1-Heteroaryl-4-(2,5-pyrrolidinedion-1-yl)alkyl)piperazine derivatives

Claim 1

A compound having Formula I ##STR39## wherein R 1 is C 1-4 alkyl, trifluoromethyl, Z-substituted phenyl with Z being hydrogen or halogen or R 1 can be taken together with R 2 as a C 4-5 alkylene bridge incorporating a fused Z-substituted phenyl ring system, Z being hydrogen or halogen or R 1 can be taken together with R 3 to form a fused cyclohexenyl ring or an X 1 -X 4 tetra-substituted phenyl ring with X 1 -X 4 being independently selected from hydrogen, halogen or nitro; R 2 is C 1-4 alkyl, Z-substituted phenyl with Z as defined above, or absent when R 1 and R 3 form a fused phenyl ring system, or taken together with R 1 to form an alkylene bridge as defined above; R 3 is H 2 or can be taken together with R 1 to form a fused phenyl ring as defined above; B is an R 4 ,R 5 -disubstituted heterocyclic ring system chosen from the group consisting of benzoisothiazole, pyridine, and pyrimidine, with R 4 and R 5 being independently selected from C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, cyano, halogen, or hydrogen; and n is 2-4; or a pharmaceutically acceptable acid addition salt thereof.