Patent US4567166A successfully refreshed from Google Patents.
US4567166A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Amino and substituted amino phosphinylalkanoyl compounds useful for treating hypertension
Assignee: ER Squibb and Sons LLC
•
Filing: 1984-03-19
•
Granted: 1986-01-28
•
Expires: 2004-03-19
Abstract
Abstract Compounds of the formula ##STR1## wherein X is an amino acid or ester are useful hypotensive agents due to their angiotensin converting enzyme inhibition activity.
Inventors
- 👤 Donald S. Karanewsky
- 👤 Edward W. Petrillo, Jr.
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 01:05
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61K; A61K31/00; A61K31/66; C07F; C07F9/00; C07F9/02; C07F9/28; C07F9/30; C07F9/301; C07F9/32; C07F9/3205; C07F9/3211; C07F9/48; C07F9/4808; C07F9/4816; C07F9/547; C07F9/553; C07F9/5537; C07F9/572; C07F9/5728; C07F9/645; C07F9/6503; C07F9/6506; C07F9/6536; C07F9/6539; C07F9/6561; C07F9/65615
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
125 words
A compound of the formula ##STR131## wherein X is an imino acid of the formula ##STR132## n is an integer of from 4 to 8; n' is zero or one; R 2 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl; R 1 and R 6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR133## wherein R 14 is hydrogen, lower alkyl, cycloalkyl or phenyl, and R 15 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 14 and R 15 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR134## and when either or both of R 1 and R 6 are hydrogen a basic addition salt or an amino acid addition salt thereof.
Claim 2
Dependent Claim
125 words
A compound of the formula ##STR131## wherein X is an imino acid of the formula ##STR132## n is an integer of from 4 to 8; n' is zero or one; R 2 is hydrogen, lower alkyl, halo substituted lower alkyl, benzyl or phenethyl; R 1 and R 6 are independently selected from hydrogen, lower alkyl, benzyl, benzhydryl, or ##STR133## wherein R 14 is hydrogen, lower alkyl, cycloalkyl or phenyl, and R 15 is hydrogen, lower alkyl, lower alkoxy, phenyl, or R 14 and R 15 taken together are --(CH 2 ) 2 --, --(CH 2 ) 3 --, --CH═CH--, or ##STR134## and when either or both of R 1 and R 6 are hydrogen a basic addition salt or an amino acid addition salt thereof.
Claim 3
Dependent Claim
11 words
A compound of claim 1 wherein n is 4 to 7.
Claim 4
Dependent Claim
13 words
A compound of claim 1 wherein R 1 is hydrogen or alkali metal.
Claim 5
Dependent Claim
21 words
The compound of claim 1 wherein n is 6, R 1 is hydrogen, n' is 0, and R 2 is hydrogen.
Claim 6
Dependent Claim
9 words
The lithium salt of the compound of claim 3.
Claim 7
Dependent Claim
12 words
The compound of claim 4 wherein R 1 is hydrogen or ##STR135##
Claim 8
Dependent Claim
34 words
The compound of claim 1 wherein R 6 is hydrogen or ##STR136## wherein R 14 is hydrogen, methyl, cyclopentyl or cyclohexyl and R 15 is lower alkyl of 1 to 4 carbons or phenyl.
Claim 9
Dependent Claim
9 words
The compound of claim 1 wherein X is ##STR137##
Claim 10
Dependent Claim
9 words
The compound of claim 1 wherein X is ##STR138##
Claim 11
Dependent Claim
9 words
The compound of claim 1 wherein X is ##STR139##
Claim 12
Dependent Claim
29 words
A pharmaceutical composition useful for treating hypertension comprising a pharmaceutically acceptable carrier and an effective amount of one or more compounds of claim 1 or pharmaceutically acceptable salts thereof.
Claim 13
Dependent Claim
20 words
The method of treating hypertension in a mammalian specie comprising administering an effective amount of the composition of claim 11.
References Cited (Backward Citations)
US4105776A
Cited
US4192878A
Cited
BE868532A
Cited
US4151172A
Cited
US4129566A
Cited
US4154935A
Cited
GB2027025A
Cited
GB2028327A
Cited
US4168267A
Cited
GB2039478A
Cited
US4217359A
Cited
US4234489A
Cited
US4303583A
Cited
US4337201A
Cited
US4374131A
Cited
US4381297A
Cited
US4483850A
Cited
US4444765A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-27 | 1989-07-29 | 1990-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-27 | 1993-07-29 | 1994-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-27 | 1997-07-29 | 1998-01-28 | $7700.00 | Window Closed / Lapsed |