Patent US4560692A successfully refreshed from Google Patents.
US4560692A
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4-Piperidino-2-phenylquinolines
Assignee: Hoffmann La Roche Inc
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Filing: 1984-07-18
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Granted: 1985-12-24
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Expires: 2004-07-18
Abstract
Abstract Disclosed are compounds of the formula <IMAGE> I wherein: R1 and R2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R3 and R4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R3 and R4 cannot both be hydrogen. These compounds are useful as anticonvulsant or anxiolytic agents.
Inventors
- 👤 George F. Field
- 👤 William J. Zally
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:30
CPC Classifications
C; C07; C07D; C07D213/00; C07D213/02; C07D213/04; C07D213/60; C07D213/78; C07D213/79; A; A61; A61P; A61P25/00; A61P25/08; A61P25/20; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; C07D211/62; C07D213/81; C07D215/00; C07D215/02; C07D215/16; C07D215/18; C07D215/20; C07D215/22; C07D215/233; C07D215/48; C07D215/50; C07D215/52; C07D401/00; C07D401/02; C07D401/04
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
61 words
A compound of the formula ##STR14## wherein: R 1 and R 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 2
Dependent Claim
61 words
A compound of the formula ##STR14## wherein: R 1 and R 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 3
Dependent Claim
27 words
A compound of formula I, according to claim 1, wherein R 1 and R 2 are selected from the group consisting of a hydrogen, methyl and ethyl.
Claim 4
Dependent Claim
24 words
A compound of formula 1, according to claim 1, wherein R 3 is selected from the group consisting of Cl, Br, methyl and ethyl.
Claim 5
Dependent Claim
12 words
In accordance with claim 1, a compound which is a 1-[2-(4-halophenyl)-4-quinolinyl]-N-lower alkyl-4-piperidinecarboxamide.
Claim 6
Dependent Claim
8 words
In accordance with claim 4, the compound 1-[2-(4-chlorophenyl)-4-quinolinyl]-N-methyl-4-piperidine-carboxamide.
Claim 7
Dependent Claim
8 words
In accordance with claim 1, the compound 1-[2-(4-chlorophenyl)-6-fluoro-4-quinolinyl]-4-piperidinecarboxamide.
Claim 8
Dependent Claim
8 words
In accordance with claim 4, the compound 1-[2-(4-chlorophenyl)-4-quinolinyl]-N-ethyl-4-piperidinecarboxamide.
Claim 9
Dependent Claim
8 words
In accordance with claim 1, the compound 1-[2-(4-chlorophenyl)-4-quinolinyl]-4-piperidinecarboxamide.
Claim 10
Independent Claim
83 words
A method for treating convulsive seizures or anxiety which comprises administering, to a host requiring such treatment, a therapeutically effective amount of a compound of the formula ##STR15## wherein: R 1 and R 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 11
Independent Claim
83 words
A method for treating convulsive seizures or anxiety which comprises administering, to a host requiring such treatment, a therapeutically effective amount of a compound of the formula ##STR15## wherein: R 1 and R 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 12
Dependent Claim
82 words
A pharmaceutical composition for the treatment of convulsive seizures or anxiety comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula ##STR16## wherein: R 1 and R 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 13
Dependent Claim
82 words
A pharmaceutical composition for the treatment of convulsive seizures or anxiety comprising a pharmaceutically acceptable carrier and an effective amount of a compound of the formula ##STR16## wherein: R 1 and R 2 may be either the same or different and each is hydrogen or lower alkyl; and wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 14
Dependent Claim
45 words
A compound of the formula ##STR17## wherein R is lower alkyl and R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 15
Dependent Claim
45 words
A compound of the formula ##STR17## wherein R is lower alkyl and R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 16
Dependent Claim
40 words
A compound of the formula ##STR18## wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 17
Dependent Claim
40 words
A compound of the formula ##STR18## wherein R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 18
Dependent Claim
46 words
A compound of the formula ##STR19## wherein X is a halogen atom and R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
Claim 19
Dependent Claim
46 words
A compound of the formula ##STR19## wherein X is a halogen atom and R 3 and R 4 may be either the same or different and each is hydrogen, halogen, or lower alkyl, with the proviso that R 3 and R 4 cannot both be hydrogen.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-12-23 | 1989-06-24 | 1989-12-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-23 | 1993-06-24 | 1993-12-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-23 | 1997-06-24 | 1997-12-24 | $7700.00 | Window Closed / Lapsed |