US4610986A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Aminonaphthacene derivatives and their production
Assignee: Sumitomo Chemical Co Ltd
•
Filing: 1984-10-12
•
Granted: 1986-09-09
•
Expires: 2004-10-12
Abstract
Abstract A (7S,9S) isomer or its racemic modification of the aminonaphthacene derivative of the formula: <IMAGE> wherein R1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R2 is a hydrogen atom or a hydroxyl group, R3 and R4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, A is an ethylene group optionally bearing at least one lower alkyl and Q is a hydroxyl group, a lower alkoxy group or a dimethylamino group, or an acid addition salt thereof, which is useful as an anti-tumor agent.
Inventors
- 👤 Kikuo Ishizumi
- 👤 Michihisa Muramatsu
- 👤 Norihiko Tanno
- 👤 Hiromi Sato
- 👤 Noboru Yoshida
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 06:06
CPC Classifications
C; C07; C07D; C07D317/00; C07D317/08; C07D317/10; C07D317/14; C07D317/28
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
95 words
A (7S,9S) isomer or its racemic modification of the aminonaphthacene derivative of the formula: ##STR8## wherein R 1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R 2 is a hydrogen atom or a hydroxyl group, R 3 and R 4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, A is an ethylene group optionally bearing at least one lower alkyl and Q is a hydroxyl group, a lower alkoxy group or a dimethylamino group, or an acid addition salt thereof.
Claim 2
Dependent Claim
95 words
A (7S,9S) isomer or its racemic modification of the aminonaphthacene derivative of the formula: ##STR8## wherein R 1 is a hydrogen atom, a hydroxyl group or a lower alkoxy group, R 2 is a hydrogen atom or a hydroxyl group, R 3 and R 4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group or an oxo group, A is an ethylene group optionally bearing at least one lower alkyl and Q is a hydroxyl group, a lower alkoxy group or a dimethylamino group, or an acid addition salt thereof.
Claim 3
Dependent Claim
31 words
The (7S,9S) isomer or its racemic modification according to claim 1, wherein R 3 and R 4 are each a lower alkoxy group or, when taken together, represent an ethylenedioxy group.
Claim 4
Dependent Claim
25 words
The (7S,9S) isomer or its racemic modification according to claim 1, wherein R 3 and R 4 are taken together to represent an oxo group.
Claim 5
Dependent Claim
25 words
The (7S,9S) isomer or its racemic modification according to claim 3, wherein R 1 is a hydrogen atom and R 2 is a hydroxyl group.
Claim 6
Dependent Claim
22 words
The (7S,9S) isomer or its racemic modification according to claim 3, wherein R 1 and R 2 are each a hydroxyl group.
Claim 7
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-dimethylaminoethyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 8
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-dimethylaminoethyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 9
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-hydroxyethyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 10
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-hydroxyethyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 11
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-methoxyethyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 12
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-methoxyethyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 13
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-hydroxypropyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 14
Dependent Claim
9 words
A (7S,9S) isomer or its racemic modification of 7-(2-hydroxypropyl)amino-9-acetyl-6,9,11-trihydroxy-5,7,8,9,10,12-hexahydronaphthacene-5,12-dione.
Claim 15
Dependent Claim
31 words
An anti-tumor composition in the form of a solid or liquid pharmaceutical preparation, said composition containing an effective anti-tumor amount of a compound according to claim 1 as an active ingredient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-08 | 1990-03-10 | 1990-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-08 | 1994-03-10 | 1994-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-08 | 1998-03-10 | 1998-09-09 | $7700.00 | Window Closed / Lapsed |