Patent US4551307A successfully refreshed from Google Patents.
US4551307A
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Analytical element
Assignee: Konica Minolta Inc
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Filing: 1982-05-25
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Granted: 1985-11-05
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Expires: 2002-05-25
Abstract
Abstract There is disclosed an analytical element comprising a light-transmissive and liquid-impermeable support and at least one developing layer of a fibrous structure containing at least one kind of interactive composition reactive with a component in a liquid sample, characterized in that the fiber constituting the developing layer of a fibrous structure and the interactive composition are bonded to each other by a compound having a reactive group. A quantitative analysis of a specific component in a liquid sample can effectively be carried out by using the analytical element according to this invention.
Inventors
- 👤 Mikio Koyama
- 👤 Shozo Kikugawa
- 👤 Kenichiro Okaniwa
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-31 12:50
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/52; G01N33/525; Y; Y10; Y10S; Y10S435/00; Y10S435/805
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
167 words
An analytical element for detecting a component in a liquid sample, said analytical element containing a light-transmissive and liquid-impermeable support and at least one developing layer having a fibrous structure, said fibrous structure comprising fibers which are loose and randomly entangled with each other in said at least one developing layer, said fibers having a size of from 50 to 325 mesh, said at least one developing layer containing at least one interactive composition capable of reacting with said component to be detected and said interactive composition being bound to the fibers of said developing layer through a compound having a first reactive group for binding to said fibers and a second reactive group for binding to said interactive composition, and a portion of said reactive groups of said compound being bound to at least one of each other and groups in a binder or adjacent layers, thereby increasing the mechanical strength of the developing layer of fibrous structure and greatly enhancing adhesion to the adjacent layers.
Claim 2
Dependent Claim
167 words
An analytical element for detecting a component in a liquid sample, said analytical element containing a light-transmissive and liquid-impermeable support and at least one developing layer having a fibrous structure, said fibrous structure comprising fibers which are loose and randomly entangled with each other in said at least one developing layer, said fibers having a size of from 50 to 325 mesh, said at least one developing layer containing at least one interactive composition capable of reacting with said component to be detected and said interactive composition being bound to the fibers of said developing layer through a compound having a first reactive group for binding to said fibers and a second reactive group for binding to said interactive composition, and a portion of said reactive groups of said compound being bound to at least one of each other and groups in a binder or adjacent layers, thereby increasing the mechanical strength of the developing layer of fibrous structure and greatly enhancing adhesion to the adjacent layers.
Claim 3
Dependent Claim
23 words
The analytical element of claim 1 wherein said fibers are selected from the group consisting of natural macromolecular fibers and synthetic macromolecular fibers.
Claim 4
Dependent Claim
48 words
The analytical element of claim 1 wherein said first and second reactive groups are each selected from the group consisting of an epoxy group, an aldehyde group, an aziridyl group, a hydroxymethyl group, an isocyanate group, a thiol group, a carbamoyl group, a vinylsulfonyl group and precursors thereof.
Claim 5
Dependent Claim
25 words
The analytic element of claim 1 wherein a portion of said reactive groups of said compound are bound to said binder or said adjacent layers.
Claim 6
Dependent Claim
22 words
The analytical element of claim 1 wherein the compound is introduced into said developing layer by a low temperature plasma polymerization method.
Claim 7
Dependent Claim
20 words
The analytical element of claim 1 wherein the compound is introduced into said developing layer by a suspension polymerization method.
Claim 8
Dependent Claim
20 words
The analytical element of claim 1 wherein the compound is introduced into said developing layer by a radical polymerization method.
Claim 9
Dependent Claim
19 words
The analytical element of claim 1 wherein the compound is introduced into said developing layer by a photopolymerization method.
Claim 10
Dependent Claim
18 words
The analytical element of claim 1 wherein said developing layer has a thickness of 50 to 500 μm.
Claim 11
Dependent Claim
18 words
The analytical element of claim 9 wherein said developing layer has a thickness of 100 to 350 μm.
