optically active compound containing within its molecule at least one functional group selected from hydroxy, amino and imino groups.
Inventors
- 👤 Hiroshi Wada
- 👤 Kazuhiro Ishii
- 👤 Nobuchika Tsumagari
- 👤 Masaaki Matsuo
- 👤 Mikio Matsumoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 16:52
CPC Classifications
C; C07; C07D; C07D217/00; C07D217/12; C07D217/18; C07D217/20; C07C; C07C311/00; C07C311/15; C07D207/00; C07D207/46; C07D207/48; C07D281/00; C07D281/02; C07D281/04; C07D281/08; C07D281/10; Y; Y10; Y10T; Y10T436/00; Y10T436/25
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
58 words
An optically active naphthalene derivative of the formula: ##STR5## wherein R 1 is hydrogen and R 2 is lower alkyl or phenyl-lower alkyl; or R 1 and R 2 are combined together to form alkylene of 2-4carbons; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration.
Claim 2
Dependent Claim
58 words
An optically active naphthalene derivative of the formula: ##STR5## wherein R 1 is hydrogen and R 2 is lower alkyl or phenyl-lower alkyl; or R 1 and R 2 are combined together to form alkylene of 2-4carbons; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration.
Claim 3
Dependent Claim
45 words
The naphthalene derivative claimed in claim 1, in which R 1 is hydrogen and R 2 is alkyl of one to 4 carbon atoms, benzyl or phenethyl; or R 1 and R 2 are combined together to form alkylene of 2 to 4 carbon atoms.
Claim 4
Dependent Claim
32 words
The naphthalene derivative claimed in claim 1, in which R 1 is hydrogen and R 2 is methyl or benzyl; or R 1 and R 2 are combined together to form trimethylene.
Claim 5
Dependent Claim
15 words
The naphthalene derivative claimed in claim 2 in which X is chlorine or fluorine atom.
Claim 6
Dependent Claim
15 words
The naphtalene derivative claimed in claim 3, in which X is chlorine or fluorine atom.
Claim 7
Dependent Claim
75 words
An optically active naphthalene derivative of the formula: ##STR6## wherein R 1 is hydrogen and R 2 is alkyl of one to 5 carbon atoms or phenyl-lower alkyl, said alkyl having one to three carbon atoms; X is halogen; or R 1 and R 2 are combined to form alkylene of 2-4 carbon atoms; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration.
Claim 8
Dependent Claim
75 words
An optically active naphthalene derivative of the formula: ##STR6## wherein R 1 is hydrogen and R 2 is alkyl of one to 5 carbon atoms or phenyl-lower alkyl, said alkyl having one to three carbon atoms; X is halogen; or R 1 and R 2 are combined to form alkylene of 2-4 carbon atoms; X is halogen; and the absolute configuration at the asymmetric carbon atom shown by the asterisk is either (S)- or (R)-configuration.
References Cited (Backward Citations)
US3424749A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-20 | 1989-07-22 | 1990-01-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-20 | 1993-07-22 | 1994-01-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-20 | 1997-07-22 | 1998-01-21 | $7700.00 | Window Closed / Lapsed |