Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof

Claim 1

A compound according to the formula: ##STR7## wherein R=lower alkyl, cycloalkyl, cycloalkyl(lower)alkyl, benzyl, or benzyl substituted by halogen, loweralkyl, loweralkoxy, or lower alkyl substituted by hydroxy, lower alkoxy, carbamoyl, N-loweralkylcarbamoyl, N,N-diloweralkylcarbamoyl and sulfamoyl; X,X 1 =hydrogen and halogen; R 1 =hydrogen, loweralkyl, unsaturated loweralkyl, loweralkoxyloweralkyl, or collectively with R 2 is an alkylene chain forming an azetidine, pyrrolidine, piperidine, or hexahydroazepine ring, or collectively with R 3 is a bond or an alkylene chain forming an azetidine, pyrrolidine, piperidine or a hexahydroazepine ring, or collectively with R 5 may produce a piperazine or a hexahydro-1,4-diazepine ring system; R 2 =hydrogen, loweralkyl or collectively with R 3 is a bond or an alkylene chain to form a saturated carbocyclic ring of from 4 to 8 ring carbon atoms. R 3 ,R 4 =hydrogen, loweralkyl or collectively is an alkylene chain forming a saturated carbocyclic ring of from 4 to 6 ring carbon atoms; R 5 ,R 6 =unsaturated loweralkyl, C 1 -C 12 straight or branched chain alkyl, C 3 -C 6 cycloalkyl, cycloalkyl(lower)alkyl, or when taken together form a saturated heterocyclic ring of from 4 to 8 ring members which may be substituted by one or more methyl groups or optionally contains a --O--, or ##STR8## linkage wherein p is the integer 0, 1 or 2; R 6 =loweralkyl substituted by phenyl which may be substituted by up to 3 substituents selected from hydroxy or methoxy groups; n=0, 1, 2; and the pharmaceutically acceptable salts thereof; with the proviso that: (a) when any of R 1 , R 5 or R 6 is unsaturated loweralkyl, the unsaturation cannot be alpha to the nitrogen atom.