Patent US4607023A successfully refreshed from Google Patents.
US4607023A
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Natriuretic
Assignee: Montreal Clinical Research Institute
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Filing: 1984-08-27
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Granted: 1986-08-19
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Expires: 2004-08-27
Abstract
Abstract Novel peptides in substantially pure form and selected from the group of peptides having the amino acid sequence: X-Cys-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Y-Z wherein Y is selected from the group consisting of -Asn, -Asn-Ser, -Asn-Ser-Phe, -Asn-Ser-Phe-Arg, and -Asn-Ser-Phe-Arg-Tyr; Z is OH or NH 2 ; and X is selected from the group consisting of H, Ser-, Ser-Ser-, Arg-Ser-Ser-, Arg-Arg-Ser-Ser-, Leu-Arg-Arg-Ser-Ser, Ser-Leu-Arg-Arg-Ser-Ser-, Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser, Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser, and Glu-Val-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Gly-Arg-Gly-Pro-Trp-Asp-Pro-Ser-Asp-Arg-Ser-Ala-Leu-Lys-Ser-Lys-Leu-Arg-Ala-Leu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, are disclosed as having diuretic, natriuretic, vasorelaxant, hypotensive or anti-hypertensive properties.
Inventors
- 👤 Gaetan Thibault
- 👤 Raul Garcia
- 👤 Marc Cantin
- 👤 Nabil Seidah
- 👤 Claude Lazure
- 👤 Michel Chretien
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:36
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/58; A; A61; A61K; A61K38/00
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
95 words
A peptide in substantially pure form selected from the group of peptides having the amino acid sequence: ##STR25## wherein Y is selected from the group consisting of -Asn, -Asn-Ser, Asn-Ser-Phe, Asn-Ser-Phe-Arg, and -Asn-Ser-Phe-Arg-Tyr; Z is OH or NH 2 ; and X is selected from the group consisting of H Ser-, Ser-Ser-, Arg-Ser-Ser-, Arg-Arg-Ser-Ser-, Leu-Arg-Arg-Ser-Ser, Ser-Leu-Arg-Arg-Ser-Ser-, Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, and Glu-Val-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Gly-Arg-Gly-Pro-Trp-Asp-Pro-Ser-Asp-Arg-Ser-Ala-Leu-Lys-Ser-Lys-Leu-Arg-Ala-Leu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, with the proviso that when X is H, Ser- or Ser-Ser- Y is not -Ans, Ans-Ans, Ser-Ser-Phe-Arg or Asn-Ser-Phe-Arg-Tyr and with the further provise that when Y is Asn-Ser-Phe-Arg-Tyr X is not Ser-Leu-Arg-Arg-Ser-Ser.
Claim 2
Dependent Claim
95 words
A peptide in substantially pure form selected from the group of peptides having the amino acid sequence: ##STR25## wherein Y is selected from the group consisting of -Asn, -Asn-Ser, Asn-Ser-Phe, Asn-Ser-Phe-Arg, and -Asn-Ser-Phe-Arg-Tyr; Z is OH or NH 2 ; and X is selected from the group consisting of H Ser-, Ser-Ser-, Arg-Ser-Ser-, Arg-Arg-Ser-Ser-, Leu-Arg-Arg-Ser-Ser, Ser-Leu-Arg-Arg-Ser-Ser-, Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, and Glu-Val-Pro-Trp-Thr-Gly-Glu-Val-Asn-Pro-Ser-Gln-Arg-Asp-Gly-Gly-Ala-Leu-Gly-Arg-Gly-Pro-Trp-Asp-Pro-Ser-Asp-Arg-Ser-Ala-Leu-Lys-Ser-Lys-Leu-Arg-Ala-Leu-Leu-Ala-Gly-Pro-Arg-Ser-Leu-Arg-Arg-Ser-Ser-, with the proviso that when X is H, Ser- or Ser-Ser- Y is not -Ans, Ans-Ans, Ser-Ser-Phe-Arg or Asn-Ser-Phe-Arg-Tyr and with the further provise that when Y is Asn-Ser-Phe-Arg-Tyr X is not Ser-Leu-Arg-Arg-Ser-Ser.
Claim 3
Dependent Claim
10 words
A peptide according to claim 1, wherein Y is -Asn-Ser-Phe-Arg-Tyr.
Claim 4
Dependent Claim
56 words
A peptide in a substantially pure form selected from the group consisting of peptides of the formulae: ANF (1-33) represented by the formula ##STR26## ANF (2-33) represented by the formula ##STR27## ANF (3-33) represented by the formula ##STR28## ANF (8-33) represented by the formula ##STR29## in which Z is selected from OH and NH 2 .
Claim 5
Dependent Claim
56 words
A peptide in a substantially pure form selected from the group consisting of peptides of the formulae: ANF (1-33) represented by the formula ##STR26## ANF (2-33) represented by the formula ##STR27## ANF (3-33) represented by the formula ##STR28## ANF (8-33) represented by the formula ##STR29## in which Z is selected from OH and NH 2 .
Claim 6
Dependent Claim
20 words
The substantially pure peptide ANF-H1 of the formula: ##STR30## in which Z is selected from OH and NH 2 .
Claim 7
Dependent Claim
20 words
The substantially pure peptide ANF-H1 of the formula: ##STR30## in which Z is selected from OH and NH 2 .
Claim 8
Dependent Claim
36 words
A method of causing a diuretic, natriuretic, vasorelaxant, hypotensive, or anti-hypertensive response in a patient in need of same which comprises administering to said patient an effective amount of a peptide as claimed in claim 1.
Claim 9
Dependent Claim
27 words
A diuretic, natriuretic, vasorelaxant, hypotensive, or anti-hypertensive pharmaceutical composition comprising an effective amount of a peptide as claimed in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 10
Dependent Claim
35 words
A method of treating congestive heart failure in a patient having same which comprises administering to said patient a peptide as claimed in claim 1 in an amount effective to alleviate said congestive heart failure.
Claim 11
Dependent Claim
31 words
A pharmaceutical composition for treating congestive heart failure comprising an amount of a peptide as claimed in claim 1 to alleviate said congestive heart failure and a pharmaceutically acceptable carrier therefor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-08-18 | 1990-02-17 | 1990-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-08-18 | 1994-02-17 | 1994-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-08-18 | 1998-02-17 | 1998-08-19 | $7700.00 | Window Closed / Lapsed |