US4524075A
Expired / Lapsed
US
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Pharmaceutical formulations containing pseudomonic acid
Assignee: Beecham Group PLC
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Filing: 1983-05-26
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Granted: 1985-06-18
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Expires: 2003-05-26
Abstract
Abstract Topical formulations comprise pseudomonic acid or a salt or ester thereof and a polyethylene glycol or polyethylene glycol analogue or derivative.
Inventors
- 👤 Joshua Oduro-Yeboah
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 19:40
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/335; A61K31/35; A61K47/00; A61K47/06; A61K47/08; A61K47/10; A61K47/22; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 21
Claim 1
Independent Claim
60 words
A highly stable pharmaceutical composition in topical application form which comprises an antibacterially effective amount of pseudomonic acid, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof and a stabilizing amount of at least 1% by weight of a poly(alkylene)glycol, a poly(alkoxy substituted alkylene)glycol, a pharmaceutically acceptable ether thereof, a pharmaceutically acceptable ester thereof or a mixture thereof.
Claim 2
Dependent Claim
60 words
A highly stable pharmaceutical composition in topical application form which comprises an antibacterially effective amount of pseudomonic acid, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable ester thereof and a stabilizing amount of at least 1% by weight of a poly(alkylene)glycol, a poly(alkoxy substituted alkylene)glycol, a pharmaceutically acceptable ether thereof, a pharmaceutically acceptable ester thereof or a mixture thereof.
Claim 3
Dependent Claim
22 words
A formulation according to claim 1 comprising from 0.01 to 50% by weight of pseudomonic acid or a salt or ester thereof.
Claim 4
Dependent Claim
22 words
A formulation according to claim 2 comprising from 0.1 to 25% by weight of pseudomonic acid or a salt or ester thereof.
Claim 5
Dependent Claim
22 words
A formulation according to claim 3 comprising from 0.5 to 10% by weight of pseudomonic acid or a salt or ester thereof.
Claim 6
Dependent Claim
20 words
A formulation according to claim 4 comprising about 2% by weight of pseudomonic acid or a salt or ester thereof.
Claim 7
Dependent Claim
20 words
A formulation according to claim 1 wherein pseudomonic acid or a salt or ester thereof is the sole therapeutic agent.
Claim 8
Dependent Claim
20 words
A formulation according to claim 1 wherein the pseudomonic acid, salt or ester is in the form of the acid.
Claim 9
Dependent Claim
22 words
A formulation according to claim 1 wherein the pseudomonic acid, salt or ester is in the form of an alkali metal salt.
Claim 10
Dependent Claim
22 words
A formulation according to claim 8 in the form of an alkali metal salt wherein the alkali metal salt is sodium pseudomonate.
Claim 11
Dependent Claim
27 words
A formulation according to claim 1 wherein the pseudomonic acid, salt or ester is in the form of an alkyl ester of 1 to 4 carbon atoms.
Claim 12
Dependent Claim
15 words
A formulation according to claim 10 wherein the alkyl ester is methyl or ethyl pseudomonate.
Claim 13
Dependent Claim
12 words
A formulation according to claim 1 wherein the glycol is polyethylene glycol.
Claim 14
Dependent Claim
48 words
A formulation according to claim 1 which contains at least 1% by weight of polyethylene glycol or a mixture of polyethylene glycols and from 0 to 25% by weight of a poly(alkoxy substituted alkylene)glycol, a pharmaceutically acceptable ether thereof, a pharmaceutically acceptable ester thereof or a mixture thereof.
Claim 15
Dependent Claim
15 words
A formulation according to claim 13 which contains polyethylene glycol 400 and polyethylene glycol 4000.
Claim 16
Dependent Claim
15 words
A formulation according to claim 13 which contains polyethylene glycol 400 and glycofurol or cetomacrogol.
Claim 17
Dependent Claim
21 words
A formulation according to claim 13 which contains from 0.5 to 10% of pseudomonic acid or a salt or ester thereof.
Claim 18
Dependent Claim
21 words
A formulation according to claim 14 which contains from 0.5 to 10% of pseudomonic acid or a salt or ester thereof.
Claim 19
Dependent Claim
19 words
A formulation according to claim 15 which contains from 0.5 to 10% of pseudomonic acid or a salt thereof.
Claim 20
Dependent Claim
12 words
A formulation according to claim 1 in lotion, cream or ointment form.
Claim 21
Dependent Claim
18 words
A formulation according to claim 1 in the form of drops for application to the ears or eyes.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1988-06-17 | 1988-12-17 | 1989-06-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1992-06-17 | 1992-12-17 | 1993-06-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1996-06-17 | 1996-12-17 | 1997-06-18 | $7700.00 | Window Closed / Lapsed |