US4585649A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dentifrice formulation and method of treating teeth, mouth and throat therewith to reduce plaque accumulation and irritation
Assignee: Zeneca Inc
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Filing: 1984-12-21
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Granted: 1986-04-29
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Expires: 2004-12-21
Abstract
Abstract Dentifrice formulations containing monoalkyl and dialkyl ethers of dianhydrohexitols in the form of toothpaste, mouthwash, chewing gum, confections, toothpicks and dental floss are effective in the treatment of oral surfaces and cavities to reduce irritation and plaque accumulation caused by the action of bacteria.
Inventors
- 👤 Matthew J. Lynch
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 07:30
CPC Classifications
A; A61; A61Q; A61Q11/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4973
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
125 words
A method for inhibiting the formation of plaque and calculus and relieving throat irritations in the oral cavity of mammals which comprises periodically treating the surfaces of the throat, mouth, teeth and gums with a mouthwash or gargle composition containing an effective S. mutans inhibiting amount of a dianhydrohexitol compound having the general formula: ##STR2## wherein R' and R" are individually selected from alkyl radicals selected from the group consisting of --CH 3 , --C 2 H 5 , --C 3 H 7 , --C 4 H 9 or --H when the other R' or R" is an alkyl radical of 1-4 carbon atoms whereby at least a portion of the bacteria on said surfaces is essentially inhibited from further growth or removed by dissolution.
Claim 2
Independent Claim
125 words
A method for inhibiting the formation of plaque and calculus and relieving throat irritations in the oral cavity of mammals which comprises periodically treating the surfaces of the throat, mouth, teeth and gums with a mouthwash or gargle composition containing an effective S. mutans inhibiting amount of a dianhydrohexitol compound having the general formula: ##STR2## wherein R' and R" are individually selected from alkyl radicals selected from the group consisting of --CH 3 , --C 2 H 5 , --C 3 H 7 , --C 4 H 9 or --H when the other R' or R" is an alkyl radical of 1-4 carbon atoms whereby at least a portion of the bacteria on said surfaces is essentially inhibited from further growth or removed by dissolution.
Claim 3
Dependent Claim
14 words
A method of claim 1 which comprises gargling with said compound in aqueous solution.
Claim 4
Dependent Claim
22 words
A method of claim 1 which comprises flushing the teeth and gums with a jet of an aqueous solution of said compound.
Claim 5
Dependent Claim
14 words
A method of claim 3 wherein said liquid, contains a therapeutic amount of Allantoin.
Claim 6
Dependent Claim
29 words
A method of claim 1 wherein said dianhydrohexitol is selected from the group consisting of methylisosorbide, dimethylisosorbide, ethylisosorbide, diethylisosorbide, isopropylisosorbide, diisopropylisosorbide, butylisosorbide, dibutylisosorbide, methylethylisosorbide, methylpropylisosorbide, methylbutylisosorbide, ethylpropylisosorbide and ethylbutylisosorbide.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-28 | 1989-10-28 | 1990-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-28 | 1993-10-28 | 1994-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-28 | 1997-10-28 | 1998-04-29 | $7700.00 | Window Closed / Lapsed |