US4540410A
Expired / Lapsed
US
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Lyophilized compositions, preparation and use thereof
Assignee: Applied Research Systems ARS Holding NV
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Filing: 1982-11-16
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Granted: 1985-09-10
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Expires: 2002-11-16
Abstract
Abstract A syringe containing a lyophilized mixture of an absorbable gelatin powder and aminocaproic acid is prepared by mixing the gelatin powder, aminocaproic acid and water to form a slurry, introducing an aliquot of the slurry into a syringe and freeze-drying the slurry in the syringe.
Inventors
- 👤 Grace Wood
- 👤 Benjamin R. Duce
- 👤 Russell W. Pelham
- 👤 James Woiszwillo
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 16:23
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K38/00; A61K38/16; A61K38/17; A61K38/39
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
14 words
A syringe containing a lyophilized mixture of an absorbable gelatin powder and aminocaproic acid.
Claim 2
Dependent Claim
14 words
A syringe containing a lyophilized mixture of an absorbable gelatin powder and aminocaproic acid.
Claim 3
Dependent Claim
21 words
The syringe of claim 1 in which said powder is about 20-90% of the mixture of said powder and aminocaproic acid.
Claim 4
Dependent Claim
11 words
The syringe of claim 2 wherein said powder is about 40-60%.
Claim 5
Dependent Claim
11 words
The syringe of claim 3 wherein said powder is about 50%.
Claim 6
Dependent Claim
13 words
The syringe of claim 1 containing about 0.2-0.3 grams of said lyophilized mixture.
Claim 7
Independent Claim
48 words
A method of preparing a syringe containing a lyophilized mixture of an absorbable gelatin powder and aminocaproic acid which comprises admixing absorbable gelatin powder, aminocaproic acid and water to form a slurry, introducing an aliquot of the slurry into a syringe and lyophilizing the slurry in the syringe.
Claim 8
Independent Claim
48 words
A method of preparing a syringe containing a lyophilized mixture of an absorbable gelatin powder and aminocaproic acid which comprises admixing absorbable gelatin powder, aminocaproic acid and water to form a slurry, introducing an aliquot of the slurry into a syringe and lyophilizing the slurry in the syringe.
Claim 9
Dependent Claim
21 words
The method of claim 6 wherein the absorbable powder is about 20-90% of the mixture of the powder and aminocaproic acid.
Claim 10
Dependent Claim
29 words
The method of claim 7 wherein the powder is about 40-60% and the amount of water is about 1-10 parts per part of mixture of powder and aminocaproic acid.
Claim 11
Dependent Claim
30 words
The method of claim 8 wherein the powder is about 50% and in which the water is about 2-5 parts per part of the mixture of powder and aminocaproic acid.
Claim 12
Dependent Claim
25 words
The method of claim 6 wherein said aliquot is an amount of the slurry sufficient to yield about 0.3-0.5 grams of the resulting lyophilized mixture.
Claim 13
Dependent Claim
22 words
The method of claim 6 wherein said lyophilizing comprises freezing said slurry in the syringe and thereafter drawing off water under vacuum.
Claim 14
Dependent Claim
30 words
The method of claim 11 wherein the slurry in the syringe is lyophilized at a temperature below about at least -10° C. and at a vacuum of about 10-50 microns.
Claim 15
Dependent Claim
20 words
The method of claim 12 wherein the lyophilizing temperature is about -20° C. and the vacuum is about 50 microns.
Claim 16
Dependent Claim
65 words
The method of claim 13 wherein the powder is about 50% of the mixture of powder and aminocaproic acid, the water is about 2-5 parts per part of the mixture of powder and aminocaproic acid, the aminocaproic acid is employed in the form of an aqueous solution containing a preservative, and the aliquot is an amount sufficient to yield about 0.3-0.5 grams of lyophilized product.
Claim 17
Dependent Claim
66 words
A method of preparing a composition for repairing depressed cutaneous scars comprising plasma, absorbable gelatin powder and aminocaproic acid which comprises introducing plasma of the patient to be treated into a syringe, interlocking the plasma syringe with the syringe of claim 1, and forcing the contents of one syringe into the other syringe a plurality of times until the desired degree of admixing has been obtained.
Claim 18
Dependent Claim
39 words
The method of claim 15 in which the plasma syringe contains about 0.3-0.5 cc plasma and about 0.3-0.5 cc of aqueous NaCl and the syringe of claim 1 contains about 40-100 mg powder and about 25-150 mg aminocaproic acid.
Claim 19
Dependent Claim
24 words
The method of claim 16 in which the syringe of claim 1 contains about 60-100 mg of each of said powder and aminocaproic acid.
Claim 20
Dependent Claim
21 words
A syringe containing a lyophilized mixture of an absorbable gelatin powder and aminocaproic acid produced by the process of claim 6.
Claim 21
Dependent Claim
21 words
The syringe of claim 18 in which said powder is about 20-90% of said mixture of said powder and aminocaproic acid.
Claim 22
Dependent Claim
17 words
The syringe of claim 19 in which the amount of said lyophilized mixture is about 0.2-0.3 gram.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-09-09 | 1989-03-11 | 1989-09-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-09-09 | 1993-03-11 | 1993-09-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-09-09 | 1997-03-11 | 1997-09-10 | $7700.00 | Window Closed / Lapsed |