US4533502A
Expired / Lapsed
US
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Platinum (II) compounds and their preparation
Assignee: Individual
•
Filing: 1983-02-22
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Granted: 1985-08-06
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Expires: 2003-02-22
Abstract
Abstract This invention relates in one aspect to various methods for preparing platinum (II) complexes and in another aspect to certain novel ligand platinum complexes, i.e.: ##STR1## where X is a monodentate ligand (X 2 ) or a bidentate ligand Y, and where L and L' are ligands bonded through amine nitrogen (including pyridine type nitrogen), or DMF, and where preferably L≠L'. Various novel platinum compounds within the above reaction series are also claimed.
Inventors
- 👤 Fernande D. Rochon
- 👤 Pi-Chang Kong
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 23:28
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
113 words
A method for the preparation of an oligomer having the emperical formula [PtLI 2 ] x where x is a lower integer, 2 or higher and each L is the same and is ammine, a primary or secondary mono amine or a pyridine-type amine, coordinated to the Pt through the amine nitrogen, or dimethylformamide coordinated through the oxygen atom to the platinum which method comprises reacting a compound corresponding to the formula cis-[PtL.sub.2 I.sub.2 ] where L is as defined above in the presence of a molar excess of a platinum non-reactive aqueous acid in admixture with a water miscible inert solvent for said [PtL 2 I 2 ], thereby forming said oligomer.
Claim 2
Independent Claim
113 words
A method for the preparation of an oligomer having the emperical formula [PtLI 2 ] x where x is a lower integer, 2 or higher and each L is the same and is ammine, a primary or secondary mono amine or a pyridine-type amine, coordinated to the Pt through the amine nitrogen, or dimethylformamide coordinated through the oxygen atom to the platinum which method comprises reacting a compound corresponding to the formula cis-[PtL.sub.2 I.sub.2 ] where L is as defined above in the presence of a molar excess of a platinum non-reactive aqueous acid in admixture with a water miscible inert solvent for said [PtL 2 I 2 ], thereby forming said oligomer.
Claim 3
Dependent Claim
18 words
The method as in claim 1 where L is a primary or secondary monoamine or a pyridine-type amine.
Claim 4
Independent Claim
15 words
The method as in claims 1 or 2 where the solvent is a lower alkanol.
Claim 5
Dependent Claim
12 words
The method as in claim 3 where the acid is perchloric acid.
Claim 6
Dependent Claim
37 words
An oligomer corresponding to the emperical formula [PtLI.sub.2 ].sub.x where x is a lower integer, 2 or higher, and each L is the same and is ammine, a primary or secondary mono amine or a pyridine-type amine.
Claim 7
Dependent Claim
37 words
An oligomer corresponding to the emperical formula [PtLI.sub.2 ].sub.x where x is a lower integer, 2 or higher, and each L is the same and is ammine, a primary or secondary mono amine or a pyridine-type amine.
Claim 8
Dependent Claim
18 words
The oligomer as in claim 5 where L is a primary or secondary monoamine or a pyridine-type amine.
Claim 9
Independent Claim
81 words
A method for the preparation of a platinous complex corresponding to the formula cis-[PtLL'I.sub.2 ] where L≠L' and where L and L' is ammine, a primary or secondary monoamine, a pyridine-type amine, or N,N-dimethylformamide which comprises reacting an oligomer corresponding to the formula [PtLI.sub.2 ].sub.x where x is a lower integer, 2 or higher, with an amine or N,N-dimethylformamide (L'), in a reaction medium in which the product is substantially insoluble comprising, essentially in water, to form said cis-[PtLL'I 2 ].
Claim 10
Independent Claim
81 words
A method for the preparation of a platinous complex corresponding to the formula cis-[PtLL'I.sub.2 ] where L≠L' and where L and L' is ammine, a primary or secondary monoamine, a pyridine-type amine, or N,N-dimethylformamide which comprises reacting an oligomer corresponding to the formula [PtLI.sub.2 ].sub.x where x is a lower integer, 2 or higher, with an amine or N,N-dimethylformamide (L'), in a reaction medium in which the product is substantially insoluble comprising, essentially in water, to form said cis-[PtLL'I 2 ].
Claim 11
Dependent Claim
19 words
The method as in claim 7 where L is a primary or secondary monoamine or a pyridine type amine.
Claim 12
Independent Claim
14 words
The method as in claims 7 or 8 where the reaction medium is water.
Claim 13
Dependent Claim
22 words
An oligomer as in claim 5 wherein each L is the same and is ammine, or a primary or secondary mono amine.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-08-05 | 1989-02-04 | 1989-08-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-08-05 | 1993-02-04 | 1993-08-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-08-05 | 1997-02-04 | 1997-08-06 | $7700.00 | Window Closed / Lapsed |