Patent US4584195A successfully refreshed from Google Patents.
US4584195A
Expired / Lapsed
US
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Broad spectrum vaccine against gonorrhea
Assignee: Leland Stanford Junior University
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Filing: 1984-06-21
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Granted: 1986-04-22
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Expires: 2004-06-21
Abstract
Abstract Vaccines comprising peptide sequences corresponding to immunorecessive determinants in gonorrhea pilus protein are disclosed. The vaccines are effective in protecting human subjects against infection by a wide range of gonorrhea strains by raising antibodies which interfere with the colonization of the epithelium by the infecting bacteria.
Inventors
- 👤 Gary K. Schoolnik
- 👤 Jonathan Rothbard
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:28
CPC Classifications
A; A61; A61K; A61K38/00; C; C07; C07K; C07K14/00; C07K14/195; C07K14/22; A61K39/00; A61K39/385; A61K2039/60; A61K2039/6031; A61K2039/6081; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
55 words
A vaccine protective against gonorrhea which comprises an effectively protective amount of a peptide having an amino acid sequence that corresponds to residues 41-50 inclusive of N. gonorrhoeae MS11 (Tr) pilin, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 2
Dependent Claim
55 words
A vaccine protective against gonorrhea which comprises an effectively protective amount of a peptide having an amino acid sequence that corresponds to residues 41-50 inclusive of N. gonorrhoeae MS11 (Tr) pilin, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 3
Dependent Claim
17 words
The vaccine of claim 1 wherein the peptide further contains a Cys residue at its C terminus.
Claim 4
Dependent Claim
17 words
The vaccine of claim 1 wherein the peptide further contains a Gly-Cys dipeptide at its C terminus.
Claim 5
Dependent Claim
56 words
A vaccine protective against gonorrhea infections which comprises an effectively protective amount of a peptide having an amino acid sequence that corresponds to residues 69-84 inclusive of N. gonorrhoeae MS11 (Tr) pilin, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 6
Dependent Claim
56 words
A vaccine protective against gonorrhea infections which comprises an effectively protective amount of a peptide having an amino acid sequence that corresponds to residues 69-84 inclusive of N. gonorrhoeae MS11 (Tr) pilin, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 7
Dependent Claim
17 words
The vaccine of claim 4 wherein the peptide further contains a Cys residue at the C terminus.
Claim 8
Dependent Claim
17 words
The vaccine of claim 4 wherein the peptide further contains a Gly-Cys dipeptide at its C terminus.
Claim 9
Dependent Claim
42 words
A vaccine protective against gonorrhea which comprises and effectively protective amount of a peptide of the sequence Glu-Gly-Gln-Lys-Ser-Ala-Val-Thr-Glu-Tyr, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 10
Dependent Claim
42 words
A vaccine protective against gonorrhea which comprises and effectively protective amount of a peptide of the sequence Glu-Gly-Gln-Lys-Ser-Ala-Val-Thr-Glu-Tyr, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 11
Dependent Claim
17 words
The vaccine of claim 7 wherein the peptide further contains a Cys residue at its C terminus.
Claim 12
Dependent Claim
17 words
The vaccine of claim 7 wherein the peptide further contains a Gly-Cys dipeptide at its C terminus.
Claim 13
Dependent Claim
43 words
A vaccine protective against gonorrhea infection which comprises an effectively protective amount of a peptide of the sequence Pro-Pro-Ser-Asp-Ile-Lys-Gly-Lys-Tyr-Val-Lys-Glu-Val-Glu-Val-Lys, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 14
Dependent Claim
43 words
A vaccine protective against gonorrhea infection which comprises an effectively protective amount of a peptide of the sequence Pro-Pro-Ser-Asp-Ile-Lys-Gly-Lys-Tyr-Val-Lys-Glu-Val-Glu-Val-Lys, wherein said peptide optionally further contains a Cys residue or a Gly-Cys dipeptide at its C terminus, linked to a substantially antigenically neutral carrier.
Claim 15
Dependent Claim
16 words
The vaccine of claim 10 wherein the peptide contains a Cys residue at its C terminus.
Claim 16
Dependent Claim
16 words
The vaccine of claim 10 wherein the peptide contains a Gly-Cys dipeptide at its C terminus.
Claim 17
Dependent Claim
19 words
A peptide of the sequence Glu-Gly-Gln-Lys-Ser-Ala-Val-Thr-Glu-Tyr, optionally having a Cys residue or a Gly-Cys dipeptide at its C terminus.
Claim 18
Dependent Claim
19 words
A peptide of the sequence Glu-Gly-Gln-Lys-Ser-Ala-Val-Thr-Glu-Tyr, optionally having a Cys residue or a Gly-Cys dipeptide at its C terminus.
Claim 19
Dependent Claim
18 words
A peptide of the sequence Pro-Pro-Ser-Asp-Ile-Lys-Gly-Lys-Tyr-Val-Lys-Glu-Val-Glu-Val-Lys optionally having a Cys residue or Gly-Cys dipeptide at its C terminus.
Claim 20
Dependent Claim
18 words
A peptide of the sequence Pro-Pro-Ser-Asp-Ile-Lys-Gly-Lys-Tyr-Val-Lys-Glu-Val-Glu-Val-Lys optionally having a Cys residue or Gly-Cys dipeptide at its C terminus.
References Cited (Backward Citations)
US4443431A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-04-21 | 1989-10-21 | 1990-04-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-04-21 | 1993-10-21 | 1994-04-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-04-21 | 1997-10-21 | 1998-04-22 | $7700.00 | Window Closed / Lapsed |