US4610872A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation
Assignee: Zeneca Inc
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Filing: 1985-12-27
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Granted: 1986-09-09
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Expires: 2005-12-27
Abstract
Abstract Dentifrice formulations containing monoalkyl and dialkyl ethers of dianhydrohexitols in the form of toothpaste, mouthwash, chewing gums, confections, toothpicks and dental floss are effective in the treatment of oral surfaces and cavities to reduce irritation and plaque accumulation caused by the action of bacteria.
Inventors
- 👤 Matthew J. Lynch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:47
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4973
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
121 words
In a mouthwash or gargle formulation for inhibiting the formation of plaque and calculus and relieving throat irritation in the oral cavity of mammals which comprises at least two ingredients selected from the group consisting of water, stabilizers, coloring agents, flavoring agents, surfactants, astringents, detergents, medicaments, sweeteners and antibacterial agents, the improvement which consists essentially of including therewith and S. mutans inhibiting amount of a dianhydrohexitol compound having the general formula: ##STR2## wherein R' and R" are individually selected from alkyl radicals selected from the group consisting of --CH 3 , --C 2 H 5 , --C 3 H 7 , --C 4 H 9 or --H when the other R' or R" is an alkyl radical of 1-4 carbon atoms.
Claim 2
Dependent Claim
121 words
In a mouthwash or gargle formulation for inhibiting the formation of plaque and calculus and relieving throat irritation in the oral cavity of mammals which comprises at least two ingredients selected from the group consisting of water, stabilizers, coloring agents, flavoring agents, surfactants, astringents, detergents, medicaments, sweeteners and antibacterial agents, the improvement which consists essentially of including therewith and S. mutans inhibiting amount of a dianhydrohexitol compound having the general formula: ##STR2## wherein R' and R" are individually selected from alkyl radicals selected from the group consisting of --CH 3 , --C 2 H 5 , --C 3 H 7 , --C 4 H 9 or --H when the other R' or R" is an alkyl radical of 1-4 carbon atoms.
Claim 3
Dependent Claim
13 words
A composition of claim 1 containing from 5-90% by weight of said dianhydrohexitol.
Claim 4
Dependent Claim
30 words
A composition of claim 1 wherein said dianhydrohexitol is selected from the group consisting of methyl isosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide.
Claim 5
Dependent Claim
10 words
A composition of claim 1 wherein said dianhydrohexitol is dimethylisosorbide.
Claim 6
Dependent Claim
21 words
A composition of claim 1 which includes ingredients selected from the group consisting of propylene glycol, glycerine, ethylenediaminetetracidic acid, and methylparaben.
Claim 7
Dependent Claim
42 words
A composition of claim 1 which includes astringents selected from water soluble salts selected from the group consisting of ascorbates, citrates, tartrates, chlorides, fluorides, bromides, sulfates and phosphates of metals selected from the group consisting of sodium, potassium, lithium, magnesium and calcium.
Claim 8
Dependent Claim
24 words
A composition of claim 1 including flavoring agents selected from the group consisting of peppermint, wintergreen, orange, lime, cherry, strawberry, cinnamon, clove, and anise.
Claim 9
Dependent Claim
25 words
A composition of claim 1 comprising distilled water, sodium benzoate, saccharin, citric acid, a surfactant, peppermint oil, clove oil, ethyl alcohol, and a coloring agent.
Claim 10
Dependent Claim
12 words
A composition of claim 1 which contains a therapeutic amount of allantoin.
References Cited (Backward Citations)
US3120469A
Cited
US3342680A
Cited
US3651208A
Cited
US3928555A
Cited
US4002732A
Cited
US4082881A
Cited
US4169152A
Cited
US4425322A
Cited
US4444747A
Cited
US4482536A
Cited
US4525343A
Cited
US4585649A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-09-08 | 1990-03-10 | 1990-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-09-08 | 1994-03-10 | 1994-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-09-08 | 1998-03-10 | 1998-09-09 | $7700.00 | Window Closed / Lapsed |