Isohexide and tetrahydrofuran ethers and their carbamates in method of bringing about relaxation of skeletal musculature

Claim 1

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal therapeutically effective amount of a compound selected from the group consisting of those represented by the formulas: ##STR28## wherein each R 1 is a radical independently selected from the group consisting of hydrogen, aryl, aralkyl where the aralkyl radical contains from 9 to 12 carbon atoms, alkyl substituted aryl, haloalkyl substituted aryl, alkoxy substituted aryl, halogen substituted aryl, alkyl substituted aralkyl, haloalkyl substituted aralkyl, alkoxy substituted aralkyl, mono-halogen substituted aralkyl where the aralkyl radical contains from 7 to 12 carbon atoms, di- and tri-halogen substituted aralkyl where the aralkyl radical contains from 9 to 12 carbon atoms, and ##STR29## and each R 2 is independently selected from the group consisting of hydrogen, aryl, aralkyl, alkyl substituted aryl, haloalkyl substituted aryl, alkoxy substituted aryl, halogen substituted aryl, alkyl substituted aralkyl, haloalkyl substituted aralkyl, alkoxy substituted aralkyl, halogen substituted aralkyl, and ##STR30## with the proviso that at least one R 1 and R 2 in each formula is other than hydrogen or ##STR31##

Claim 2

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal therapeutically effective amount of a compound selected from the group consisting of those represented by the formulas: ##STR28## wherein each R 1 is a radical independently selected from the group consisting of hydrogen, aryl, aralkyl where the aralkyl radical contains from 9 to 12 carbon atoms, alkyl substituted aryl, haloalkyl substituted aryl, alkoxy substituted aryl, halogen substituted aryl, alkyl substituted aralkyl, haloalkyl substituted aralkyl, alkoxy substituted aralkyl, mono-halogen substituted aralkyl where the aralkyl radical contains from 7 to 12 carbon atoms, di- and tri-halogen substituted aralkyl where the aralkyl radical contains from 9 to 12 carbon atoms, and ##STR29## and each R 2 is independently selected from the group consisting of hydrogen, aryl, aralkyl, alkyl substituted aryl, haloalkyl substituted aryl, alkoxy substituted aryl, halogen substituted aryl, alkyl substituted aralkyl, haloalkyl substituted aralkyl, alkoxy substituted aralkyl, halogen substituted aralkyl, and ##STR30## with the proviso that at least one R 1 and R 2 in each formula is other than hydrogen or ##STR31##

Claim 3

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal a therapeutically effective amount of a compound selected from the group consisting of those represented by the formula: ##STR32## wherein each R 1 is a radical independently selected from the group consisting of hydrogen, phenyl, phenylalkyl (C 3 to C 6 ), alkyl (C 1 to C 6 ) substituted phenyl, haloalkyl (C 1 to C 6 ) substituted phenyl, alkoxy (C 1 to C 6 ) substituted phenyl, halogen substituted phenyl, alkyl (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, haloalkyl (C 1 to C 6 ) substituted phenyl alkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, alkoxy (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, di- and tri-halogen substituted phenylalkyl (C 3 to C 6 ) where the substitution is on the phenyl ring, mono-halogen substituted benzyl where the substitution is on the phenyl ring, and ##STR33## with the proviso that at least one R 1 is other than hydrogen or ##STR34##

Claim 4

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal a therapeutically effective amount of a compound selected from the group consisting of those represented by the formula: ##STR32## wherein each R 1 is a radical independently selected from the group consisting of hydrogen, phenyl, phenylalkyl (C 3 to C 6 ), alkyl (C 1 to C 6 ) substituted phenyl, haloalkyl (C 1 to C 6 ) substituted phenyl, alkoxy (C 1 to C 6 ) substituted phenyl, halogen substituted phenyl, alkyl (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, haloalkyl (C 1 to C 6 ) substituted phenyl alkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, alkoxy (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, di- and tri-halogen substituted phenylalkyl (C 3 to C 6 ) where the substitution is on the phenyl ring, mono-halogen substituted benzyl where the substitution is on the phenyl ring, and ##STR33## with the proviso that at least one R 1 is other than hydrogen or ##STR34##

Claim 5

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal a composition comprised of a therapeutically effective amount of a compound selected from the group consisting of those represented by the formulas: ##STR35## wherein each R 3 and R 4 is a radical independently selected from the group consisting of hydrogen, aryl, aralkyl, alkyl substituted aryl, haloalkyl substituted aryl, alkoxy substituted aryl, halogen substituted aryl, alkyl substituted aralkyl, haloalkyl substituted aralkyl, alkoxy substituted aralkyl, halogen substituted aralkyl, and ##STR36## with the proviso that at least one R 3 and R 4 in each formula is other than hydrogen or ##STR37## in a pharmaceutical carrier.

Claim 6

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal a composition comprised of a therapeutically effective amount of a compound selected from the group consisting of those represented by the formulas: ##STR35## wherein each R 3 and R 4 is a radical independently selected from the group consisting of hydrogen, aryl, aralkyl, alkyl substituted aryl, haloalkyl substituted aryl, alkoxy substituted aryl, halogen substituted aryl, alkyl substituted aralkyl, haloalkyl substituted aralkyl, alkoxy substituted aralkyl, halogen substituted aralkyl, and ##STR36## with the proviso that at least one R 3 and R 4 in each formula is other than hydrogen or ##STR37## in a pharmaceutical carrier.

Claim 9

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal a therapeutically effective amount of a compound selected from the group consisting of those represented by the formula: ##STR42## where each R 2 is a radical independently selected from the group consisting of hydrogen, phenyl, phenylalkyl (C 1 to C 6 ), alkyl (C 1 to C 6 ) substituted phenyl, haloalkyl (C 1 to C 6 ) substituted phenyl, alkoxy (C 1 to C 6 ) substituted phenyl, halogen substituted phenyl, alkyl (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, haloalkyl (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, alkoxy (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, halogen substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, and ##STR43## with the proviso that at least one R 2 is other than hydrogen or ##STR44##

Claim 10

A method of bringing about relaxation of skeletal musculature in a mammal comprising administering to a mammal a therapeutically effective amount of a compound selected from the group consisting of those represented by the formula: ##STR42## where each R 2 is a radical independently selected from the group consisting of hydrogen, phenyl, phenylalkyl (C 1 to C 6 ), alkyl (C 1 to C 6 ) substituted phenyl, haloalkyl (C 1 to C 6 ) substituted phenyl, alkoxy (C 1 to C 6 ) substituted phenyl, halogen substituted phenyl, alkyl (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, haloalkyl (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, alkoxy (C 1 to C 6 ) substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, halogen substituted phenylalkyl (C 1 to C 6 ) where the substitution is on the phenyl ring, and ##STR43## with the proviso that at least one R 2 is other than hydrogen or ##STR44##