Patent US4559145A successfully refreshed from Google Patents.
US4559145A
Expired / Lapsed
US
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Process for preparing a zero standard serum
Assignee: AMF Inc
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Filing: 1982-06-16
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Granted: 1985-12-17
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Expires: 2002-06-16
Abstract
Abstract A method for the removal of thyroid or steroid hormones from whole human serum which comprises: contacting, at a pressure higher than 1 psi and pH of either 9.0-12.0 (thyroid hormones) or 4.0-6.0 (steroid hormones) the serum with a composite sheet, the composite sheet comprising a matrix of self-bonding fibers having interdispersed therein carbon particles, such that better than 90% of the carbon particles have an average diameter less than about 50 microns; and recovering a whole human serum having substantially undetectable amounts of hormones.
Inventors
- 👤 Kenneth C. Hou
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 14:48
CPC Classifications
B; B01; B01D; B01D15/00; B01D15/08; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N2496/00; G01N2496/05; G01N33/74; G01N33/78; Y; Y10; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
77 words
A method for the removal of thyroid hormones from human serum which comprises: contacting, at a pressure differential higher than 1 psi and at a pH of 9.0 to 12.0 said serum with a composite sheet, said composite sheet consisting essentially of a matrix of self-bonding fibers having interdispersed therein carbon particles and up to 1% of a binder, such that better than 90% of said carbon particles have an average diameter less than about 50 microns.
Claim 2
Independent Claim
77 words
A method for the removal of thyroid hormones from human serum which comprises: contacting, at a pressure differential higher than 1 psi and at a pH of 9.0 to 12.0 said serum with a composite sheet, said composite sheet consisting essentially of a matrix of self-bonding fibers having interdispersed therein carbon particles and up to 1% of a binder, such that better than 90% of said carbon particles have an average diameter less than about 50 microns.
Claim 3
Dependent Claim
19 words
The method of claim 1 wherein said hormones are selected from the group consisting of thyroxine, and triiodo thyronine.
Claim 4
Independent Claim
77 words
A method for the removal of steroid hormones from human serum which comprises: contacting, at a pressure differential higher than 1 psi and at a pH of 4.0 to 6.0 said serum with a composite sheet, said composite sheet consisting essentially of a matrix of self-bonding fibers having interdispersed therein carbon particles and up to 1% of a binder, such that better than 90% of said carbon particles have an average diameter less than about 50 microns.
Claim 5
Independent Claim
77 words
A method for the removal of steroid hormones from human serum which comprises: contacting, at a pressure differential higher than 1 psi and at a pH of 4.0 to 6.0 said serum with a composite sheet, said composite sheet consisting essentially of a matrix of self-bonding fibers having interdispersed therein carbon particles and up to 1% of a binder, such that better than 90% of said carbon particles have an average diameter less than about 50 microns.
Claim 6
Dependent Claim
11 words
The method of claim 3 wherein said steroid hormone is cortisol.
Claim 7
Independent Claim
15 words
The method of any of claims 1 or 3 wherein said pressure is 1-200 psi.
Claim 8
Independent Claim
19 words
The method of any of claims 1 or 3 wherein said composite sheet comprises cellulose fiber and activated carbon.
Claim 9
Dependent Claim
21 words
The method of claim 6 wherein said cellulose fiber comprises 2-10: 1 by weight ratio of unrefined to highly refined pulp.
Claim 10
Dependent Claim
24 words
The method of claim 7 wherein said highly refined pulp has a Canadian Standard Freeness (CSF) value in the range +100 to -600 ml.
Claim 11
Dependent Claim
22 words
The method of claim 7 wherein said unrefined pulp has a Canadian Standard Freeness value in the range +400 to +800 ml.
Claim 12
Dependent Claim
18 words
The method of claim 6 wherein said unrefined pulp comprises 10-30% of the total weight of the sheet.
Claim 13
Dependent Claim
19 words
The method of claim 6 wherein said highly refined pulp comprises 1-15% of the total weight of the sheet.
Claim 14
Dependent Claim
32 words
The method of claim 6 wherein said unrefined pulp comprises 18-20% of the total weight of the sheet, and said highly refined pulp comprises 8-10% of the total weight of the sheet.
Claim 15
Dependent Claim
16 words
The method of claim 6 wherein said carbon is present in said sheet in hormone-adsorbing amounts.
Claim 16
Dependent Claim
17 words
The method of claim 13 wherein said amount is 10-90% of the total weight of said sheet.
Claim 17
Dependent Claim
20 words
The method of claim 6 wherein said sheet also comprises hormone adsorbing amounts of hormone adsorbing materials other than carbon.
Claim 18
Independent Claim
31 words
The method of any of claims 1 or 3 wherein said recovered whole human serum has less than 5 nanograms/dl of T 3 , of cortisol, and of T 4 therein.
Claim 19
Independent Claim
32 words
The method of any of claims 1 or 3 wherein said composite sheet is present in the form of a plurality of essentially circular pads fitting the inside of a cylindrical column.
Claim 20
Dependent Claim
25 words
The method of claim 17 wherein the starting whole serum is allowed to flow through the column and sequentially contact each of said circular pads.
Claim 21
Dependent Claim
14 words
The method of claim 18 wherein said serum is recycled through said pad-containing column.
Claim 22
Dependent Claim
17 words
The method of claim 1 or 3, wherein said binder is melamine, a polyamine, or a polyamid.
Claim 23
Dependent Claim
14 words
The method of claim 1 or 3, wherein said fibers are natural cellulose fibers.
Claim 24
Dependent Claim
23 words
The method of claim 21, wherein said natural cellulose fibers are manila hemp, jute, caroa, sissal, bleached or unbleached craft, or kozu fibers.
References Cited (Backward Citations)
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1988-12-16 | 1989-06-17 | 1989-12-17 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-12-16 | 1993-06-17 | 1993-12-17 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-12-16 | 1997-06-17 | 1997-12-17 | $7700.00 | Window Closed / Lapsed |