Patent US4562075A successfully refreshed from Google Patents.
US4562075A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Penetration enhancers for transdermal drug delivery of systemic agents
Assignee: Discovery Therapeutics Inc
•
Filing: 1983-07-25
•
Granted: 1985-12-31
•
Expires: 2003-07-25
Abstract
Abstract In a method for administering systemically active agents including therapeutic agents through the skin or other body membranes of humans and animals typically in the form of a transdermal device or formulation, the improvement comprising the use therewith of an effective amount of a membrane penetration enhancer having the structural formula. ##STR1## wherein R is H or a lower alkyl group, m is 5-7 and n is 0-17.
Inventors
- 👤 Vithal J. Rajadhyaksha
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 19:29
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0014; A61K47/00; A61K47/06; A61K47/22; A61K8/00; A61K8/18; A61K8/30; A61K8/49; A61K8/4906; A61Q; A61Q19/00
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
80 words
A method for administering a systemically active gent, comprising the step of applying a transdermal device or formulation to the skin or mucosal membrane of a human or animal said device or formulation containing a systemically active agent and an effective amount of a membrane penetration enhancer having the structural formula ##STR3## where R is H or a lower alkyl group having 1-4 carbon atoms and n is 0-17, to deliver the systemically-active agent through the skin or mucosal membrane.
Claim 2
Independent Claim
80 words
A method for administering a systemically active gent, comprising the step of applying a transdermal device or formulation to the skin or mucosal membrane of a human or animal said device or formulation containing a systemically active agent and an effective amount of a membrane penetration enhancer having the structural formula ##STR3## where R is H or a lower alkyl group having 1-4 carbon atoms and n is 0-17, to deliver the systemically-active agent through the skin or mucosal membrane.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein R is H.
Claim 4
Dependent Claim
9 words
The method of claim 2 wherein n is 0-11.
Claim 5
Dependent Claim
14 words
The method of claim 1 wherein the systemically active agent is a therapeutic agent.
Claim 6
Dependent Claim
10 words
The method of claim 4 wherein the administration is concurrent.
Claim 7
Independent Claim
80 words
A method for administering a systemically active agent, comprising the step of applying a transdermal device or formulation to the skin or mucosal membrane of a human or animal, said device or formulation containing a systemically active agent and an effective amount of a membrane penetration enhancer having the structural formula ##STR4## where R is H or a lower alkyl group having 1-4 carbon atoms and n is 0-17, to deliver the systemically-active agent through the skin or mucosal membrane.
Claim 8
Independent Claim
80 words
A method for administering a systemically active agent, comprising the step of applying a transdermal device or formulation to the skin or mucosal membrane of a human or animal, said device or formulation containing a systemically active agent and an effective amount of a membrane penetration enhancer having the structural formula ##STR4## where R is H or a lower alkyl group having 1-4 carbon atoms and n is 0-17, to deliver the systemically-active agent through the skin or mucosal membrane.
Claim 9
Dependent Claim
9 words
The method of claim 6, wherein R is H.
Claim 10
Dependent Claim
9 words
The method of claim 7, wherein n is 0-11.
Claim 11
Dependent Claim
14 words
The method of claim 6, wherein the systemically active agent is a therapeutic agent.
Claim 12
Dependent Claim
10 words
The method of claim 9, wherein the administration is concurrent.
References Cited (Backward Citations)
US3989816A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-30 | 1989-07-01 | 1989-12-31 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-30 | 1993-07-01 | 1993-12-31 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-30 | 1997-07-01 | 1997-12-31 | $7700.00 | Window Closed / Lapsed |