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US4567163A
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US
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Salicyclic acid derivatives of N-acetylcysteine and pharmacological use thereof
Assignee: Wilton Licensing AG
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Filing: 1982-11-16
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Granted: 1986-01-28
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Expires: 2002-11-16
Abstract
Abstract The thioester of N-acetylcysteine with salicylic acid and the pharmacologically acceptable and non-toxic organic and inorganic salts thereof, exhibit anti-pyretic, anti-inflammatory and analgesic activity as well as mucolytic activity. The compounds are prepared by the reaction of N-acetylcysteine with either the acid chloride of acetylsalicylic acid or with the mixed anhydride formed from acetylsalicylic acid and ethyl chloroformate, the reaction taking place in an aqueous medium and at low temperature.
Inventors
- 👤 Osvaldo Ponchiroli
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 20:21
CPC Classifications
C; C07; C07C; C07C323/00; C07C323/50; C07C323/51; C07C323/57; C07C323/58; C07C323/59; C07H; C07H17/00; C07H17/04; C07H17/08; A; A61; A61P; A61P11/00; A61P11/10; A61P25/00; A61P25/04; A61P29/00
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
27 words
A compound of the formula: ##STR2## wherein X is selected from the group consisting of hydrogen, alkali metals, alkaline earth metals, and the radicals of organic bases.
Claim 2
Dependent Claim
27 words
A compound of the formula: ##STR2## wherein X is selected from the group consisting of hydrogen, alkali metals, alkaline earth metals, and the radicals of organic bases.
Claim 3
Dependent Claim
15 words
The compound according to claim 1, wherein said organic base is a basic amino acid.
Claim 4
Dependent Claim
21 words
The compound according to claim 2, wherein said basic amino acid is selected from the group consisting of lysine and arginine.
Claim 5
Dependent Claim
14 words
The compound according to claim 1, wherein said organic base is a basic antibiotic.
Claim 6
Dependent Claim
22 words
The compound according to claim 4, wherein said basic antibiotic is selected from the group consisting of erythromycin, propionylerythromycin, neomycin and mechlocycline.
Claim 7
Dependent Claim
12 words
The compound according to claim 1, wherein said alkali metal is sodium.
Claim 8
Dependent Claim
23 words
A pharmaceutical composition having anti-pyretic, anti-inflammatory, analgesic and mucolytic activity, comprising an effective amount for said activity of the compound of claim 1.
Claim 9
Dependent Claim
17 words
The pharmaceutical composition according to claim 7, in suitable form for oral, parenteral, rectal and topical administration.
Claim 10
Dependent Claim
28 words
A pharmaceutical composition in suitable form for topical administration, having dermatological activity, comprising a dermatologically effective amount of the mechlocycline salt of the compound according to claim 1.
References Cited (Backward Citations)
US4268456A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1989-01-27 | 1989-07-29 | 1990-01-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1993-01-27 | 1993-07-29 | 1994-01-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1997-01-27 | 1997-07-29 | 1998-01-28 | $7700.00 | Window Closed / Lapsed |