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US4567166A Expired / Lapsed US ⏱️ 0.0 years remaining

Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension

Assignee: ER Squibb and Sons LLC
•
Filing: 1984-03-19
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Granted: 1986-01-28
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Expires: 2004-03-19
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Abstract

Abstract Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.

Inventors

  • 👤 Donald S. Karanewsky
  • 👤 Edward W. Petrillo, Jr.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-07 01:05
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61K; A61K31/00; A61K31/66; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/30; C07F9/301; C07F9/32; C07F9/3205; C07F9/3211; C07F9/48; C07F9/4808; C07F9/4816; C07F9/547; C07F9/553; C07F9/5537; C07F9/572; C07F9/5728; C07F9/645; C07F9/6503; C07F9/6506; C07F9/6536; C07F9/6539; C07F9/6561; C07F9/65615

Claims Analysis

Total Claims: 13
Claim 1
Independent Claim 125 words
A compound of the formula ##STR131## wherein X is an imino acid of the formula ##STR132## n is an integer of from 4 to 8; n' is zero or one; R 2 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl; R 1 and R 6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR133## wherein R 14 is hydrogen, lower alkyl, cycloalkyl or phenyl, and R 15 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 14 and R 15 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR134## and when either or both of R 1 and R 6 are hydrogen a basic addition salt or an amino acid addition salt thereof.
Claim 2
Dependent Claim 125 words
A compound of the formula ##STR131## wherein X is an imino acid of the formula ##STR132## n is an integer of from 4 to 8; n' is zero or one; R 2 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl; R 1 and R 6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR133## wherein R 14 is hydrogen, lower alkyl, cycloalkyl or phenyl, and R 15 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 14 and R 15 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR134## and when either or both of R 1 and R 6 are hydrogen a basic addition salt or an amino acid addition salt thereof.
Claim 3
Dependent Claim 11 words
A compound of claim 1 wherein n is 4 to 7.
Claim 4
Dependent Claim 13 words
A compound of claim 1 wherein R 1 is hydrogen or alkali metal.
Claim 5
Dependent Claim 21 words
The compound of claim 1 wherein n is 6, R 1 is hydrogen, n' is 0, and R 2 is hydrogen.
Claim 6
Dependent Claim 9 words
The lithium salt of the compound of claim 3.
Claim 7
Dependent Claim 12 words
The compound of claim 4 wherein R 1 is hydrogen or ##STR135##
Claim 8
Dependent Claim 34 words
The compound of claim 1 wherein R 6 is hydrogen or ##STR136## wherein R 14 is hydrogen, methyl, cyclopentyl or cyclohexyl and R 15 is lower alkyl of 1 to 4 carbons or phenyl.
Claim 9
Dependent Claim 9 words
The compound of claim 1 wherein X is ##STR137##
Claim 10
Dependent Claim 9 words
The compound of claim 1 wherein X is ##STR138##
Claim 11
Dependent Claim 9 words
The compound of claim 1 wherein X is ##STR139##
Claim 12
Dependent Claim 29 words
A pharmaceutical composition useful for treating hypertension comprising a pharmaceutically acceptable carrier and an effective amount of one or more compounds of claim 1 or pharmaceutically acceptable salts thereof.
Claim 13
Dependent Claim 20 words
The method of treating hypertension in a mammalian specie comprising administering an effective amount of the composition of claim 11.

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1989-01-27 1989-07-29 1990-01-28 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1993-01-27 1993-07-29 1994-01-28 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1997-01-27 1997-07-29 1998-01-28 $7700.00 Window Closed / Lapsed

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