Patent US2972678A successfully refreshed from Google Patents.
US4061731A
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Compositions containing collagen and methods of use for repairing depressed cutaneous scars
Assignee: Mentor Worldwide LLC
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Filing: 1977-01-31
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Granted: 1977-12-06
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Expires: 1997-01-31
Abstract
Abstract Compositions useful for the repair of depressed cutaneous scars comprising at least one fibrin stabilizer and plasma, if desired, wherein said fibrin stabilizer is present in an amount effective to maintain fibrin within a cavity preferably formed under said scar. One fibrin stabilizer used is finely-divided collagen. The compositions promote the build-up of new collagen within the aforementioned cavity.
Inventors
- 👤 Sheldon K. Gottlieb
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 21:14
CPC Classifications
A; A61; A61L; A61L15/00; A61L15/16; A61L15/42; A61L15/64; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K31/197; A61K35/00; A61K35/12; A61K35/14; A61K35/16; A61K38/00; A61K38/16; A61K38/17; A61K38/39; A61L15/44; A61L2300/00; A61L2300/40; A61L2300/412
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
59 words
A composition useful for the repair of depressed cutaneous scars comprising finely-divided collagen and plasma, said collagen being present in an amount effective to maintain fibrin within a cavity formed under said scar and thereby cause the build-up of new collagen within said cavity and said plasma being present in an amount to provide sufficient fibrin within said cavity.
Claim 2
Dependent Claim
59 words
A composition useful for the repair of depressed cutaneous scars comprising finely-divided collagen and plasma, said collagen being present in an amount effective to maintain fibrin within a cavity formed under said scar and thereby cause the build-up of new collagen within said cavity and said plasma being present in an amount to provide sufficient fibrin within said cavity.
Claim 3
Dependent Claim
16 words
The composition of claim 1 wherein said composition contains up to 0.5 cc of human plasma.
Claim 4
Dependent Claim
58 words
The composition of claim 2 further comprising at least one additional fibrin stabilizer, said fibrin stabilizer being selected from the group consisting of: (1) pulverized absorbable gelatin sponge, (2) aminocaproic acid, (3) a compound of the formula 4NH 2 CH 2 (CH 2 ) 4 COOH.sup.. CaX 2 wherein X is chloride or bromide, and (4) mixtures thereof.
Claim 5
Dependent Claim
26 words
The composition of claim 3 containing from about 5 to 50 mg. of said pulverized absorbable gelatin sponge for each 0.3 to 0.5 cc of plasma
Claim 6
Dependent Claim
23 words
The composition of claim 3 containing from about 12.5 to 75 mg. of aminocaproic acid for each 0.3 to 0.5 cc. of plasma.
Claim 7
Dependent Claim
48 words
The composition of claim 3 containing a mixture of said pulverized absorbable gelatin sponge and aminocaproic acid wherein said mixture consists of from 20 to 50 mg. of pulverized absorbable gelatin sponge and from 12.5 to 75 mg. of aminocaproic acid for up to 0.5 cc of plasma.
Claim 8
Dependent Claim
23 words
In a method for repairing a depressed cutaneous scar comprising the step of introducing the composition of claim 1 intradermally beneath said scar.
Claim 9
Dependent Claim
18 words
The method of claim 7 comprising initially transecting the fibrous tissue beneath said scar thereby forming a cavity.
Claim 10
Dependent Claim
34 words
The method of claim 8 comprising introducing a sufficient amount of said composition to stimulate the formation of new tissue thereby resulting in the permanent elevation of the depression to the normal skin level.
Claim 11
Dependent Claim
95 words
A composition useful for the repair of depressed cutaneous scars comprising finely-divided collagen in combination with: a. pulverized absorbable sponge, or b. a member selected from the group consisting of aminocaproic acid, compounds of the formula: 4NH 2 CH 2 (CH 2 ) 4 COOH.sup.. CaX 2 and mixtures thereof, or c. mixtures of (a) and (b), wherein the total amount of collagen and components (a) and (b) are present in an amount sufficient to maintain fibrin within a cavity formed under said scar and thereby cause the build-up of new collagen within said cavity.
Claim 12
Dependent Claim
95 words
A composition useful for the repair of depressed cutaneous scars comprising finely-divided collagen in combination with: a. pulverized absorbable sponge, or b. a member selected from the group consisting of aminocaproic acid, compounds of the formula: 4NH 2 CH 2 (CH 2 ) 4 COOH.sup.. CaX 2 and mixtures thereof, or c. mixtures of (a) and (b), wherein the total amount of collagen and components (a) and (b) are present in an amount sufficient to maintain fibrin within a cavity formed under said scar and thereby cause the build-up of new collagen within said cavity.
Claim 13
Dependent Claim
10 words
The composition of claim 10 wherein (b) is aminocaproic acid.
Claim 14
Dependent Claim
31 words
The composition of claim 11 containing from about 20 to 50 mg. of finely-divided fibrous collagen, 0 to 50 mg. of pulverized absorbable sponge, and 0 to 75 mg. of (b).
Claim 15
Dependent Claim
17 words
The composition of claim 12 wherein (b) is present in an amount between 12.5 and 75 mg.
Claim 16
Dependent Claim
23 words
In a method for repairing a depressed cutaneous scar comprising the step of introducing the composition of claim 10 intradermally beneath said scar.
Claim 17
Dependent Claim
18 words
The method of claim 14 comprising initially transecting the fibrous tissue beneath said scar thereby forming a cavity.
Claim 18
Dependent Claim
34 words
The method of claim 15 comprising introducing a sufficient amount of said composition to stimulate the formation of new tissue thereby resulting in the permanent elevation of the depression to the normal skin level.
Claim 19
Dependent Claim
15 words
The method of claim 16 wherein said composition further comprises a pharmaceutically acceptable inert carrier.
Claim 20
Dependent Claim
11 words
The method of claim 17 wherein said inert carrier is water.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-12-05 | 1981-06-06 | 1981-12-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-12-05 | 1985-06-06 | 1985-12-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-12-05 | 1989-06-06 | 1989-12-06 | $7700.00 | Window Closed / Lapsed |