US4443431A
Expired / Lapsed
US
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Neisseria gonorrhoeae vaccine
Assignee: United States Department of Health and Human Services
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Filing: 1981-05-27
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Granted: 1984-04-17
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Expires: 2001-05-27
Abstract
Abstract A vaccine affording protection against attachment of Neisseria gonorrhoeae (N.g.) to human cells, and consequent infection, is prepared from a fragment of pili protein isolated from gonococci. This fragment contains the shared antigens between pili from different N.g., in an exposed form.
Inventors
- 👤 Thomas M. Buchanan
- 👤 William Pearce
- 👤 Kirk C. S. Chen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-29 02:36
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/195; C07K14/22; A; A61; A61K; A61K39/00; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/82; Y10S530/825
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
76 words
A cleaved fragment of purified pili protein from Neisseria gonorrhoeae comprising a CNI fragment which is the largest fragment obtained by cleavage of the purified pili protein at the methionine residues thereof, said fragment being further characterized by: (a) an amino acid sequence different from the amino acid sequences of the other fragments; (b) containing an antigen common to most pili of Neisseria gonorrhoeae; and (c) being the only fragment obtained capable of binding to cells.
Claim 2
Dependent Claim
76 words
A cleaved fragment of purified pili protein from Neisseria gonorrhoeae comprising a CNI fragment which is the largest fragment obtained by cleavage of the purified pili protein at the methionine residues thereof, said fragment being further characterized by: (a) an amino acid sequence different from the amino acid sequences of the other fragments; (b) containing an antigen common to most pili of Neisseria gonorrhoeae; and (c) being the only fragment obtained capable of binding to cells.
Claim 3
Dependent Claim
31 words
The cleaved fragment of claim 1, wherein said fragment is characterized by stimulating in mammals antibody production to at least one antigen common to pili of most strains of Neisseria gonorrhoeae.
Claim 4
Dependent Claim
28 words
A vaccine for protecting animals against Neisseria gonorrhoeae infection consisting essentially of an effective amount of the cleaved fragment of claim 1 admixed with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
12 words
The vaccine of claim 3 in admixture with a pharmaceutically acceptable adjuvant.
Claim 6
Dependent Claim
15 words
The vaccine of claim 4, wherein said pharmaceutically acceptable adjuvant is an aluminum hydroxide gel.
Claim 7
Dependent Claim
19 words
The vaccine of claim 3, wherein the vaccine contains a concentration of said fragment of 0.5 to 2.0 mg/ml.
Claim 8
Dependent Claim
26 words
A method of protecting mammals against infection by Neisseria gonorrhoeae microorganisms comprising administering an immunologically effective amount of the vaccine of claim 3 to a mammal.
Claim 9
Dependent Claim
13 words
The method of claim 7, wherein the mammal being protected is a human.
Claim 10
Dependent Claim
11 words
The method of claim 8, wherein the vaccine is administered intramuscularly.
Claim 11
Dependent Claim
11 words
The method of claim 8, wherein the vaccine is administered subcutaneously.
Claim 12
Dependent Claim
24 words
The method of claim 8 or claim 10, wherein the vaccine is administered in an amount containing 100 to 500 micrograms of pili protein.
Claim 13
Dependent Claim
11 words
The method of claim 8, wherein the vaccine is administered locally.
Claim 14
Dependent Claim
15 words
The method of claim 12, wherein the vaccine is injected at the site of infection.
Claim 15
Dependent Claim
11 words
The method of claim 11, wherein the vaccine is applied topically.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1987-04-17 | 1987-10-17 | 1988-04-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1991-04-17 | 1991-10-17 | 1992-04-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1995-04-17 | 1995-10-17 | 1996-04-17 | $7700.00 | Window Closed / Lapsed |