US3985758A
Expired / Lapsed
US
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1,4-Dihydropyridine derivatives
Assignee: Astellas Pharma Inc
•
Filing: 1975-06-06
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Granted: 1976-10-12
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Expires: 1995-06-06
Abstract
Abstract There are provided novel 1,4-dihydropyridine derivatives, particularly 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3- beta -(N-benzyl-N-methylamino)ethyl ester and 5-methyl ester. The 1,4-dihydropyridine derivatives are characterized by cerebral vascular dilator activity.
Inventors
- 👤 Masuo Murakami
- 👤 Kozo Takahashi
- 👤 Masaru Iwanami
- 👤 Masaharu Fujimoto
- 👤 Tadao Shibanuma
- 👤 Ryutaro Kawai
- 👤 Toichi Takenaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:06
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/80; C07D211/84; C07D211/90
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
76 words
A compound of the formula ##SPC10## wherein R represents hydrogen or lower alkyl; R 1 and R 2 each represents methyl; R 3 represents phenyl, benzyl, halobenzyl, lower alkoxy-benzyl; R 4 represents hydrogen, methyl or ethyl; A represents lower alkylene; R 5 represents methyl, or lower alkoxy, or lower alkoxy substituted with lower alkoxy, or ##EQU1## in which R 3 and R 4 have the same meaning as above; and R 6 represents nitro or trifluoromethyl.
Claim 2
Dependent Claim
76 words
A compound of the formula ##SPC10## wherein R represents hydrogen or lower alkyl; R 1 and R 2 each represents methyl; R 3 represents phenyl, benzyl, halobenzyl, lower alkoxy-benzyl; R 4 represents hydrogen, methyl or ethyl; A represents lower alkylene; R 5 represents methyl, or lower alkoxy, or lower alkoxy substituted with lower alkoxy, or ##EQU1## in which R 3 and R 4 have the same meaning as above; and R 6 represents nitro or trifluoromethyl.
Claim 3
Dependent Claim
46 words
The 1,4-dihydropyridine compound as claimed in claim 1 wherein said R is hydrogen, said R 1 and R 2 each represents methyl; said R 3 represents benzyl; said R 4 represents methyl or ethyl; said R 5 represents lower alkoxy; and said R 6 represents nitro.
Claim 4
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino ethyl ester 5-methyl ester.
Claim 5
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino) ethyl ester 5-ethyl ester.
Claim 6
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino) ethyl ester 5-isopropyl ester.
Claim 7
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-ethylamino) ethyl ester 5-isopropyl ester.
Claim 8
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-benzyl-N-methylamino) propyl ester 5-isopropyl ester.
Claim 9
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-p-methoxybenzyl-N-methylamino) ethyl ester 5-ethyl ester.
Claim 10
Dependent Claim
17 words
The 1,4-dihydropyridine compound as claimed in claim 1 which is 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-β-(N-p-chlorobenzyl-N-methylamino) ethyl ester 5-ethyl ester.
References Cited (Backward Citations)
US3905970A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-10-12 | 1980-04-12 | 1980-10-12 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-10-12 | 1984-04-12 | 1984-10-12 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-10-12 | 1988-04-12 | 1988-10-12 | $7700.00 | Window Closed / Lapsed |