Patent US4544640A successfully refreshed from Google Patents.
US4544640A
Expired / Lapsed
US
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Anti immune complex antibody for determining SLE, rheumatoid arthritis or tetanus
Assignee: Fujirebio Inc
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Filing: 1983-04-07
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Granted: 1985-10-01
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Expires: 2003-04-07
Abstract
Abstract An antibody is obtained by using as an antigen a complex of an antigen and the F(ab')2 fragment of the human antibody of this antigen or an aggregate of the F(ab')2 fragment of human immunoglobulin. This antibody reacts with an immune complex in a blood serum of a patient of systemic lupus erythematosus and with an immune complex in a blood serum of a patient of rheumatoid arthritis, and it does not react with an aggregated IgG. The amount of immune complex in a blood serum is easily and exactly determined by using this antibody.
Inventors
- 👤 Kazunori Soma
- 👤 Yasushi Kasahara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 13:20
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/563; G01N33/564; G01N2800/00; G01N2800/10; G01N2800/101; G01N2800/104; Y; Y10; Y10S; Y10S435/00; Y10S435/961; Y10S530/00; Y10S530/806; Y10S530/866; Y10S530/868
Claims Analysis
Total Claims: 23
Claim 1
Independent Claim
51 words
An anti-immune complex antibody, which is a glycoprotein having a molecular weight of from 150,000 to 180,000, as determined by gel filtration, reacts with an immune complex in a blood serum of a human patient having systemic lupus erythematosus, rheumatoid arthritis or tetanus, and which does not react with aggregated IgG.
Claim 2
Dependent Claim
51 words
An anti-immune complex antibody, which is a glycoprotein having a molecular weight of from 150,000 to 180,000, as determined by gel filtration, reacts with an immune complex in a blood serum of a human patient having systemic lupus erythematosus, rheumatoid arthritis or tetanus, and which does not react with aggregated IgG.
Claim 3
Dependent Claim
16 words
An anti-immune complex antibody as claimed in claim 1, in the form of a monoclonal antibody.
Claim 4
Dependent Claim
41 words
An anti-immune complex antibody as claimed in claim 1, which is the antibody to a complex of an antigen and the F(ab') 2 fragment of the human antibody to said antigen, and derived from a warm-blooded animal other than a human.
Claim 5
Dependent Claim
16 words
An anti-immune complex antibody, as claimed in claim 3, in the form of a monoclonal antibody.
Claim 6
Dependent Claim
14 words
An anti-immune complex antibody, as claimed in claim 3, wherein said antigen is water-soluble.
Claim 7
Dependent Claim
34 words
An anti-immune complex antibody as claimed in claim 1, which is the antibody to an aggregate of the F(ab') 2 fragment of human immunoglobulin, and derived from a warm-blooded animal other than a human.
Claim 8
Dependent Claim
16 words
An anti-immune complex antibody, as claimed in claim 6, in the form of a monoclonal antibody.
Claim 9
Dependent Claim
14 words
An anti-immune complex antibody, as claimed in claim 6, wherein said antigen is water-soluble.
Claim 10
Dependent Claim
15 words
An anti-immune complex antibody, as claimed in claim 6, wherein said human immunoglobulin is IgG.
Claim 11
Dependent Claim
51 words
A method of producing the anti-immune complex antibody of claim 1, which comprises producing a complex of an antigen and a F(ab') 2 fragment of the human antibody of this antigen, producing an antibody by using said complex as an antigen, and recovering said last-mentioned antibody as said anti-immune complex antibody.
Claim 12
Dependent Claim
36 words
A method of producing an anti-immune complex antibody as claimed in claim 10, wherein said complex is produced by contacting said antigen and said F(ab') 2 fragment of the human antibody of this antigen in solution.
Claim 13
Dependent Claim
33 words
A method of producing an anti-immune complex antibody as claimed in claim 11, wherein said antibody is derived from a warm-blooded animal other than a human by using said complex as an antigen.
Claim 14
Dependent Claim
20 words
A method of producing an anti-immune complex antibody as claimed in claim 12, wherein said antibody is produced in vitro.
Claim 15
Dependent Claim
20 words
A method of producing an anti-immune complex antibody as claimed in claim 12, wherein said antibody is produced in vivo.
Claim 16
Dependent Claim
29 words
A method of producing an anti-immune complex antibody as claimed in claim 12, wherein said warm-blooded animal is selected from the group consisting of rabbits, guinea pigs, and chickens.
Claim 17
Dependent Claim
35 words
A method of producing the anti-immune complex antibody of claim 1, which comprises producing said antibody by using an aggregate of the F(ab') 2 fragment of human immunoglobulin as an antigen, and recovering said antibody.
Claim 18
Dependent Claim
33 words
A method of producing an anti-immune complex antibody as claimed in claim 16, wherein said antibody is derived from a warm-blooded animal other than a human by using said complex as an antigen.
Claim 19
Dependent Claim
20 words
A method of producing an anti-immune complex antibody as claimed in claim 17, wherein said antibody is produced in vitro.
Claim 20
Dependent Claim
20 words
A method of producing an anti-immune complex antibody as claimed in claim 17, wherein said antibody is produced in vivo.
Claim 21
Dependent Claim
29 words
A method of producing an anti-immune complex antibody as claim in claim 17, wherein said warm-blooded animal is selected from the group consisting of rabbits, guinea pigs, and chickens.
Claim 22
Dependent Claim
19 words
A method of producing an anti-immune complex antibody as claimed in claim 16, wherein said human immunoglobulin is IgG.
Claim 23
Dependent Claim
45 words
A method of determining an immune complex in the blood serum of a patient with systemic lupus erythematosus, chronic articular rheumatism, or tetanus toxoid, comprising contacting the respective antibody of claim 1 with said blood serum to thereby react the immune complex with said antibody.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-30 | 1989-04-01 | 1989-10-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-30 | 1993-04-01 | 1993-10-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-30 | 1997-04-01 | 1997-10-01 | $7700.00 | Window Closed / Lapsed |