Patent US4603135A successfully refreshed from Google Patents.
US4603135A
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Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates
Assignee: Takeda Pharmaceutical Co Ltd
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Filing: 1984-09-25
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Granted: 1986-07-29
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Expires: 2004-09-25
Abstract
Abstract Dihydropyridine derivatives and acid addition salts thereof which are of use as prophylactic or/and therapeutic drugs for cardiovascular diseases, said dihydropyridine derivatives having the formula <IMAGE> wherein R1 is a hydrogen atom or an aryl, R2 and R3 are the same or different and each is an aryl, R4 and R6 are the same or different and each is a lower alkyl, R5 is amino or a lower alkyl, A is an alkylene, X is N or CH and m and n are the same or different and each is 0 or 1, with the proviso that when X is N, R5 is amino.
Inventors
- 👤 Kanji Meguro
- 👤 Akinobu Nagaoka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 15:07
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/10; C07D211/14; C07D211/80; C07D211/84; C07D211/90
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
81 words
A compound of the formula ##STR17## wherein R 1 is hydrogen or phenyl optionally substituted by one or two halo, nitro, trifluoromethyl, C 1-6 -alkyl or C 1-3 -alkoxy groups, R 2 and R 3 are phenyl optionally aubstituted by one or two halo, nitro, trifluoromethyl, C 1-6 -alkyl or C 1-3 -alkoxy groups, R 4 and R 6 are C 1-6 -alkyl, A is C 2-4 -alkylene, m and n are 0 or 1, or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
81 words
A compound of the formula ##STR17## wherein R 1 is hydrogen or phenyl optionally substituted by one or two halo, nitro, trifluoromethyl, C 1-6 -alkyl or C 1-3 -alkoxy groups, R 2 and R 3 are phenyl optionally aubstituted by one or two halo, nitro, trifluoromethyl, C 1-6 -alkyl or C 1-3 -alkoxy groups, R 4 and R 6 are C 1-6 -alkyl, A is C 2-4 -alkylene, m and n are 0 or 1, or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
25 words
A compound claimed in claim 1, wherein R 1 , R 2 and R 3 are the same or different and each is a phenyl.
Claim 4
Dependent Claim
18 words
A compound claimed in claim 1, wherein R 3 is a phenyl which may be optionally be substituted.
Claim 5
Dependent Claim
10 words
A compound claimed claimed claim 1, wherein A is ethylene.
Claim 6
Dependent Claim
11 words
A compound claimed in claim 1, which is 5-[2-(4-benzhydryl-1-piperazinyl)ethyl] 3-ethyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate.
Claim 7
Dependent Claim
11 words
A compound claimed in claim 1 which is 5-[2-[4-(4,4'-dimethylbenzhydryl)-1-piperazinyl]-ethyl] 3-ethyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate.
Claim 8
Dependent Claim
10 words
A compound claimed in claim 1, which is 5-[2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]ethyl]3-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate.
Claim 9
Dependent Claim
10 words
A compound claimed in claim 1, which is 5-[2-[4-(4,4'-dichlorobenzhydryl)-1-piperazinyl]ethyl]3-ethyl 2-amino-4-(2,3-dichlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate.
Claim 10
Dependent Claim
10 words
A compound claimed in claim 1, which is 3-ethyl 5-[2-[4-(4,4'-difluorobenzhydryl)-1-piperazinyl]-ethyl]2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate.
Claim 11
Dependent Claim
26 words
Coronary dilator composition which comprises an effective coronary dilator amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier or diluent therefor.
Claim 12
Dependent Claim
100 words
An anti-hypertensive pharmaceutically composition which comprises an effect anti-hypertensive amount of a compound of the formula ##STR18## wherein R 1 is hydrogen or phenyl optionally substituted by one or two halo, nitro, trifluromethyl, C 1-6 -alkyl or C 1-3 -alkoxy groups, R 2 and R 3 are phenyl optionally substituted by one or two halo, nito, trifluoromethyl, C 1-6 -alkyl or C 1-3 -alkoxy grouns, R 4 and R 6 are C 1-6 -alkyl, A is C 2-4 -alkylene, m and m are 0 or 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent therefor.
Claim 13
Dependent Claim
100 words
An anti-hypertensive pharmaceutically composition which comprises an effect anti-hypertensive amount of a compound of the formula ##STR18## wherein R 1 is hydrogen or phenyl optionally substituted by one or two halo, nitro, trifluromethyl, C 1-6 -alkyl or C 1-3 -alkoxy groups, R 2 and R 3 are phenyl optionally substituted by one or two halo, nito, trifluoromethyl, C 1-6 -alkyl or C 1-3 -alkoxy grouns, R 4 and R 6 are C 1-6 -alkyl, A is C 2-4 -alkylene, m and m are 0 or 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent therefor.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-07-28 | 1990-01-27 | 1990-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-07-28 | 1994-01-27 | 1994-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-07-28 | 1998-01-27 | 1998-07-29 | $7700.00 | Window Closed / Lapsed |