US4299835A
Expired / Lapsed
US
⏱️ 0.0 years remaining
4-[(3-(4-Quinolyl)propyl])piperidines, their preparation and their use as medicines
Assignee: Pharmindustrie
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Filing: 1980-11-24
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Granted: 1981-11-10
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Expires: 2000-11-24
Abstract
Abstract Pharmaceutical preparations containing as active ingredient a compound having the formula: ##STR1## wherein R represents hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; and X represents hydrogen, alkyl, alkoxy or alkylthio, the alkyl groups of each containing 1 to 4 carbon atoms, halogen (chlorine, fluorine, bromine or iodine), trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups or by acyl or alkylsulphonyl, the alkyl groups of each containing 1 to 4 carbon atoms, which are particularly advantageous for the treatment of pathological states caused by a disturbance in the functioning of the serotoninergical systems in mammals. These preparations may also be used as anxiolytics.
Inventors
- 👤 Alain A. Champseix
- 👤 Claude G. A. Gueremy
- 👤 Gerard R. Le Fur
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:54
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
113 words
A method of treating a mammal afflicted with an anxiety state comprising administering to said mammal a therapeutically effective amount of a composition comprising a compound of the formula: ##STR9## wherein R is hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; X is hydrogen or halogen, alkyl, alkoxy or alkylthio having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups having 1 to 4 carbon atoms, by acyl having 1 to 4 carbon atoms or by alkylsulphonyl group having 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier therefor.
Claim 2
Independent Claim
113 words
A method of treating a mammal afflicted with an anxiety state comprising administering to said mammal a therapeutically effective amount of a composition comprising a compound of the formula: ##STR9## wherein R is hydrogen, alkyl having 1 to 4 carbon atoms or alkenyl having 2 to 4 carbon atoms; X is hydrogen or halogen, alkyl, alkoxy or alkylthio having 1 to 4 carbon atoms, trifluoromethyl, nitro, hydroxy, amino or amino substituted by one or two alkyl groups having 1 to 4 carbon atoms, by acyl having 1 to 4 carbon atoms or by alkylsulphonyl group having 1 to 4 carbon atoms, or a pharmaceutically acceptable salt thereof in a pharmaceutically acceptable carrier therefor.
Claim 3
Dependent Claim
30 words
A method as defined in claim 1 wherein said compound corresponds to formula (I) wherein R is hydrogen, ethyl or vinyl and X is hydrogen or methoxy in position 6.
Claim 4
Dependent Claim
14 words
The method as defined in claim 1 wherein said compound is 4(R)-[3-(6-methoxy 4-quinolyl)propyl]3(R)-vinyl piperidine.
Claim 5
Dependent Claim
13 words
The method as defined in claim 1 wherein said compound is 4(R)-[3-(4-quinolyl)propyl]3(R)-vinyl piperidine.
Claim 6
Dependent Claim
13 words
The method as defined in claim 1 wherein said compound is 4(R)-[3-(6-methoxy-4-quinolyl)propyl]3(R)-ethyl piperidine.
Claim 7
Dependent Claim
12 words
The method as defined in claim 1 wherein said compound is 4-[3-(4-quinolyl)propyl]piperidine.
Claim 8
Dependent Claim
13 words
The method as defined in claim 1 wherein said compound is 4(R)-[3-(4-quinolyl)propyl]3(R)-ethyl piperidine.
Claim 9
Dependent Claim
12 words
The method of claim 1 wherein said compound is 4(R)-[3-(6-methoxy 4-quinolyl)propyl]3(S)-vinyl piperidine.
Claim 10
Dependent Claim
12 words
The method of claim 1 wherein said compound is 4(R)-[3-(6-methoxy 4-quinolyl)propyl]3(S)-ethyl piperidine.
Claim 11
Dependent Claim
12 words
The method of claim 1 wherein said compound is 4(R)-[3-(4-quinolyl)propyl]3(S) -vinyl piperidine.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-11-09 | 1985-05-11 | 1985-11-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-11-09 | 1989-05-11 | 1989-11-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-11-09 | 1993-05-11 | 1993-11-10 | $7700.00 | Window Closed / Lapsed |