Claim 12
Dependent Claim
34 words
The analytical element of claim 1 wherein the compound having said first and second reactive groups is present in an amount of 0.1 to 100% by weight in said at least one developing layer.
Claim 13
Dependent Claim
35 words
The analytical element according to claim 11 wherein the compound having said first and second reactive groups is present in an amount of 0.5 to 85% by weight in said at least one developing layer.
Claim 14
Dependent Claim
37 words
The analytical element of claim 1 wherein said interactive composition comprises a material which reacts with said component to be detected in said liquid sample to produce a change in the electromagnetic characteristics of said liquid sample.
Claim 15
Dependent Claim
39 words
The analytical element of claim 13 wherein said interactive composition is a compound selected from the group consisting of a colorimetrically detectable compound; a phosphorimetrically detectable compound; a radiometrically detectable compound and a fluorimetrically detectable compound; and precursors thereof.
Claim 16
Dependent Claim
33 words
The interactive composition of claim 14 wherein said interactive composition is a member selected from the group consisting of an antigen, a hapten, an antibody, an antigen-antibody complex, an enzyme and precursors thereof.
Claim 17
Dependent Claim
20 words
The analytical element of claim 1 wherein the compound is introduced into said developing layer by a graft polymerization method.
Claim 18
Dependent Claim
17 words
The analytical element of claim 16 wherein the graft polymerization method is a radiation graft polymerization method.
Claim 19
Dependent Claim
25 words
The analytical element of claim 17 wherein the radiation graft polymerization method is a simultaneous irradiation graft polymerization method or a pre-irradiation graft polymerization method.
Claim 20
Dependent Claim
158 words
The analytical element of claim 1 wherein the compound having said first and second reactive groups is a copolymer of a first monomer having said first and second reactive groups with at least one second monomer selected from the group consisting of: ##STR2## wherein each of R 1 and R 2 , which can be the same or different, represents a non-interfering substituent and R 3 is selected from the group consisting of a hydrogen atom, a halogen atom, and a substituted or unsubstituted amino-free aliphatic or aromatic group having 1 to 10 carbon atoms; CHR.sup.6 ═CR.sup.4 --COOR.sup.5 (II) wherein R 6 has the same meaning as R 1 in the formula (I), R 4 is a hydrogen atom or a methyl group and R 5 represents an aryl, an alkyl, an alkaryl or an aralkyl group, each having 1 to 10 carbon atoms; (III) polymerizable unsaturated nitrile monomers; and (IV) interparticle crosslinking monomers having two addition-polymerizable groups.
Claim 21
Dependent Claim
73 words
The analytical element of claim 19 wherein the copolymer comprises 0.1 to 30% by weight of said first monomer, and as said second monomer 0 to 99.5% by weight of a monomer having the formula (II), 0 to 99.5% by weight of a monomer having the formula (II), 0 to 99.5% by weight of a monomer having the formula (III) and 0 to 10% by weight of a monomer having the formula (IV).
Claim 22
Dependent Claim
33 words
The analytical element of claim 19 wherein the copolymer having said first and second monomers is present in an amount of 0.2 to 200% by weight in said at least one developing layer.
Claim 23
Dependent Claim
44 words
The analytic element of claim 19 wherein each of R 1 and R 2 are selected from the group consisting of a hydrogen atom, a halogen atom, and a substituted or unsubstituted amino free alkyl or aryl group having 1 to 10 carbon atoms.
Claim 24
Dependent Claim
31 words
The analytical element of claim 22 wherein the second monomer is selected from the group consisting of styrene, vinyltoluene, vinylbenzyl chloride, t-butylstyrene, acrylonitrile, methacrylonitrile, divinylbenzene, N-n-methylene-bis(acrylamide), ethylene diacrylate and ethylene dimethacrylate.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-11-04 | 1989-05-06 | 1989-11-05 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-11-04 | 1993-05-06 | 1993-11-05 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-11-04 | 1997-05-06 | 1997-11-05 | $7700.00 | Window Closed / Lapsed |